Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00616472 | Prostate | BPH | histone H3-K9 modification | 16/3107 | 48/18723 | 3.45e-03 | 1.77e-02 | 16 |
GO:001657013 | Prostate | Tumor | histone modification | 126/3246 | 463/18723 | 5.51e-08 | 1.65e-06 | 126 |
GO:001820512 | Prostate | Tumor | peptidyl-lysine modification | 99/3246 | 376/18723 | 6.77e-06 | 1.02e-04 | 99 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000963617 | Prostate | Tumor | response to toxic substance | 70/3246 | 262/18723 | 8.76e-05 | 8.66e-04 | 70 |
GO:000647912 | Prostate | Tumor | protein methylation | 52/3246 | 181/18723 | 9.58e-05 | 9.35e-04 | 52 |
GO:000821312 | Prostate | Tumor | protein alkylation | 52/3246 | 181/18723 | 9.58e-05 | 9.35e-04 | 52 |
GO:001657112 | Prostate | Tumor | histone methylation | 41/3246 | 141/18723 | 3.79e-04 | 2.95e-03 | 41 |
GO:003496812 | Prostate | Tumor | histone lysine methylation | 34/3246 | 115/18723 | 8.31e-04 | 5.60e-03 | 34 |
GO:01201623 | Prostate | Tumor | positive regulation of cold-induced thermogenesis | 28/3246 | 97/18723 | 3.35e-03 | 1.74e-02 | 28 |
GO:19908453 | Prostate | Tumor | adaptive thermogenesis | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
GO:00016593 | Prostate | Tumor | temperature homeostasis | 44/3246 | 174/18723 | 5.04e-03 | 2.45e-02 | 44 |
GO:00616471 | Prostate | Tumor | histone H3-K9 modification | 16/3246 | 48/18723 | 5.39e-03 | 2.57e-02 | 16 |
GO:01061064 | Prostate | Tumor | cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
GO:01201614 | Prostate | Tumor | regulation of cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
GO:001802212 | Prostate | Tumor | peptidyl-lysine methylation | 34/3246 | 131/18723 | 8.36e-03 | 3.65e-02 | 34 |
GO:00165709 | Skin | AK | histone modification | 84/1910 | 463/18723 | 1.10e-07 | 4.95e-06 | 84 |
GO:000632518 | Skin | AK | chromatin organization | 73/1910 | 409/18723 | 1.40e-06 | 4.26e-05 | 73 |
GO:00182058 | Skin | AK | peptidyl-lysine modification | 66/1910 | 376/18723 | 7.80e-06 | 1.72e-04 | 66 |
GO:00064799 | Skin | AK | protein methylation | 38/1910 | 181/18723 | 1.21e-05 | 2.46e-04 | 38 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa042112 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa003102 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa042113 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa003103 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa003104 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa042114 | Colorectum | FAP | Longevity regulating pathway | 27/1404 | 89/8465 | 8.82e-04 | 5.20e-03 | 3.16e-03 | 27 |
hsa003105 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa042115 | Colorectum | FAP | Longevity regulating pathway | 27/1404 | 89/8465 | 8.82e-04 | 5.20e-03 | 3.16e-03 | 27 |
hsa003106 | Colorectum | CRC | Lysine degradation | 18/1091 | 63/8465 | 7.21e-04 | 6.34e-03 | 4.30e-03 | 18 |
hsa042116 | Colorectum | CRC | Longevity regulating pathway | 20/1091 | 89/8465 | 8.36e-03 | 3.93e-02 | 2.66e-02 | 20 |
hsa003107 | Colorectum | CRC | Lysine degradation | 18/1091 | 63/8465 | 7.21e-04 | 6.34e-03 | 4.30e-03 | 18 |
hsa042117 | Colorectum | CRC | Longevity regulating pathway | 20/1091 | 89/8465 | 8.36e-03 | 3.93e-02 | 2.66e-02 | 20 |
hsa0421114 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0031010 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0421115 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0031013 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EHMT1 | SNV | Missense_Mutation | | c.2330N>G | p.Leu777Arg | p.L777R | Q9H9B1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
EHMT1 | SNV | Missense_Mutation | novel | c.3146N>T | p.Pro1049Leu | p.P1049L | Q9H9B1 | protein_coding | deleterious(0.03) | possibly_damaging(0.868) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EHMT1 | SNV | Missense_Mutation | novel | c.848C>T | p.Ala283Val | p.A283V | Q9H9B1 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.99) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
EHMT1 | SNV | Missense_Mutation | | c.3092G>T | p.Ser1031Ile | p.S1031I | Q9H9B1 | protein_coding | deleterious(0.01) | possibly_damaging(0.799) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EHMT1 | SNV | Missense_Mutation | novel | c.877N>G | p.Met293Val | p.M293V | Q9H9B1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.867) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EHMT1 | SNV | Missense_Mutation | novel | c.769C>A | p.His257Asn | p.H257N | Q9H9B1 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.476) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
EHMT1 | SNV | Missense_Mutation | novel | c.3704G>C | p.Gly1235Ala | p.G1235A | Q9H9B1 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
EHMT1 | SNV | Missense_Mutation | rs761131393 | c.838N>T | p.Val280Phe | p.V280F | Q9H9B1 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.564) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
EHMT1 | SNV | Missense_Mutation | | c.1037N>C | p.Met346Thr | p.M346T | Q9H9B1 | protein_coding | tolerated_low_confidence(0.11) | benign(0.022) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EHMT1 | SNV | Missense_Mutation | rs761131393 | c.838G>T | p.Val280Phe | p.V280F | Q9H9B1 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.564) | TCGA-C8-A137-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |