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Gene: GOPC |
Gene summary for GOPC |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GOPC | Gene ID | 57120 |
| Gene name | golgi associated PDZ and coiled-coil motif containing | |
| Gene Alias | CAL | |
| Cytomap | 6q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9HD26 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57120 | GOPC | LZE2T | Human | Esophagus | ESCC | 2.43e-03 | 5.90e-01 | 0.082 |
| 57120 | GOPC | LZE4T | Human | Esophagus | ESCC | 4.23e-19 | 5.10e-01 | 0.0811 |
| 57120 | GOPC | LZE7T | Human | Esophagus | ESCC | 1.39e-05 | 3.86e-01 | 0.0667 |
| 57120 | GOPC | LZE8T | Human | Esophagus | ESCC | 1.38e-10 | 3.93e-01 | 0.067 |
| 57120 | GOPC | LZE20T | Human | Esophagus | ESCC | 4.17e-07 | 2.66e-01 | 0.0662 |
| 57120 | GOPC | LZE22T | Human | Esophagus | ESCC | 2.61e-04 | 5.25e-01 | 0.068 |
| 57120 | GOPC | LZE24T | Human | Esophagus | ESCC | 9.96e-19 | 6.18e-01 | 0.0596 |
| 57120 | GOPC | LZE21T | Human | Esophagus | ESCC | 1.18e-06 | 3.03e-01 | 0.0655 |
| 57120 | GOPC | LZE6T | Human | Esophagus | ESCC | 5.38e-04 | 5.10e-01 | 0.0845 |
| 57120 | GOPC | P1T-E | Human | Esophagus | ESCC | 6.08e-10 | 7.33e-01 | 0.0875 |
| 57120 | GOPC | P2T-E | Human | Esophagus | ESCC | 4.17e-57 | 8.73e-01 | 0.1177 |
| 57120 | GOPC | P4T-E | Human | Esophagus | ESCC | 1.11e-43 | 1.03e+00 | 0.1323 |
| 57120 | GOPC | P5T-E | Human | Esophagus | ESCC | 1.78e-39 | 7.26e-01 | 0.1327 |
| 57120 | GOPC | P8T-E | Human | Esophagus | ESCC | 1.93e-36 | 7.99e-01 | 0.0889 |
| 57120 | GOPC | P9T-E | Human | Esophagus | ESCC | 2.89e-13 | 3.85e-01 | 0.1131 |
| 57120 | GOPC | P10T-E | Human | Esophagus | ESCC | 4.18e-48 | 8.53e-01 | 0.116 |
| 57120 | GOPC | P11T-E | Human | Esophagus | ESCC | 2.06e-19 | 7.60e-01 | 0.1426 |
| 57120 | GOPC | P12T-E | Human | Esophagus | ESCC | 2.38e-58 | 9.48e-01 | 0.1122 |
| 57120 | GOPC | P15T-E | Human | Esophagus | ESCC | 7.90e-36 | 8.69e-01 | 0.1149 |
| 57120 | GOPC | P16T-E | Human | Esophagus | ESCC | 2.67e-51 | 1.07e+00 | 0.1153 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000688823 | Thyroid | ATC | endoplasmic reticulum to Golgi vesicle-mediated transport | 84/6293 | 130/18723 | 4.40e-13 | 1.97e-11 | 84 |
| GO:004518532 | Thyroid | ATC | maintenance of protein location | 64/6293 | 94/18723 | 8.44e-12 | 3.16e-10 | 64 |
| GO:000689219 | Thyroid | ATC | post-Golgi vesicle-mediated transport | 68/6293 | 104/18723 | 3.30e-11 | 1.10e-09 | 68 |
| GO:000689318 | Thyroid | ATC | Golgi to plasma membrane transport | 43/6293 | 60/18723 | 1.85e-09 | 4.53e-08 | 43 |
| GO:190437526 | Thyroid | ATC | regulation of protein localization to cell periphery | 74/6293 | 125/18723 | 3.78e-09 | 8.66e-08 | 74 |
| GO:1905475111 | Thyroid | ATC | regulation of protein localization to membrane | 96/6293 | 175/18723 | 5.55e-09 | 1.22e-07 | 96 |
| GO:009887619 | Thyroid | ATC | vesicle-mediated transport to the plasma membrane | 77/6293 | 136/18723 | 2.86e-08 | 5.43e-07 | 77 |
| GO:006195123 | Thyroid | ATC | establishment of protein localization to plasma membrane | 41/6293 | 60/18723 | 4.02e-08 | 7.37e-07 | 41 |
