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Gene: DUSP22 |
Gene summary for DUSP22 |
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Gene information | Species | Human | Gene symbol | DUSP22 | Gene ID | 56940 |
Gene name | dual specificity phosphatase 22 | |
Gene Alias | JKAP | |
Cytomap | 6p25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NRW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56940 | DUSP22 | LZE8T | Human | Esophagus | ESCC | 1.31e-02 | 1.67e-01 | 0.067 |
56940 | DUSP22 | LZE20T | Human | Esophagus | ESCC | 4.56e-05 | 3.24e-01 | 0.0662 |
56940 | DUSP22 | LZE24T | Human | Esophagus | ESCC | 4.71e-12 | 4.18e-01 | 0.0596 |
56940 | DUSP22 | LZE6T | Human | Esophagus | ESCC | 4.32e-05 | 2.60e-01 | 0.0845 |
56940 | DUSP22 | P1T-E | Human | Esophagus | ESCC | 1.62e-05 | 4.44e-01 | 0.0875 |
56940 | DUSP22 | P2T-E | Human | Esophagus | ESCC | 6.13e-22 | 4.13e-01 | 0.1177 |
56940 | DUSP22 | P4T-E | Human | Esophagus | ESCC | 3.15e-17 | 4.58e-01 | 0.1323 |
56940 | DUSP22 | P5T-E | Human | Esophagus | ESCC | 3.63e-08 | 1.86e-01 | 0.1327 |
56940 | DUSP22 | P8T-E | Human | Esophagus | ESCC | 1.59e-12 | 2.21e-01 | 0.0889 |
56940 | DUSP22 | P9T-E | Human | Esophagus | ESCC | 8.65e-03 | 1.36e-01 | 0.1131 |
56940 | DUSP22 | P10T-E | Human | Esophagus | ESCC | 2.72e-05 | 1.44e-02 | 0.116 |
56940 | DUSP22 | P11T-E | Human | Esophagus | ESCC | 4.74e-06 | 6.29e-01 | 0.1426 |
56940 | DUSP22 | P12T-E | Human | Esophagus | ESCC | 1.77e-09 | 1.78e-01 | 0.1122 |
56940 | DUSP22 | P15T-E | Human | Esophagus | ESCC | 9.22e-14 | 2.65e-01 | 0.1149 |
56940 | DUSP22 | P16T-E | Human | Esophagus | ESCC | 2.46e-15 | 2.09e-01 | 0.1153 |
56940 | DUSP22 | P17T-E | Human | Esophagus | ESCC | 4.15e-07 | 5.56e-01 | 0.1278 |
56940 | DUSP22 | P20T-E | Human | Esophagus | ESCC | 2.27e-12 | 2.97e-01 | 0.1124 |
56940 | DUSP22 | P21T-E | Human | Esophagus | ESCC | 3.85e-35 | 6.09e-01 | 0.1617 |
56940 | DUSP22 | P22T-E | Human | Esophagus | ESCC | 3.80e-14 | 2.06e-01 | 0.1236 |
56940 | DUSP22 | P23T-E | Human | Esophagus | ESCC | 2.23e-12 | 3.96e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000725423 | Skin | cSCC | JNK cascade | 60/4864 | 167/18723 | 2.77e-03 | 1.56e-02 | 60 |
GO:0033673110 | Skin | cSCC | negative regulation of kinase activity | 81/4864 | 237/18723 | 2.95e-03 | 1.64e-02 | 81 |
GO:000717917 | Skin | cSCC | transforming growth factor beta receptor signaling pathway | 69/4864 | 198/18723 | 3.39e-03 | 1.84e-02 | 69 |
GO:004632823 | Skin | cSCC | regulation of JNK cascade | 49/4864 | 133/18723 | 3.64e-03 | 1.95e-02 | 49 |
GO:00507323 | Skin | cSCC | negative regulation of peptidyl-tyrosine phosphorylation | 25/4864 | 59/18723 | 4.46e-03 | 2.29e-02 | 25 |
GO:000716224 | Skin | cSCC | negative regulation of cell adhesion | 98/4864 | 303/18723 | 7.45e-03 | 3.50e-02 | 98 |
GO:001081221 | Skin | cSCC | negative regulation of cell-substrate adhesion | 27/4864 | 68/18723 | 9.07e-03 | 4.16e-02 | 27 |
GO:00019531 | Skin | cSCC | negative regulation of cell-matrix adhesion | 18/4864 | 41/18723 | 9.64e-03 | 4.31e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP22 | SNV | Missense_Mutation | novel | c.272N>C | p.Gly91Ala | p.G91A | Q9NRW4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DUSP22 | SNV | Missense_Mutation | novel | c.568N>A | p.Phe190Ile | p.F190I | Q9NRW4 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR |
DUSP22 | SNV | Missense_Mutation | c.212N>A | p.Ile71Asn | p.I71N | Q9NRW4 | protein_coding | tolerated(0.2) | probably_damaging(0.948) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
DUSP22 | SNV | Missense_Mutation | rs772626114 | c.529N>T | p.Arg177Cys | p.R177C | Q9NRW4 | protein_coding | deleterious(0.01) | possibly_damaging(0.491) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD |
DUSP22 | insertion | Nonsense_Mutation | novel | c.432_433insTCTAGGAATTAATACTTCATA | p.His144_Gln145insSerArgAsnTerTyrPheIle | p.H144_Q145insSRN*YFI | Q9NRW4 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DUSP22 | SNV | Missense_Mutation | rs768192099 | c.301N>A | p.Ala101Thr | p.A101T | Q9NRW4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DUSP22 | SNV | Missense_Mutation | c.563N>T | p.Ser188Ile | p.S188I | Q9NRW4 | protein_coding | tolerated(0.18) | benign(0.006) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
DUSP22 | SNV | Missense_Mutation | c.149N>G | p.Tyr50Cys | p.Y50C | Q9NRW4 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DUSP22 | SNV | Missense_Mutation | c.82A>G | p.Lys28Glu | p.K28E | Q9NRW4 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DUSP22 | SNV | Missense_Mutation | rs772626114 | c.529N>T | p.Arg177Cys | p.R177C | Q9NRW4 | protein_coding | deleterious(0.01) | possibly_damaging(0.491) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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