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Gene: HSBP1 |
Gene summary for HSBP1 |
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Gene information | Species | Human | Gene symbol | HSBP1 | Gene ID | 3281 |
Gene name | heat shock factor binding protein 1 | |
Gene Alias | NPC-A-13 | |
Cytomap | 16q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75506 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3281 | HSBP1 | CA_HPV_1 | Human | Cervix | CC | 3.49e-10 | -1.59e-01 | 0.0264 |
3281 | HSBP1 | CCI_1 | Human | Cervix | CC | 4.02e-10 | -6.80e-01 | 0.528 |
3281 | HSBP1 | CCI_3 | Human | Cervix | CC | 4.12e-10 | -6.23e-01 | 0.516 |
3281 | HSBP1 | CCII_1 | Human | Cervix | CC | 1.72e-16 | -6.55e-01 | 0.3249 |
3281 | HSBP1 | Tumor | Human | Cervix | CC | 1.56e-04 | 3.30e-01 | 0.1241 |
3281 | HSBP1 | sample3 | Human | Cervix | CC | 3.36e-07 | 3.04e-01 | 0.1387 |
3281 | HSBP1 | L1 | Human | Cervix | CC | 2.74e-04 | -3.45e-02 | 0.0802 |
3281 | HSBP1 | T3 | Human | Cervix | CC | 5.86e-08 | 3.39e-01 | 0.1389 |
3281 | HSBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.00e-09 | 2.22e-01 | 0.0155 |
3281 | HSBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.51e-18 | 5.79e-01 | -0.1808 |
3281 | HSBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.34e-15 | 5.32e-01 | -0.0811 |
3281 | HSBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.42e-05 | 2.43e-01 | -0.1088 |
3281 | HSBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.90e-25 | 5.86e-01 | -0.1954 |
3281 | HSBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.79e-10 | 9.25e-01 | -0.2602 |
3281 | HSBP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.17e-08 | 4.27e-01 | -0.1207 |
3281 | HSBP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.03e-09 | 3.44e-01 | -0.1526 |
3281 | HSBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.13e-15 | 4.85e-01 | -0.1464 |
3281 | HSBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.87e-10 | 3.16e-01 | -0.1001 |
3281 | HSBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.60e-26 | 6.92e-01 | -0.059 |
3281 | HSBP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-05 | 5.66e-01 | -0.1706 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00017061 | Prostate | Tumor | endoderm formation | 19/3246 | 54/18723 | 1.24e-03 | 7.82e-03 | 19 |
GO:007238411 | Prostate | Tumor | organelle transport along microtubule | 26/3246 | 85/18723 | 1.90e-03 | 1.11e-02 | 26 |
GO:00989301 | Prostate | Tumor | axonal transport | 20/3246 | 64/18723 | 4.62e-03 | 2.27e-02 | 20 |
GO:00359871 | Prostate | Tumor | endodermal cell differentiation | 15/3246 | 45/18723 | 6.94e-03 | 3.13e-02 | 15 |
GO:000940820 | Skin | AK | response to heat | 29/1910 | 110/18723 | 1.18e-06 | 3.73e-05 | 29 |
GO:00073699 | Skin | AK | gastrulation | 41/1910 | 185/18723 | 1.32e-06 | 4.13e-05 | 41 |
GO:003460524 | Skin | AK | cellular response to heat | 21/1910 | 69/18723 | 2.93e-06 | 7.82e-05 | 21 |
GO:00017045 | Skin | AK | formation of primary germ layer | 30/1910 | 121/18723 | 3.12e-06 | 8.17e-05 | 30 |
GO:005165618 | Skin | AK | establishment of organelle localization | 69/1910 | 390/18723 | 3.69e-06 | 9.11e-05 | 69 |
GO:003070519 | Skin | AK | cytoskeleton-dependent intracellular transport | 40/1910 | 195/18723 | 1.29e-05 | 2.58e-04 | 40 |
GO:00074927 | Skin | AK | endoderm development | 21/1910 | 77/18723 | 1.95e-05 | 3.64e-04 | 21 |
GO:00017065 | Skin | AK | endoderm formation | 16/1910 | 54/18723 | 6.27e-05 | 9.23e-04 | 16 |
GO:000926620 | Skin | AK | response to temperature stimulus | 34/1910 | 178/18723 | 2.38e-04 | 2.61e-03 | 34 |
GO:000808816 | Skin | AK | axo-dendritic transport | 17/1910 | 75/18723 | 1.22e-03 | 9.32e-03 | 17 |
GO:00359874 | Skin | AK | endodermal cell differentiation | 12/1910 | 45/18723 | 1.43e-03 | 1.05e-02 | 12 |
GO:00516464 | Skin | AK | mitochondrion localization | 12/1910 | 50/18723 | 3.74e-03 | 2.22e-02 | 12 |
GO:00030129 | Skin | AK | muscle system process | 64/1910 | 452/18723 | 4.32e-03 | 2.52e-02 | 64 |
GO:00516543 | Skin | AK | establishment of mitochondrion localization | 8/1910 | 29/18723 | 6.99e-03 | 3.63e-02 | 8 |
GO:00109708 | Skin | AK | transport along microtubule | 26/1910 | 155/18723 | 7.60e-03 | 3.86e-02 | 26 |
GO:005165624 | Skin | cSCC | establishment of organelle localization | 178/4864 | 390/18723 | 2.18e-17 | 2.32e-15 | 178 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSBP1 | SNV | Missense_Mutation | c.150N>C | p.Lys50Asn | p.K50N | O75506 | protein_coding | deleterious(0.01) | benign(0.394) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSBP1 | SNV | Missense_Mutation | c.90N>C | p.Met30Ile | p.M30I | O75506 | protein_coding | tolerated(0.05) | benign(0.069) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSBP1 | SNV | Missense_Mutation | rs780323241 | c.130C>T | p.Arg44Cys | p.R44C | O75506 | protein_coding | tolerated(0.09) | benign(0.178) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HSBP1 | SNV | Missense_Mutation | novel | c.218N>T | p.Thr73Met | p.T73M | O75506 | protein_coding | deleterious(0.03) | benign(0.387) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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