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Gene: ENTPD5 |
Gene summary for ENTPD5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ENTPD5 | Gene ID | 957 |
| Gene name | ectonucleoside triphosphate diphosphohydrolase 5 (inactive) | |
| Gene Alias | CD39L4 | |
| Cytomap | 14q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024R6D3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 957 | ENTPD5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.15e-09 | -4.60e-01 | 0.0155 |
| 957 | ENTPD5 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.69e-10 | 5.71e-01 | -0.1954 |
| 957 | ENTPD5 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.88e-07 | -4.30e-01 | 0.096 |
| 957 | ENTPD5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.03e-02 | -2.66e-01 | 0.0674 |
| 957 | ENTPD5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.61e-05 | -5.64e-01 | 0.0588 |
| 957 | ENTPD5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.26e-17 | -5.12e-01 | 0.294 |
| 957 | ENTPD5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.43e-04 | -5.01e-01 | 0.281 |
| 957 | ENTPD5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.33e-17 | -5.06e-01 | 0.3859 |
| 957 | ENTPD5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.19e-03 | -5.48e-01 | 0.2585 |
| 957 | ENTPD5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.96e-22 | -5.54e-01 | 0.3005 |
| 957 | ENTPD5 | F007 | Human | Colorectum | FAP | 2.12e-02 | -2.97e-01 | 0.1176 |
| 957 | ENTPD5 | A002-C-010 | Human | Colorectum | FAP | 2.02e-03 | -2.40e-01 | 0.242 |
| 957 | ENTPD5 | A001-C-207 | Human | Colorectum | FAP | 2.23e-04 | -3.93e-01 | 0.1278 |
| 957 | ENTPD5 | A015-C-203 | Human | Colorectum | FAP | 3.03e-24 | -4.65e-01 | -0.1294 |
| 957 | ENTPD5 | A015-C-204 | Human | Colorectum | FAP | 2.23e-06 | -3.14e-01 | -0.0228 |
| 957 | ENTPD5 | A014-C-040 | Human | Colorectum | FAP | 1.84e-03 | -4.17e-01 | -0.1184 |
| 957 | ENTPD5 | A002-C-201 | Human | Colorectum | FAP | 4.29e-13 | -4.38e-01 | 0.0324 |
| 957 | ENTPD5 | A002-C-203 | Human | Colorectum | FAP | 6.02e-08 | -2.96e-01 | 0.2786 |
| 957 | ENTPD5 | A001-C-119 | Human | Colorectum | FAP | 1.54e-11 | -5.33e-01 | -0.1557 |
| 957 | ENTPD5 | A001-C-108 | Human | Colorectum | FAP | 5.23e-19 | -3.84e-01 | -0.0272 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00460345 | Colorectum | CRC | ATP metabolic process | 51/2078 | 277/18723 | 1.92e-04 | 3.30e-03 | 51 |
| GO:00194395 | Colorectum | CRC | aromatic compound catabolic process | 77/2078 | 467/18723 | 2.42e-04 | 4.00e-03 | 77 |
| GO:00067535 | Colorectum | CRC | nucleoside phosphate metabolic process | 81/2078 | 497/18723 | 2.48e-04 | 4.06e-03 | 81 |
| GO:00060915 | Colorectum | CRC | generation of precursor metabolites and energy | 80/2078 | 490/18723 | 2.55e-04 | 4.16e-03 | 80 |
| GO:00434703 | Colorectum | CRC | regulation of carbohydrate catabolic process | 16/2078 | 56/18723 | 2.72e-04 | 4.37e-03 | 16 |
| GO:19013615 | Colorectum | CRC | organic cyclic compound catabolic process | 80/2078 | 495/18723 | 3.52e-04 | 5.34e-03 | 80 |
| GO:00458211 | Colorectum | CRC | positive regulation of glycolytic process | 8/2078 | 19/18723 | 5.55e-04 | 7.70e-03 | 8 |
| GO:19005422 | Colorectum | CRC | regulation of purine nucleotide metabolic process | 20/2078 | 84/18723 | 7.13e-04 | 9.24e-03 | 20 |
| GO:00061401 | Colorectum | CRC | regulation of nucleotide metabolic process | 20/2078 | 86/18723 | 9.78e-04 | 1.17e-02 | 20 |
| GO:19035785 | Colorectum | CRC | regulation of ATP metabolic process | 20/2078 | 87/18723 | 1.14e-03 | 1.31e-02 | 20 |
| GO:00620132 | Colorectum | CRC | positive regulation of small molecule metabolic process | 27/2078 | 143/18723 | 3.97e-03 | 3.29e-02 | 27 |
| GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
| GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
| GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
| GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
| GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
| GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
| GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
| GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
| GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ENTPD5 | SNV | Missense_Mutation | c.1183N>C | p.Asp395His | p.D395H | O75356 | protein_coding | deleterious(0.04) | possibly_damaging(0.781) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ENTPD5 | SNV | Missense_Mutation | c.412G>C | p.Glu138Gln | p.E138Q | O75356 | protein_coding | tolerated(0.21) | possibly_damaging(0.751) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ENTPD5 | SNV | Missense_Mutation | novel | c.804N>G | p.Phe268Leu | p.F268L | O75356 | protein_coding | tolerated(1) | probably_damaging(0.998) | TCGA-GM-A3NW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
| ENTPD5 | insertion | Nonsense_Mutation | novel | c.519_520insTATTTAGAGCTGGCTCTCATTTGACAGGTCAGCTGCATG | p.Gly173_Ile174insTyrLeuGluLeuAlaLeuIleTerGlnValSerCysMet | p.G173_I174insYLELALI*QVSCM | O75356 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
| ENTPD5 | SNV | Missense_Mutation | rs757235389 | c.134N>T | p.Ala45Val | p.A45V | O75356 | protein_coding | tolerated(0.27) | benign(0.037) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ENTPD5 | SNV | Missense_Mutation | novel | c.596A>T | p.Asp199Val | p.D199V | O75356 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
| ENTPD5 | SNV | Missense_Mutation | novel | c.987C>A | p.Phe329Leu | p.F329L | O75356 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ENTPD5 | SNV | Missense_Mutation | novel | c.987N>A | p.Phe329Leu | p.F329L | O75356 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| ENTPD5 | SNV | Missense_Mutation | novel | c.1241N>C | p.Leu414Ser | p.L414S | O75356 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| ENTPD5 | SNV | Missense_Mutation | novel | c.983C>T | p.Ala328Val | p.A328V | O75356 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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