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Gene: IBTK |
Gene summary for IBTK |
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Gene information | Species | Human | Gene symbol | IBTK | Gene ID | 25998 |
Gene name | inhibitor of Bruton tyrosine kinase | |
Gene Alias | BTBD26 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | B7ZLE0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25998 | IBTK | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.10e-09 | -5.34e-01 | 0.0155 |
25998 | IBTK | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.58e-04 | -3.52e-01 | 0.0674 |
25998 | IBTK | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.18e-02 | -5.09e-01 | 0.0588 |
25998 | IBTK | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.96e-08 | -4.65e-01 | 0.3005 |
25998 | IBTK | A015-C-203 | Human | Colorectum | FAP | 1.56e-19 | -3.51e-01 | -0.1294 |
25998 | IBTK | A015-C-204 | Human | Colorectum | FAP | 1.52e-02 | -2.41e-01 | -0.0228 |
25998 | IBTK | A014-C-040 | Human | Colorectum | FAP | 1.97e-02 | -3.81e-01 | -0.1184 |
25998 | IBTK | A002-C-201 | Human | Colorectum | FAP | 4.14e-11 | -4.04e-01 | 0.0324 |
25998 | IBTK | A001-C-119 | Human | Colorectum | FAP | 3.49e-02 | -3.40e-01 | -0.1557 |
25998 | IBTK | A001-C-108 | Human | Colorectum | FAP | 1.12e-10 | -1.22e-01 | -0.0272 |
25998 | IBTK | A002-C-205 | Human | Colorectum | FAP | 2.00e-15 | -3.74e-01 | -0.1236 |
25998 | IBTK | A015-C-006 | Human | Colorectum | FAP | 4.33e-09 | -2.94e-01 | -0.0994 |
25998 | IBTK | A015-C-106 | Human | Colorectum | FAP | 6.03e-07 | -2.47e-01 | -0.0511 |
25998 | IBTK | A002-C-114 | Human | Colorectum | FAP | 2.11e-12 | -3.53e-01 | -0.1561 |
25998 | IBTK | A015-C-104 | Human | Colorectum | FAP | 1.09e-20 | -3.23e-01 | -0.1899 |
25998 | IBTK | A001-C-014 | Human | Colorectum | FAP | 1.65e-06 | -1.50e-01 | 0.0135 |
25998 | IBTK | A002-C-016 | Human | Colorectum | FAP | 1.96e-10 | -2.51e-01 | 0.0521 |
25998 | IBTK | A015-C-002 | Human | Colorectum | FAP | 5.44e-08 | -2.85e-01 | -0.0763 |
25998 | IBTK | A001-C-203 | Human | Colorectum | FAP | 3.30e-04 | -2.23e-01 | -0.0481 |
25998 | IBTK | A002-C-116 | Human | Colorectum | FAP | 4.54e-18 | -2.21e-01 | -0.0452 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165133 | Thyroid | ATC | maintenance of location in cell | 105/6293 | 214/18723 | 1.92e-06 | 2.31e-05 | 105 |
GO:006109913 | Thyroid | ATC | negative regulation of protein tyrosine kinase activity | 20/6293 | 31/18723 | 4.20e-04 | 2.51e-03 | 20 |
GO:005073211 | Thyroid | ATC | negative regulation of peptidyl-tyrosine phosphorylation | 32/6293 | 59/18723 | 8.74e-04 | 4.72e-03 | 32 |
GO:006109712 | Thyroid | ATC | regulation of protein tyrosine kinase activity | 45/6293 | 90/18723 | 9.39e-04 | 5.04e-03 | 45 |
GO:001821211 | Thyroid | ATC | peptidyl-tyrosine modification | 156/6293 | 378/18723 | 1.01e-03 | 5.36e-03 | 156 |
GO:00181086 | Thyroid | ATC | peptidyl-tyrosine phosphorylation | 153/6293 | 375/18723 | 1.96e-03 | 9.48e-03 | 153 |
GO:00507305 | Thyroid | ATC | regulation of peptidyl-tyrosine phosphorylation | 108/6293 | 264/18723 | 7.50e-03 | 2.93e-02 | 108 |
Page: 1 2 3 4 5 6 7 8 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IBTK | SNV | Missense_Mutation | novel | c.346G>T | p.Asp116Tyr | p.D116Y | Q9P2D0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IBTK | SNV | Missense_Mutation | rs757965458 | c.865N>A | p.Val289Ile | p.V289I | Q9P2D0 | protein_coding | tolerated(0.15) | possibly_damaging(0.906) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IBTK | SNV | Missense_Mutation | c.3443C>T | p.Ser1148Phe | p.S1148F | Q9P2D0 | protein_coding | deleterious(0.05) | possibly_damaging(0.526) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
IBTK | SNV | Missense_Mutation | c.3134N>T | p.Ser1045Phe | p.S1045F | Q9P2D0 | protein_coding | deleterious(0) | possibly_damaging(0.556) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IBTK | SNV | Missense_Mutation | c.1406N>C | p.Arg469Thr | p.R469T | Q9P2D0 | protein_coding | tolerated(0.06) | benign(0.094) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
IBTK | SNV | Missense_Mutation | rs772636120 | c.2201N>A | p.Ser734Asn | p.S734N | Q9P2D0 | protein_coding | tolerated(0.14) | possibly_damaging(0.448) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
IBTK | SNV | Missense_Mutation | novel | c.604N>C | p.Gly202Arg | p.G202R | Q9P2D0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A5PV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
IBTK | SNV | Missense_Mutation | rs376596320 | c.467G>A | p.Gly156Asp | p.G156D | Q9P2D0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IBTK | SNV | Missense_Mutation | c.106T>G | p.Phe36Val | p.F36V | Q9P2D0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IBTK | SNV | Missense_Mutation | c.113N>G | p.Ser38Cys | p.S38C | Q9P2D0 | protein_coding | deleterious(0.02) | probably_damaging(0.949) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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