| GO:004300117 | Thyroid | ATC | Golgi to plasma membrane protein transport | 30/6293 | 40/18723 | 1.01e-07 | 1.71e-06 | 30 |
| GO:190382816 | Thyroid | ATC | negative regulation of cellular protein localization | 67/6293 | 117/18723 | 1.23e-07 | 2.06e-06 | 67 |
| GO:190307627 | Thyroid | ATC | regulation of protein localization to plasma membrane | 61/6293 | 104/18723 | 1.38e-07 | 2.26e-06 | 61 |
| GO:005123532 | Thyroid | ATC | maintenance of location | 152/6293 | 327/18723 | 7.84e-07 | 1.04e-05 | 152 |
| GO:190307713 | Thyroid | ATC | negative regulation of protein localization to plasma membrane | 17/6293 | 24/18723 | 2.14e-04 | 1.41e-03 | 17 |
| GO:190437612 | Thyroid | ATC | negative regulation of protein localization to cell periphery | 17/6293 | 26/18723 | 9.13e-04 | 4.92e-03 | 17 |
| GO:005122014 | Thyroid | ATC | cytoplasmic sequestering of protein | 15/6293 | 22/18723 | 9.63e-04 | 5.13e-03 | 15 |
| GO:190495013 | Thyroid | ATC | negative regulation of establishment of protein localization | 61/6293 | 131/18723 | 1.38e-03 | 7.16e-03 | 61 |
| GO:005122413 | Thyroid | ATC | negative regulation of protein transport | 59/6293 | 127/18723 | 1.75e-03 | 8.71e-03 | 59 |
| GO:190547613 | Thyroid | ATC | negative regulation of protein localization to membrane | 19/6293 | 32/18723 | 2.46e-03 | 1.14e-02 | 19 |
| GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GOPC | SNV | Missense_Mutation | c.853N>A | p.Pro285Thr | p.P285T | Q9HD26 | protein_coding | tolerated(0.37) | benign(0.428) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GOPC | SNV | Missense_Mutation | c.684N>A | p.Met228Ile | p.M228I | Q9HD26 | protein_coding | tolerated(0.08) | benign(0.085) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
| GOPC | SNV | Missense_Mutation | c.294N>C | p.Leu98Phe | p.L98F | Q9HD26 | protein_coding | tolerated(0.06) | probably_damaging(0.94) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GOPC | insertion | In_Frame_Ins | novel | c.625_626insCAT | p.Lys208_Tyr209insSer | p.K208_Y209insS | Q9HD26 | protein_coding | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| GOPC | insertion | Nonsense_Mutation | novel | c.623_624insATTCCCGTATTTTTCTAAAGAAAATTAAACCTGAGGCCCCT | p.Tyr209PhefsTer9 | p.Y209Ffs*9 | Q9HD26 | protein_coding | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| GOPC | insertion | Frame_Shift_Ins | novel | c.1192_1193insA | p.Leu398TyrfsTer6 | p.L398Yfs*6 | Q9HD26 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
| GOPC | SNV | Missense_Mutation | novel | c.112N>C | p.Glu38Gln | p.E38Q | Q9HD26 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GOPC | insertion | Frame_Shift_Ins | novel | c.501dupA | p.Glu168ArgfsTer9 | p.E168Rfs*9 | Q9HD26 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
| GOPC | SNV | Missense_Mutation | novel | c.1044N>T | p.Lys348Asn | p.K348N | Q9HD26 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GOPC | SNV | Missense_Mutation | c.608C>T | p.Ala203Val | p.A203V | Q9HD26 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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