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Gene: EREG |
Gene summary for EREG |
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Gene information | Species | Human | Gene symbol | EREG | Gene ID | 2069 |
Gene name | epiregulin | |
Gene Alias | EPR | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O14944 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2069 | EREG | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.14e-20 | 6.70e-01 | 0.3859 |
2069 | EREG | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.54e-12 | 2.76e-01 | 0.3005 |
2069 | EREG | A001-C-007 | Human | Colorectum | CRC | 2.82e-05 | 4.32e-01 | 0.1899 |
2069 | EREG | CRC-3-11773 | Human | Colorectum | CRC | 3.33e-43 | 9.81e-01 | 0.2564 |
2069 | EREG | LZE4T | Human | Esophagus | ESCC | 2.49e-12 | -8.76e-01 | 0.0811 |
2069 | EREG | LZE5T | Human | Esophagus | ESCC | 2.07e-15 | -5.96e-01 | 0.0514 |
2069 | EREG | LZE7T | Human | Esophagus | ESCC | 3.97e-06 | -8.76e-01 | 0.0667 |
2069 | EREG | LZE8T | Human | Esophagus | ESCC | 8.52e-07 | -7.32e-01 | 0.067 |
2069 | EREG | LZE20T | Human | Esophagus | ESCC | 2.57e-11 | -8.76e-01 | 0.0662 |
2069 | EREG | LZE22D1 | Human | Esophagus | HGIN | 6.87e-06 | -8.76e-01 | 0.0595 |
2069 | EREG | LZE24T | Human | Esophagus | ESCC | 4.87e-17 | -8.68e-01 | 0.0596 |
2069 | EREG | P1T-E | Human | Esophagus | ESCC | 6.09e-15 | -7.11e-01 | 0.0875 |
2069 | EREG | P2T-E | Human | Esophagus | ESCC | 7.21e-26 | -8.68e-01 | 0.1177 |
2069 | EREG | P4T-E | Human | Esophagus | ESCC | 1.40e-14 | -8.24e-01 | 0.1323 |
2069 | EREG | P5T-E | Human | Esophagus | ESCC | 2.87e-23 | -8.58e-01 | 0.1327 |
2069 | EREG | P8T-E | Human | Esophagus | ESCC | 2.27e-06 | -6.03e-01 | 0.0889 |
2069 | EREG | P9T-E | Human | Esophagus | ESCC | 6.97e-18 | -8.69e-01 | 0.1131 |
2069 | EREG | P10T-E | Human | Esophagus | ESCC | 3.02e-26 | -8.76e-01 | 0.116 |
2069 | EREG | P11T-E | Human | Esophagus | ESCC | 4.43e-07 | -4.10e-01 | 0.1426 |
2069 | EREG | P12T-E | Human | Esophagus | ESCC | 3.02e-26 | -8.67e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000283112 | Oral cavity | LP | regulation of response to biotic stimulus | 109/4623 | 327/18723 | 2.45e-04 | 2.60e-03 | 109 |
GO:004361612 | Oral cavity | LP | keratinocyte proliferation | 22/4623 | 46/18723 | 5.55e-04 | 5.13e-03 | 22 |
GO:003021613 | Oral cavity | LP | keratinocyte differentiation | 51/4623 | 139/18723 | 1.05e-03 | 8.84e-03 | 51 |
GO:000991315 | Oral cavity | LP | epidermal cell differentiation | 69/4623 | 202/18723 | 1.53e-03 | 1.19e-02 | 69 |
GO:004814413 | Oral cavity | LP | fibroblast proliferation | 32/4623 | 81/18723 | 2.24e-03 | 1.62e-02 | 32 |
GO:004814513 | Oral cavity | LP | regulation of fibroblast proliferation | 31/4623 | 80/18723 | 3.69e-03 | 2.44e-02 | 31 |
GO:190118412 | Oral cavity | LP | regulation of ERBB signaling pathway | 30/4623 | 79/18723 | 5.97e-03 | 3.54e-02 | 30 |
GO:004828511 | Oral cavity | LP | organelle fission | 145/4623 | 488/18723 | 6.02e-03 | 3.57e-02 | 145 |
