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Gene: FBP1 |
Gene summary for FBP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FBP1 | Gene ID | 2203 |
Gene name | fructose-bisphosphatase 1 | |
Gene Alias | FBP | |
Cytomap | 9q22.32 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P09467 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2203 | FBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.61e-02 | 3.22e-01 | -0.0811 |
2203 | FBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.96e-09 | 6.07e-01 | -0.059 |
2203 | FBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.99e-02 | 2.81e-01 | 0.096 |
2203 | FBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.50e-02 | 2.47e-01 | 0.0674 |
2203 | FBP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.05e-02 | 2.69e-01 | 0.0588 |
2203 | FBP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.08e-09 | 4.21e-01 | 0.3859 |
2203 | FBP1 | LZE24T | Human | Esophagus | ESCC | 9.58e-06 | 2.63e-01 | 0.0596 |
2203 | FBP1 | P8T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.91e-01 | 0.0889 |
2203 | FBP1 | P28T-E | Human | Esophagus | ESCC | 5.15e-11 | 3.01e-01 | 0.1149 |
2203 | FBP1 | P57T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.06e-01 | 0.0926 |
2203 | FBP1 | P74T-E | Human | Esophagus | ESCC | 3.83e-04 | 2.67e-01 | 0.1479 |
2203 | FBP1 | P75T-E | Human | Esophagus | ESCC | 2.70e-39 | 1.11e+00 | 0.1125 |
2203 | FBP1 | P76T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.24e-01 | 0.1207 |
2203 | FBP1 | P82T-E | Human | Esophagus | ESCC | 9.61e-07 | 5.53e-01 | 0.1072 |
2203 | FBP1 | P94T-E | Human | Esophagus | ESCC | 1.55e-13 | 1.76e+00 | 0.0879 |
2203 | FBP1 | P104T-E | Human | Esophagus | ESCC | 3.89e-05 | 4.92e-01 | 0.0931 |
2203 | FBP1 | P130T-E | Human | Esophagus | ESCC | 1.75e-25 | 5.56e-01 | 0.1676 |
2203 | FBP1 | NAFLD1 | Human | Liver | NAFLD | 4.79e-07 | 5.92e-01 | -0.04 |
2203 | FBP1 | S43 | Human | Liver | Cirrhotic | 1.95e-17 | -2.48e-01 | -0.0187 |
2203 | FBP1 | HCC1_Meng | Human | Liver | HCC | 5.66e-30 | -4.31e-01 | 0.0246 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000913520 | Esophagus | ESCC | purine nucleoside diphosphate metabolic process | 63/8552 | 103/18723 | 1.10e-03 | 5.52e-03 | 63 |
GO:000917920 | Esophagus | ESCC | purine ribonucleoside diphosphate metabolic process | 63/8552 | 103/18723 | 1.10e-03 | 5.52e-03 | 63 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
GO:00193193 | Esophagus | ESCC | hexose biosynthetic process | 49/8552 | 78/18723 | 1.69e-03 | 7.81e-03 | 49 |
GO:00061096 | Esophagus | ESCC | regulation of carbohydrate metabolic process | 101/8552 | 178/18723 | 1.89e-03 | 8.52e-03 | 101 |
GO:004693919 | Esophagus | ESCC | nucleotide phosphorylation | 61/8552 | 101/18723 | 2.03e-03 | 9.08e-03 | 61 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:004603119 | Esophagus | ESCC | ADP metabolic process | 55/8552 | 90/18723 | 2.27e-03 | 9.99e-03 | 55 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:000609019 | Esophagus | ESCC | pyruvate metabolic process | 63/8552 | 106/18723 | 2.98e-03 | 1.24e-02 | 63 |
GO:000616519 | Esophagus | ESCC | nucleoside diphosphate phosphorylation | 59/8552 | 99/18723 | 3.65e-03 | 1.49e-02 | 59 |
GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
GO:00060943 | Esophagus | ESCC | gluconeogenesis | 46/8552 | 75/18723 | 4.54e-03 | 1.78e-02 | 46 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
GO:009013220 | Esophagus | ESCC | epithelium migration | 188/8552 | 360/18723 | 6.96e-03 | 2.54e-02 | 188 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:004347010 | Esophagus | ESCC | regulation of carbohydrate catabolic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:000609620 | Esophagus | ESCC | glycolytic process | 48/8552 | 81/18723 | 9.54e-03 | 3.30e-02 | 48 |
GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa049224 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa04910 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa000105 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa049225 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa049101 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBP1 | SNV | Missense_Mutation | novel | c.1007N>T | p.Ser336Phe | p.S336F | P09467 | protein_coding | deleterious(0.01) | benign(0.284) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBP1 | SNV | Missense_Mutation | c.747N>A | p.Met249Ile | p.M249I | P09467 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
FBP1 | SNV | Missense_Mutation | novel | c.145G>C | p.Val49Leu | p.V49L | P09467 | protein_coding | deleterious(0.02) | benign(0.366) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
FBP1 | SNV | Missense_Mutation | novel | c.923N>T | p.Pro308Leu | p.P308L | P09467 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AR-A5QM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | PD |
FBP1 | SNV | Missense_Mutation | novel | c.323N>A | p.Pro108Gln | p.P108Q | P09467 | protein_coding | tolerated(0.21) | benign(0.028) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FBP1 | SNV | Missense_Mutation | novel | c.299N>C | p.Asp100Ala | p.D100A | P09467 | protein_coding | tolerated(0.05) | benign(0.069) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FBP1 | SNV | Missense_Mutation | c.88N>A | p.Glu30Lys | p.E30K | P09467 | protein_coding | deleterious(0) | benign(0.247) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBP1 | SNV | Missense_Mutation | novel | c.931N>G | p.Ile311Val | p.I311V | P09467 | protein_coding | deleterious(0.02) | possibly_damaging(0.47) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBP1 | deletion | Frame_Shift_Del | c.881delN | p.Gly294GlufsTer11 | p.G294Efs*11 | P09467 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FBP1 | SNV | Missense_Mutation | novel | c.1010N>T | p.Ala337Val | p.A337V | P09467 | protein_coding | tolerated(0.08) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | MB07803 | MB-07803 | ||
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | MB07803 | MB-07803 | ||
2203 | FBP1 | DRUGGABLE GENOME, ENZYME | Managlinat dialanetil |
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