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Gene: GRSF1 |
Gene summary for GRSF1 |
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Gene information | Species | Human | Gene symbol | GRSF1 | Gene ID | 2926 |
Gene name | G-rich RNA sequence binding factor 1 | |
Gene Alias | GRSF1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000957 | UniProtAcc | A0A024RD99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2926 | GRSF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.27e-09 | 4.76e-01 | -0.1954 |
2926 | GRSF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.67e-08 | 5.46e-01 | 0.294 |
2926 | GRSF1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.38e-03 | 4.12e-01 | 0.3859 |
2926 | GRSF1 | A002-C-010 | Human | Colorectum | FAP | 5.75e-03 | -1.00e-01 | 0.242 |
2926 | GRSF1 | A015-C-203 | Human | Colorectum | FAP | 1.03e-11 | -1.47e-01 | -0.1294 |
2926 | GRSF1 | A002-C-201 | Human | Colorectum | FAP | 2.98e-03 | -1.30e-01 | 0.0324 |
2926 | GRSF1 | A001-C-108 | Human | Colorectum | FAP | 9.91e-05 | -7.65e-02 | -0.0272 |
2926 | GRSF1 | A002-C-205 | Human | Colorectum | FAP | 7.21e-06 | -7.53e-02 | -0.1236 |
2926 | GRSF1 | A015-C-006 | Human | Colorectum | FAP | 9.05e-05 | -1.18e-01 | -0.0994 |
2926 | GRSF1 | A015-C-106 | Human | Colorectum | FAP | 4.19e-05 | -1.60e-01 | -0.0511 |
2926 | GRSF1 | A002-C-114 | Human | Colorectum | FAP | 1.44e-04 | -9.74e-02 | -0.1561 |
2926 | GRSF1 | A015-C-104 | Human | Colorectum | FAP | 1.81e-13 | -1.33e-01 | -0.1899 |
2926 | GRSF1 | A001-C-014 | Human | Colorectum | FAP | 3.88e-03 | -6.35e-02 | 0.0135 |
2926 | GRSF1 | A002-C-016 | Human | Colorectum | FAP | 1.83e-08 | -1.02e-01 | 0.0521 |
2926 | GRSF1 | A015-C-002 | Human | Colorectum | FAP | 2.38e-02 | -1.60e-02 | -0.0763 |
2926 | GRSF1 | A001-C-203 | Human | Colorectum | FAP | 4.29e-04 | -1.10e-01 | -0.0481 |
2926 | GRSF1 | A002-C-116 | Human | Colorectum | FAP | 1.59e-13 | -1.30e-01 | -0.0452 |
2926 | GRSF1 | A014-C-008 | Human | Colorectum | FAP | 5.48e-03 | -2.07e-01 | -0.191 |
2926 | GRSF1 | A018-E-020 | Human | Colorectum | FAP | 5.97e-04 | -1.04e-01 | -0.2034 |
2926 | GRSF1 | F034 | Human | Colorectum | FAP | 5.89e-09 | -1.43e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:00311235 | Thyroid | PTC | RNA 3'-end processing | 65/5968 | 116/18723 | 6.24e-08 | 1.30e-06 | 65 |
GO:00311245 | Thyroid | PTC | mRNA 3'-end processing | 40/5968 | 62/18723 | 1.28e-07 | 2.48e-06 | 40 |
GO:00436315 | Thyroid | PTC | RNA polyadenylation | 29/5968 | 45/18723 | 7.13e-06 | 8.38e-05 | 29 |
GO:00063785 | Thyroid | PTC | mRNA polyadenylation | 28/5968 | 44/18723 | 1.46e-05 | 1.56e-04 | 28 |
GO:00163318 | Thyroid | PTC | morphogenesis of embryonic epithelium | 71/5968 | 147/18723 | 2.31e-05 | 2.29e-04 | 71 |
GO:000838034 | Thyroid | ATC | RNA splicing | 270/6293 | 434/18723 | 7.50e-35 | 1.19e-31 | 270 |
GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
GO:000640127 | Thyroid | ATC | RNA catabolic process | 165/6293 | 278/18723 | 8.45e-19 | 1.14e-16 | 165 |
GO:003447021 | Thyroid | ATC | ncRNA processing | 216/6293 | 395/18723 | 3.14e-18 | 3.98e-16 | 216 |
GO:004348435 | Thyroid | ATC | regulation of RNA splicing | 100/6293 | 148/18723 | 2.75e-17 | 2.72e-15 | 100 |
GO:003465525 | Thyroid | ATC | nucleobase-containing compound catabolic process | 217/6293 | 407/18723 | 1.20e-16 | 1.04e-14 | 217 |
GO:004670024 | Thyroid | ATC | heterocycle catabolic process | 228/6293 | 445/18723 | 7.26e-15 | 4.50e-13 | 228 |
GO:004427025 | Thyroid | ATC | cellular nitrogen compound catabolic process | 229/6293 | 451/18723 | 2.25e-14 | 1.27e-12 | 229 |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRSF1 | SNV | Missense_Mutation | rs779804453 | c.1229N>C | p.Phe410Ser | p.F410S | Q12849 | protein_coding | tolerated(0.07) | probably_damaging(0.965) | TCGA-A2-A0YE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Taxotere | SD |
GRSF1 | SNV | Missense_Mutation | novel | c.1224N>C | p.Leu408Phe | p.L408F | Q12849 | protein_coding | tolerated(0.28) | probably_damaging(0.998) | TCGA-A8-A09V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
GRSF1 | SNV | Missense_Mutation | rs779804453 | c.1229N>C | p.Phe410Ser | p.F410S | Q12849 | protein_coding | tolerated(0.07) | probably_damaging(0.965) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
GRSF1 | deletion | Frame_Shift_Del | novel | c.904delN | p.Met302TrpfsTer7 | p.M302Wfs*7 | Q12849 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GRSF1 | SNV | Missense_Mutation | novel | c.1388A>G | p.His463Arg | p.H463R | Q12849 | protein_coding | tolerated(0.13) | probably_damaging(0.929) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GRSF1 | SNV | Missense_Mutation | novel | c.478T>C | p.Ser160Pro | p.S160P | Q12849 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GRSF1 | SNV | Missense_Mutation | c.482N>A | p.Cys161Tyr | p.C161Y | Q12849 | protein_coding | deleterious(0.04) | possibly_damaging(0.9) | TCGA-C5-A7X3-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
GRSF1 | SNV | Missense_Mutation | rs775900058 | c.892N>A | p.Glu298Lys | p.E298K | Q12849 | protein_coding | tolerated(0.36) | possibly_damaging(0.446) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GRSF1 | SNV | Missense_Mutation | rs368531595 | c.641N>A | p.Arg214His | p.R214H | Q12849 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRSF1 | SNV | Missense_Mutation | c.1040N>T | p.Ala347Val | p.A347V | Q12849 | protein_coding | tolerated(0.12) | benign(0.049) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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