GO:00092991 | Oral cavity | LP | mRNA transcription | 9/4623 | 16/18723 | 6.82e-03 | 3.94e-02 | 9 |
GO:006145818 | Oral cavity | LP | reproductive system development | 128/4623 | 427/18723 | 6.91e-03 | 3.96e-02 | 128 |
GO:004814611 | Oral cavity | LP | positive regulation of fibroblast proliferation | 20/4623 | 48/18723 | 7.17e-03 | 4.02e-02 | 20 |
GO:004860817 | Oral cavity | LP | reproductive structure development | 127/4623 | 424/18723 | 7.31e-03 | 4.08e-02 | 127 |
GO:00070881 | Oral cavity | LP | regulation of mitotic nuclear division | 39/4623 | 110/18723 | 7.45e-03 | 4.14e-02 | 39 |
GO:003812716 | Oral cavity | LP | ERBB signaling pathway | 42/4623 | 121/18723 | 8.53e-03 | 4.61e-02 | 42 |
GO:004578715 | Oral cavity | LP | positive regulation of cell cycle | 96/4623 | 313/18723 | 9.08e-03 | 4.85e-02 | 96 |
GO:014001415 | Skin | cSCC | mitotic nuclear division | 149/4864 | 287/18723 | 3.59e-21 | 6.43e-19 | 149 |
GO:000734617 | Skin | cSCC | regulation of mitotic cell cycle | 192/4864 | 457/18723 | 3.47e-14 | 2.31e-12 | 192 |
GO:00482854 | Skin | cSCC | organelle fission | 197/4864 | 488/18723 | 1.51e-12 | 8.36e-11 | 197 |
GO:00002803 | Skin | cSCC | nuclear division | 178/4864 | 439/18723 | 1.17e-11 | 5.93e-10 | 178 |
GO:004358823 | Skin | cSCC | skin development | 111/4864 | 263/18723 | 6.35e-09 | 2.10e-07 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052102 | Colorectum | MSS | Colorectal cancer | 36/1875 | 86/8465 | 3.08e-05 | 3.22e-04 | 1.97e-04 | 36 |
hsa040122 | Colorectum | MSS | ErbB signaling pathway | 30/1875 | 85/8465 | 3.73e-03 | 1.67e-02 | 1.02e-02 | 30 |
hsa052103 | Colorectum | MSS | Colorectal cancer | 36/1875 | 86/8465 | 3.08e-05 | 3.22e-04 | 1.97e-04 | 36 |
hsa040123 | Colorectum | MSS | ErbB signaling pathway | 30/1875 | 85/8465 | 3.73e-03 | 1.67e-02 | 1.02e-02 | 30 |
hsa040126 | Colorectum | CRC | ErbB signaling pathway | 24/1091 | 85/8465 | 1.23e-04 | 1.79e-03 | 1.21e-03 | 24 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa040127 | Colorectum | CRC | ErbB signaling pathway | 24/1091 | 85/8465 | 1.23e-04 | 1.79e-03 | 1.21e-03 | 24 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa0521020 | Esophagus | ESCC | Colorectal cancer | 69/4205 | 86/8465 | 4.06e-09 | 4.13e-08 | 2.11e-08 | 69 |
hsa0401218 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa05210110 | Esophagus | ESCC | Colorectal cancer | 69/4205 | 86/8465 | 4.06e-09 | 4.13e-08 | 2.11e-08 | 69 |
hsa0401219 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0521018 | Oral cavity | OSCC | Colorectal cancer | 66/3704 | 86/8465 | 3.99e-10 | 4.95e-09 | 2.52e-09 | 66 |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0401216 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
EREG | EGFR | EREG_EGFR | EGF | Breast | DCIS |
EREG | EGFR_ERBB2 | EREG_EGFR_ERBB2 | EGF | Breast | DCIS |
EREG | EGFR | EREG_EGFR | EGF | Breast | Healthy |
EREG | EGFR | EREG_EGFR | EGF | Breast | Precancer |
EREG | EGFR | EREG_EGFR | EGF | Cervix | Precancer |
EREG | EGFR | EREG_EGFR | EGF | Endometrium | ADJ |
