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Gene: EIF4E |
Gene summary for EIF4E |
Gene summary. |
Gene information | Species | Human | Gene symbol | EIF4E | Gene ID | 1977 |
Gene name | eukaryotic translation initiation factor 4E | |
Gene Alias | AUTS19 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | P06730 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1977 | EIF4E | LZE2T | Human | Esophagus | ESCC | 1.23e-03 | 4.59e-01 | 0.082 |
1977 | EIF4E | LZE4T | Human | Esophagus | ESCC | 4.05e-14 | 5.47e-01 | 0.0811 |
1977 | EIF4E | LZE5T | Human | Esophagus | ESCC | 3.39e-08 | 2.26e-01 | 0.0514 |
1977 | EIF4E | LZE7T | Human | Esophagus | ESCC | 3.67e-04 | 4.52e-01 | 0.0667 |
1977 | EIF4E | LZE8T | Human | Esophagus | ESCC | 2.20e-09 | 5.09e-01 | 0.067 |
1977 | EIF4E | LZE20T | Human | Esophagus | ESCC | 1.73e-05 | 1.76e-01 | 0.0662 |
1977 | EIF4E | LZE22T | Human | Esophagus | ESCC | 5.18e-04 | 3.37e-01 | 0.068 |
1977 | EIF4E | LZE24T | Human | Esophagus | ESCC | 5.04e-14 | 3.21e-01 | 0.0596 |
1977 | EIF4E | LZE6T | Human | Esophagus | ESCC | 7.24e-06 | 4.77e-01 | 0.0845 |
1977 | EIF4E | P1T-E | Human | Esophagus | ESCC | 4.08e-06 | 3.92e-01 | 0.0875 |
1977 | EIF4E | P2T-E | Human | Esophagus | ESCC | 1.05e-29 | 6.89e-01 | 0.1177 |
1977 | EIF4E | P4T-E | Human | Esophagus | ESCC | 1.42e-40 | 1.19e+00 | 0.1323 |
1977 | EIF4E | P5T-E | Human | Esophagus | ESCC | 2.50e-14 | 5.14e-01 | 0.1327 |
1977 | EIF4E | P8T-E | Human | Esophagus | ESCC | 1.76e-17 | 3.62e-01 | 0.0889 |
1977 | EIF4E | P9T-E | Human | Esophagus | ESCC | 8.47e-19 | 4.50e-01 | 0.1131 |
1977 | EIF4E | P10T-E | Human | Esophagus | ESCC | 1.84e-22 | 3.89e-01 | 0.116 |
1977 | EIF4E | P11T-E | Human | Esophagus | ESCC | 2.46e-21 | 1.08e+00 | 0.1426 |
1977 | EIF4E | P12T-E | Human | Esophagus | ESCC | 1.62e-30 | 6.71e-01 | 0.1122 |
1977 | EIF4E | P15T-E | Human | Esophagus | ESCC | 1.53e-34 | 8.67e-01 | 0.1149 |
1977 | EIF4E | P16T-E | Human | Esophagus | ESCC | 5.33e-39 | 7.34e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:0036293111 | Esophagus | ESCC | response to decreased oxygen levels | 201/8552 | 322/18723 | 8.37e-10 | 2.04e-08 | 201 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:0001666111 | Esophagus | ESCC | response to hypoxia | 192/8552 | 307/18723 | 1.59e-09 | 3.69e-08 | 192 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:004593116 | Esophagus | ESCC | positive regulation of mitotic cell cycle | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:0071453110 | Esophagus | ESCC | cellular response to oxygen levels | 114/8552 | 177/18723 | 3.63e-07 | 5.06e-06 | 114 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:0036294110 | Esophagus | ESCC | cellular response to decreased oxygen levels | 105/8552 | 161/18723 | 4.20e-07 | 5.73e-06 | 105 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:007145616 | Esophagus | ESCC | cellular response to hypoxia | 97/8552 | 151/18723 | 3.12e-06 | 3.51e-05 | 97 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
