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Gene: FZR1 |
Gene summary for FZR1 |
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Gene information | Species | Human | Gene symbol | FZR1 | Gene ID | 51343 |
Gene name | fizzy and cell division cycle 20 related 1 | |
Gene Alias | CDC20C | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UM11 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51343 | FZR1 | LZE4T | Human | Esophagus | ESCC | 7.08e-03 | 7.87e-02 | 0.0811 |
51343 | FZR1 | LZE7T | Human | Esophagus | ESCC | 2.86e-05 | 2.48e-01 | 0.0667 |
51343 | FZR1 | LZE20T | Human | Esophagus | ESCC | 3.99e-04 | 1.56e-01 | 0.0662 |
51343 | FZR1 | LZE24T | Human | Esophagus | ESCC | 8.00e-05 | 1.53e-01 | 0.0596 |
51343 | FZR1 | LZE21T | Human | Esophagus | ESCC | 3.73e-05 | 3.56e-01 | 0.0655 |
51343 | FZR1 | P1T-E | Human | Esophagus | ESCC | 6.13e-14 | 4.88e-01 | 0.0875 |
51343 | FZR1 | P2T-E | Human | Esophagus | ESCC | 1.25e-14 | 1.52e-01 | 0.1177 |
51343 | FZR1 | P4T-E | Human | Esophagus | ESCC | 1.29e-12 | 1.95e-01 | 0.1323 |
51343 | FZR1 | P5T-E | Human | Esophagus | ESCC | 1.98e-19 | 2.15e-01 | 0.1327 |
51343 | FZR1 | P8T-E | Human | Esophagus | ESCC | 9.67e-17 | 1.86e-01 | 0.0889 |
51343 | FZR1 | P9T-E | Human | Esophagus | ESCC | 4.48e-09 | 2.44e-01 | 0.1131 |
51343 | FZR1 | P10T-E | Human | Esophagus | ESCC | 2.55e-15 | 2.58e-01 | 0.116 |
51343 | FZR1 | P11T-E | Human | Esophagus | ESCC | 8.78e-05 | 2.97e-01 | 0.1426 |
51343 | FZR1 | P12T-E | Human | Esophagus | ESCC | 4.23e-13 | 2.27e-01 | 0.1122 |
51343 | FZR1 | P15T-E | Human | Esophagus | ESCC | 1.87e-08 | 1.34e-01 | 0.1149 |
51343 | FZR1 | P16T-E | Human | Esophagus | ESCC | 1.97e-09 | 7.37e-02 | 0.1153 |
51343 | FZR1 | P17T-E | Human | Esophagus | ESCC | 3.21e-04 | 3.49e-01 | 0.1278 |
51343 | FZR1 | P20T-E | Human | Esophagus | ESCC | 3.36e-03 | 1.19e-01 | 0.1124 |
51343 | FZR1 | P21T-E | Human | Esophagus | ESCC | 4.27e-12 | 1.09e-01 | 0.1617 |
51343 | FZR1 | P22T-E | Human | Esophagus | ESCC | 2.25e-14 | 7.95e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903424 | Thyroid | PTC | regulation of cell aging | 29/5968 | 61/18723 | 7.57e-03 | 3.23e-02 | 29 |
GO:00447746 | Thyroid | PTC | mitotic DNA integrity checkpoint | 38/5968 | 85/18723 | 8.78e-03 | 3.66e-02 | 38 |
GO:19027502 | Thyroid | PTC | negative regulation of cell cycle G2/M phase transition | 29/5968 | 62/18723 | 9.96e-03 | 4.07e-02 | 29 |
GO:00109722 | Thyroid | PTC | negative regulation of G2/M transition of mitotic cell cycle | 28/5968 | 60/18723 | 1.16e-02 | 4.59e-02 | 28 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
GO:004217635 | Thyroid | ATC | regulation of protein catabolic process | 239/6293 | 391/18723 | 2.63e-29 | 1.85e-26 | 239 |
GO:190336235 | Thyroid | ATC | regulation of cellular protein catabolic process | 168/6293 | 255/18723 | 3.50e-26 | 1.58e-23 | 168 |
GO:190305035 | Thyroid | ATC | regulation of proteolysis involved in cellular protein catabolic process | 146/6293 | 221/18723 | 4.18e-23 | 1.20e-20 | 146 |
GO:006113633 | Thyroid | ATC | regulation of proteasomal protein catabolic process | 128/6293 | 187/18723 | 1.63e-22 | 4.30e-20 | 128 |
GO:2000058210 | Thyroid | ATC | regulation of ubiquitin-dependent protein catabolic process | 116/6293 | 164/18723 | 2.15e-22 | 5.43e-20 | 116 |
GO:0032434210 | Thyroid | ATC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/6293 | 134/18723 | 2.41e-22 | 5.86e-20 | 100 |
GO:0045732210 | Thyroid | ATC | positive regulation of protein catabolic process | 148/6293 | 231/18723 | 1.93e-21 | 4.36e-19 | 148 |
GO:190336434 | Thyroid | ATC | positive regulation of cellular protein catabolic process | 109/6293 | 155/18723 | 8.26e-21 | 1.49e-18 | 109 |
GO:190332034 | Thyroid | ATC | regulation of protein modification by small protein conjugation or removal | 152/6293 | 242/18723 | 9.76e-21 | 1.71e-18 | 152 |
GO:190180027 | Thyroid | ATC | positive regulation of proteasomal protein catabolic process | 85/6293 | 114/18723 | 3.70e-19 | 5.20e-17 | 85 |
GO:003139634 | Thyroid | ATC | regulation of protein ubiquitination | 132/6293 | 210/18723 | 3.13e-18 | 3.98e-16 | 132 |
GO:003243627 | Thyroid | ATC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 70/6293 | 90/18723 | 9.72e-18 | 1.10e-15 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FZR1 | SNV | Missense_Mutation | novel | c.668N>A | p.Cys223Tyr | p.C223Y | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-E2-A14N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
FZR1 | deletion | Frame_Shift_Del | c.1328delN | p.Tyr444ThrfsTer24 | p.Y444Tfs*24 | Q9UM11 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
FZR1 | SNV | Missense_Mutation | novel | c.823N>A | p.Gly275Arg | p.G275R | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FZR1 | SNV | Missense_Mutation | c.1135N>C | p.Asp379His | p.D379H | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
FZR1 | SNV | Missense_Mutation | c.313N>A | p.Glu105Lys | p.E105K | Q9UM11 | protein_coding | tolerated(0.33) | benign(0.015) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FZR1 | SNV | Missense_Mutation | c.661N>T | p.Arg221Trp | p.R221W | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FZR1 | SNV | Missense_Mutation | rs754635012 | c.778G>A | p.Ala260Thr | p.A260T | Q9UM11 | protein_coding | tolerated(0.39) | benign(0.006) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FZR1 | SNV | Missense_Mutation | rs760461120 | c.494N>A | p.Arg165Gln | p.R165Q | Q9UM11 | protein_coding | tolerated(0.16) | benign(0.006) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FZR1 | SNV | Missense_Mutation | c.718C>T | p.Arg240Trp | p.R240W | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FZR1 | SNV | Missense_Mutation | c.1466T>A | p.Leu489His | p.L489H | Q9UM11 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-F4-6463-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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