EREG | ERBB4 | EREG_ERBB4 | EGF | Endometrium | ADJ |
EREG | EGFR | EREG_EGFR | EGF | Endometrium | AEH |
EREG | ERBB4 | EREG_ERBB4 | EGF | Endometrium | AEH |
EREG | EGFR | EREG_EGFR | EGF | Endometrium | EEC |
EREG | ERBB4 | EREG_ERBB4 | EGF | Endometrium | EEC |
EREG | EGFR | EREG_EGFR | EGF | Endometrium | Healthy |
EREG | EGFR | EREG_EGFR | EGF | HNSCC | ADJ |
EREG | EGFR_ERBB2 | EREG_EGFR_ERBB2 | EGF | HNSCC | ADJ |
EREG | EGFR | EREG_EGFR | EGF | HNSCC | Healthy |
EREG | EGFR | EREG_EGFR | EGF | HNSCC | OSCC |
EREG | EGFR_ERBB2 | EREG_EGFR_ERBB2 | EGF | HNSCC | OSCC |
EREG | EGFR | EREG_EGFR | EGF | HNSCC | Precancer |
EREG | EGFR_ERBB2 | EREG_EGFR_ERBB2 | EGF | HNSCC | Precancer |
EREG | EGFR | EREG_EGFR | EGF | Liver | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EREG | insertion | Frame_Shift_Ins | novel | c.356_357insTCTCA | p.Ala120LeufsTer4 | p.A120Lfs*4 | O14944 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
EREG | insertion | Nonsense_Mutation | novel | c.357_358insTTCTGAAATTCGTTATTCCCCAAA | p.Val119_Ala120insPheTerAsnSerLeuPheProLys | p.V119_A120insF*NSLFPK | O14944 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
EREG | insertion | Frame_Shift_Ins | novel | c.174_175insT | p.Arg59SerfsTer11 | p.R59Sfs*11 | O14944 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
EREG | insertion | Frame_Shift_Ins | novel | c.175_176insTCTTGAACATGTACTATGTACCA | p.Arg59LeufsTer15 | p.R59Lfs*15 | O14944 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
EREG | SNV | Missense_Mutation | novel | c.434G>A | p.Arg145Lys | p.R145K | O14944 | protein_coding | tolerated(0.68) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EREG | SNV | Missense_Mutation | novel | c.403G>A | p.Gly135Ser | p.G135S | O14944 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EREG | SNV | Missense_Mutation | novel | c.318N>A | p.Phe106Leu | p.F106L | O14944 | protein_coding | tolerated(1) | benign(0.019) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EREG | SNV | Missense_Mutation | novel | c.11N>A | p.Gly4Glu | p.G4E | O14944 | protein_coding | tolerated_low_confidence(0.86) | benign(0.001) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EREG | SNV | Missense_Mutation | novel | c.242N>A | p.Cys81Tyr | p.C81Y | O14944 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
EREG | SNV | Missense_Mutation | novel | c.24G>T | p.Glu8Asp | p.E8D | O14944 | protein_coding | tolerated_low_confidence(0.32) | benign(0.003) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | cetuximab | CETUXIMAB | ||
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | CETUXIMAB | CETUXIMAB | 23374602 | |
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | PANITUMUMAB | PANITUMUMAB | 26867820 | |
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | panitumumab | PANITUMUMAB | ||
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | HUMAN CHORIONIC GONADOTROPIN | 16543407 | ||
2069 | EREG | KINASE, GROWTH FACTOR, DRUGGABLE GENOME | LY3016859 |
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