GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:004586122 | Liver | HCC | negative regulation of proteolysis | 186/7958 | 351/18723 | 4.19e-05 | 4.11e-04 | 186 |
GO:007084111 | Liver | HCC | inclusion body assembly | 20/7958 | 24/18723 | 4.92e-05 | 4.70e-04 | 20 |
GO:0098930 | Liver | HCC | axonal transport | 43/7958 | 64/18723 | 5.73e-05 | 5.31e-04 | 43 |
GO:00109702 | Liver | HCC | transport along microtubule | 90/7958 | 155/18723 | 6.49e-05 | 5.92e-04 | 90 |
GO:000042311 | Liver | HCC | mitophagy | 22/7958 | 28/18723 | 1.10e-04 | 9.41e-04 | 22 |
GO:000975521 | Liver | HCC | hormone-mediated signaling pathway | 106/7958 | 190/18723 | 1.45e-04 | 1.17e-03 | 106 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:003052121 | Liver | HCC | androgen receptor signaling pathway | 31/7958 | 44/18723 | 1.63e-04 | 1.30e-03 | 31 |
GO:0051646 | Liver | HCC | mitochondrion localization | 34/7958 | 50/18723 | 2.38e-04 | 1.79e-03 | 34 |
GO:0098732 | Liver | HCC | macromolecule deacylation | 67/7958 | 116/18723 | 6.46e-04 | 3.99e-03 | 67 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:0040029 | Liver | HCC | regulation of gene expression, epigenetic | 61/7958 | 105/18723 | 9.02e-04 | 5.31e-03 | 61 |
GO:1904923 | Liver | HCC | regulation of autophagy of mitochondrion in response to mitochondrial depolarization | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:00356011 | Liver | HCC | protein deacylation | 64/7958 | 112/18723 | 1.23e-03 | 6.83e-03 | 64 |
GO:00454441 | Liver | HCC | fat cell differentiation | 120/7958 | 229/18723 | 1.52e-03 | 8.05e-03 | 120 |
GO:003647312 | Liver | HCC | cell death in response to oxidative stress | 55/7958 | 95/18723 | 1.76e-03 | 9.12e-03 | 55 |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HDAC6 | MYOFIB | Colorectum | ADJ | OTUD6B-AS1,COL13A1,RNF170, etc. | 3.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | MYOFIB | Colorectum | FAP | OTUD6B-AS1,COL13A1,RNF170, etc. | 2.54e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
HDAC6 | BAS | Endometrium | ADJ | MINDY2,ZNF662,TAF1C, etc. | 6.21e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | iATC | Thyroid | Healthy | MRPL36,NSRP1,MVB12A, etc. | 6.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC6 | SNV | Missense_Mutation | novel | c.3579G>C | p.Gln1193His | p.Q1193H | Q9UBN7 | protein_coding | deleterious(0) | possibly_damaging(0.722) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
HDAC6 | SNV | Missense_Mutation | | c.2601N>A | p.Met867Ile | p.M867I | Q9UBN7 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HDAC6 | SNV | Missense_Mutation | rs782451640 | c.2609G>A | p.Arg870Gln | p.R870Q | Q9UBN7 | protein_coding | tolerated(0.48) | benign(0.033) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.1699N>T | p.Asp567Tyr | p.D567Y | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |
HDAC6 | SNV | Missense_Mutation | | c.379C>G | p.Arg127Gly | p.R127G | Q9UBN7 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
HDAC6 | SNV | Missense_Mutation | | c.2518N>C | p.Glu840Gln | p.E840Q | Q9UBN7 | protein_coding | deleterious(0.03) | benign(0.113) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.846N>T | p.Arg282Ser | p.R282S | Q9UBN7 | protein_coding | tolerated(0.77) | benign(0.038) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.208N>A | p.Gly70Arg | p.G70R | Q9UBN7 | protein_coding | deleterious(0.03) | benign(0.294) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
HDAC6 | SNV | Missense_Mutation | rs781974625 | c.3181N>A | p.Glu1061Lys | p.E1061K | Q9UBN7 | protein_coding | tolerated(0.35) | benign(0) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | rs782618133 | c.2021N>G | p.Tyr674Cys | p.Y674C | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-32i | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-28 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-9 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-14 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PRACINOSTAT | PRACINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-33p | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | BELINOSTAT | BELINOSTAT | 25937017 |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051807 | SCRIPTAID | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051792 | PANOBINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 249565599 | | |