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Gene: FAM107A |
Gene summary for FAM107A |
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Gene information | Species | Human | Gene symbol | FAM107A | Gene ID | 11170 |
Gene name | family with sequence similarity 107 member A | |
Gene Alias | DRR1 | |
Cytomap | 3p14.3-p14.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | O95990 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11170 | FAM107A | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 2.66e-02 | -1.43e-01 | -0.1433 |
11170 | FAM107A | 047563_1562-all-cells | Human | Prostate | BPH | 3.06e-04 | -1.57e-01 | 0.0791 |
11170 | FAM107A | 048752_1579-all-cells | Human | Prostate | BPH | 1.71e-02 | -1.41e-01 | 0.1008 |
11170 | FAM107A | 052095_1628-all-cells | Human | Prostate | BPH | 4.66e-02 | -1.13e-01 | 0.1032 |
11170 | FAM107A | Dong_P1 | Human | Prostate | Tumor | 5.99e-06 | -1.87e-01 | 0.035 |
11170 | FAM107A | Dong_P3 | Human | Prostate | Tumor | 7.79e-05 | 2.77e-02 | 0.0278 |
11170 | FAM107A | Dong_P5 | Human | Prostate | Tumor | 3.90e-04 | -1.84e-01 | 0.053 |
11170 | FAM107A | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 9.19e-08 | 8.30e-01 | 0.1608 |
11170 | FAM107A | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 2.05e-05 | 8.82e-01 | 0.1622 |
11170 | FAM107A | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.76e-05 | 4.39e-01 | 0.1575 |
11170 | FAM107A | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 7.02e-12 | 6.45e-01 | 0.1545 |
11170 | FAM107A | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 6.18e-12 | 7.04e-01 | 0.1569 |
11170 | FAM107A | male-WTA | Human | Thyroid | PTC | 2.08e-06 | 6.76e-02 | 0.1037 |
11170 | FAM107A | PTC05 | Human | Thyroid | PTC | 1.89e-03 | 2.22e-01 | 0.2065 |
11170 | FAM107A | PTC06 | Human | Thyroid | PTC | 1.53e-12 | 2.37e-01 | 0.2057 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19019885 | Thyroid | PTC | negative regulation of cell cycle phase transition | 104/5968 | 249/18723 | 6.01e-04 | 3.82e-03 | 104 |
GO:20001345 | Thyroid | PTC | negative regulation of G1/S transition of mitotic cell cycle | 39/5968 | 84/18723 | 3.66e-03 | 1.76e-02 | 39 |
GO:0031960111 | Thyroid | PTC | response to corticosteroid | 69/5968 | 167/18723 | 6.18e-03 | 2.74e-02 | 69 |
GO:0051384111 | Thyroid | PTC | response to glucocorticoid | 62/5968 | 148/18723 | 6.39e-03 | 2.81e-02 | 62 |
GO:000716219 | Thyroid | PTC | negative regulation of cell adhesion | 117/5968 | 303/18723 | 7.28e-03 | 3.12e-02 | 117 |
GO:00518953 | Thyroid | PTC | negative regulation of focal adhesion assembly | 11/5968 | 18/18723 | 1.00e-02 | 4.07e-02 | 11 |
GO:01501183 | Thyroid | PTC | negative regulation of cell-substrate junction organization | 11/5968 | 18/18723 | 1.00e-02 | 4.07e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM107A | SNV | Missense_Mutation | c.384N>C | p.Glu128Asp | p.E128D | O95990 | protein_coding | deleterious(0.04) | possibly_damaging(0.769) | TCGA-BH-A18R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM107A | SNV | Missense_Mutation | c.408G>C | p.Gln136His | p.Q136H | O95990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
FAM107A | SNV | Missense_Mutation | rs373429682 | c.91G>A | p.Ala31Thr | p.A31T | O95990 | protein_coding | tolerated(0.06) | benign(0.05) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM107A | SNV | Missense_Mutation | c.119N>A | p.Arg40Gln | p.R40Q | O95990 | protein_coding | tolerated(0.56) | benign(0.031) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM107A | SNV | Missense_Mutation | rs753821366 | c.487N>T | p.Arg163Trp | p.R163W | O95990 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM107A | SNV | Missense_Mutation | novel | c.191N>G | p.Lys64Arg | p.K64R | O95990 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM107A | SNV | Missense_Mutation | novel | c.184C>T | p.Pro62Ser | p.P62S | O95990 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM107A | SNV | Missense_Mutation | c.172N>A | p.Glu58Lys | p.E58K | O95990 | protein_coding | deleterious(0.01) | possibly_damaging(0.64) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM107A | SNV | Missense_Mutation | rs755089230 | c.400N>T | p.Arg134Trp | p.R134W | O95990 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM107A | SNV | Missense_Mutation | c.141G>T | p.Met47Ile | p.M47I | O95990 | protein_coding | deleterious(0.05) | benign(0.281) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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