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Gene: FOXM1 |
Gene summary for FOXM1 |
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Gene information | Species | Human | Gene symbol | FOXM1 | Gene ID | 2305 |
Gene name | forkhead box M1 | |
Gene Alias | FKHL16 | |
Cytomap | 12p13.33 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | A0A0D9SFF0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2305 | FOXM1 | LZE2T | Human | Esophagus | ESCC | 2.95e-05 | 8.13e-01 | 0.082 |
2305 | FOXM1 | LZE6T | Human | Esophagus | ESCC | 1.92e-03 | 1.84e-01 | 0.0845 |
2305 | FOXM1 | P2T-E | Human | Esophagus | ESCC | 7.01e-13 | 5.21e-01 | 0.1177 |
2305 | FOXM1 | P4T-E | Human | Esophagus | ESCC | 7.32e-21 | 6.05e-01 | 0.1323 |
2305 | FOXM1 | P5T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.33e-01 | 0.1327 |
2305 | FOXM1 | P9T-E | Human | Esophagus | ESCC | 3.78e-05 | 1.65e-01 | 0.1131 |
2305 | FOXM1 | P10T-E | Human | Esophagus | ESCC | 7.34e-12 | 3.97e-01 | 0.116 |
2305 | FOXM1 | P15T-E | Human | Esophagus | ESCC | 1.87e-07 | 3.52e-01 | 0.1149 |
2305 | FOXM1 | P16T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.36e-01 | 0.1153 |
2305 | FOXM1 | P17T-E | Human | Esophagus | ESCC | 7.41e-03 | 2.34e-01 | 0.1278 |
2305 | FOXM1 | P20T-E | Human | Esophagus | ESCC | 2.80e-02 | 2.10e-01 | 0.1124 |
2305 | FOXM1 | P21T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.81e-01 | 0.1617 |
2305 | FOXM1 | P22T-E | Human | Esophagus | ESCC | 4.24e-18 | 6.51e-01 | 0.1236 |
2305 | FOXM1 | P24T-E | Human | Esophagus | ESCC | 2.93e-15 | 3.39e-01 | 0.1287 |
2305 | FOXM1 | P26T-E | Human | Esophagus | ESCC | 1.76e-12 | 3.38e-01 | 0.1276 |
2305 | FOXM1 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.14e-01 | 0.1055 |
2305 | FOXM1 | P28T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.57e-01 | 0.1149 |
2305 | FOXM1 | P31T-E | Human | Esophagus | ESCC | 1.30e-15 | 3.42e-01 | 0.1251 |
2305 | FOXM1 | P32T-E | Human | Esophagus | ESCC | 2.41e-29 | 5.96e-01 | 0.1666 |
2305 | FOXM1 | P36T-E | Human | Esophagus | ESCC | 8.30e-07 | 4.84e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004573911 | Thyroid | ATC | positive regulation of DNA repair | 37/6293 | 73/18723 | 1.89e-03 | 9.24e-03 | 37 |
GO:0032873110 | Thyroid | ATC | negative regulation of stress-activated MAPK cascade | 27/6293 | 51/18723 | 3.41e-03 | 1.52e-02 | 27 |
GO:0070303110 | Thyroid | ATC | negative regulation of stress-activated protein kinase signaling cascade | 27/6293 | 51/18723 | 3.41e-03 | 1.52e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421829 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421838 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421822 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421832 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421820 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa04218110 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa0421827 | Oral cavity | LP | Cellular senescence | 71/2418 | 156/8465 | 4.17e-06 | 3.75e-05 | 2.42e-05 | 71 |
hsa0421837 | Oral cavity | LP | Cellular senescence | 71/2418 | 156/8465 | 4.17e-06 | 3.75e-05 | 2.42e-05 | 71 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXM1 | SNV | Missense_Mutation | novel | c.1415N>T | p.Ser472Phe | p.S472F | Q08050 | protein_coding | deleterious(0.03) | possibly_damaging(0.739) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXM1 | SNV | Missense_Mutation | novel | c.609N>T | p.Glu203Asp | p.E203D | Q08050 | protein_coding | tolerated(0.44) | benign(0.07) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXM1 | SNV | Missense_Mutation | c.1667G>T | p.Ser556Ile | p.S556I | Q08050 | protein_coding | deleterious(0.02) | benign(0.168) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOXM1 | SNV | Missense_Mutation | c.1976N>T | p.Pro659Leu | p.P659L | Q08050 | protein_coding | tolerated(0.3) | probably_damaging(0.999) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FOXM1 | SNV | Missense_Mutation | c.361N>A | p.Leu121Ile | p.L121I | Q08050 | protein_coding | tolerated(0.43) | benign(0.117) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
FOXM1 | SNV | Missense_Mutation | novel | c.799N>C | p.Glu267Gln | p.E267Q | Q08050 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXM1 | insertion | Frame_Shift_Ins | novel | c.1030_1031insTTACAGGCATTTTTGTTTGTATCTATATTTTTTATTTATTGATG | p.Arg344LeufsTer25 | p.R344Lfs*25 | Q08050 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
FOXM1 | insertion | Nonsense_Mutation | novel | c.1413_1414insGGACCTGCTGGTTAACTTAGGCCTTTTGAGGG | p.Ser472GlyfsTer5 | p.S472Gfs*5 | Q08050 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FOXM1 | insertion | Frame_Shift_Ins | novel | c.2129_2130insCTTGCTTTTAGTTTTGATAGAAG | p.Pro711LeufsTer18 | p.P711Lfs*18 | Q08050 | protein_coding | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FOXM1 | SNV | Missense_Mutation | rs148974985 | c.1742N>A | p.Arg581Gln | p.R581Q | Q08050 | protein_coding | deleterious(0.03) | probably_damaging(0.975) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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