GO:003286818 | Esophagus | ESCC | response to insulin | 156/8552 | 264/18723 | 7.21e-06 | 7.20e-05 | 156 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0152110 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0421114 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0152115 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0421115 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0491021 | Liver | Cirrhotic | Insulin signaling pathway | 56/2530 | 137/8465 | 3.74e-03 | 1.50e-02 | 9.26e-03 | 56 |
hsa0406612 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa015216 | Liver | Cirrhotic | EGFR tyrosine kinase inhibitor resistance | 35/2530 | 79/8465 | 4.50e-03 | 1.70e-02 | 1.05e-02 | 35 |
hsa042118 | Liver | Cirrhotic | Longevity regulating pathway | 37/2530 | 89/8465 | 1.22e-02 | 3.89e-02 | 2.40e-02 | 37 |
hsa0491031 | Liver | Cirrhotic | Insulin signaling pathway | 56/2530 | 137/8465 | 3.74e-03 | 1.50e-02 | 9.26e-03 | 56 |
hsa0406613 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa0152111 | Liver | Cirrhotic | EGFR tyrosine kinase inhibitor resistance | 35/2530 | 79/8465 | 4.50e-03 | 1.70e-02 | 1.05e-02 | 35 |
hsa0421111 | Liver | Cirrhotic | Longevity regulating pathway | 37/2530 | 89/8465 | 1.22e-02 | 3.89e-02 | 2.40e-02 | 37 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4E | SNV | Missense_Mutation | rs776434815 | c.383G>A | p.Arg128His | p.R128H | P06730 | protein_coding | tolerated(0.15) | benign(0.02) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF4E | SNV | Missense_Mutation | novel | c.182N>A | p.Arg61Gln | p.R61Q | P06730 | protein_coding | tolerated(0.25) | benign(0.058) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | novel | c.21N>C | p.Glu7Asp | p.E7D | P06730 | protein_coding | tolerated_low_confidence(0.24) | probably_damaging(0.979) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EIF4E | SNV | Missense_Mutation | rs772918368 | c.65C>T | p.Thr22Met | p.T22M | P06730 | protein_coding | tolerated(0.07) | possibly_damaging(0.847) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | rs17850950 | c.379G>A | p.Asp127Asn | p.D127N | P06730 | protein_coding | deleterious(0.03) | possibly_damaging(0.636) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | rs776434815 | c.383N>A | p.Arg128His | p.R128H | P06730 | protein_coding | tolerated(0.15) | benign(0.02) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | novel | c.547G>A | p.Ala183Thr | p.A183T | P06730 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | novel | c.539N>C | p.Val180Ala | p.V180A | P06730 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | rs200243582 | c.694N>A | p.Ala232Thr | p.A232T | P06730 | protein_coding | tolerated(0.18) | benign(0.031) | TCGA-BC-A69I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EIF4E | SNV | Missense_Mutation | c.661C>T | p.Pro221Ser | p.P221S | P06730 | protein_coding | tolerated(0.98) | benign(0.061) | TCGA-49-4510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1977 | EIF4E | DRUGGABLE GENOME | ETOPOSIDE | ETOPOSIDE | 11956083 | |
1977 | EIF4E | DRUGGABLE GENOME | H2O2 | 12151318 | ||
1977 | EIF4E | DRUGGABLE GENOME | LY2275796 | |||
1977 | EIF4E | DRUGGABLE GENOME | MTOR INHIBITOR | 15190216 | ||
1977 | EIF4E | DRUGGABLE GENOME | inhibitor | ISIS-EIF4ERX | ||
1977 | EIF4E | DRUGGABLE GENOME | RAPAMYCIN | SIROLIMUS | 10516161,8816458,10477262,15292274,14581487,9867830 | |
1977 | EIF4E | DRUGGABLE GENOME | HYDROXYUREA | HYDROXYUREA | 10585489 |
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