Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DSG2

Gene summary for DSG2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DSG2

Gene ID

1829

Gene namedesmoglein 2
Gene AliasCDHF5
Cytomap18q12.1
Gene Typeprotein-coding
GO ID

GO:0001508

UniProtAcc

Q14126


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1829DSG2HTA11_1938_2000001011HumanColorectumAD1.72e-056.78e-01-0.0811
1829DSG2HTA11_78_2000001011HumanColorectumAD5.26e-077.27e-01-0.1088
1829DSG2HTA11_347_2000001011HumanColorectumAD2.12e-249.43e-01-0.1954
1829DSG2HTA11_411_2000001011HumanColorectumSER1.19e-029.98e-01-0.2602
1829DSG2HTA11_6801_2000001011HumanColorectumSER4.90e-027.10e-010.0171
1829DSG2HTA11_99999970781_79442HumanColorectumMSS1.46e-056.17e-010.294
1829DSG2HTA11_99999965104_69814HumanColorectumMSS8.26e-159.70e-010.281
1829DSG2F007HumanColorectumFAP1.23e-06-4.30e-010.1176
1829DSG2A001-C-207HumanColorectumFAP2.24e-05-2.61e-010.1278
1829DSG2A015-C-203HumanColorectumFAP8.39e-23-3.79e-01-0.1294
1829DSG2A015-C-204HumanColorectumFAP8.04e-08-2.37e-01-0.0228
1829DSG2A014-C-040HumanColorectumFAP5.29e-07-5.84e-01-0.1184
1829DSG2A002-C-201HumanColorectumFAP6.50e-15-3.12e-010.0324
1829DSG2A002-C-203HumanColorectumFAP2.83e-03-7.05e-020.2786
1829DSG2A001-C-119HumanColorectumFAP1.47e-08-4.15e-01-0.1557
1829DSG2A001-C-108HumanColorectumFAP8.08e-15-2.54e-01-0.0272
1829DSG2A002-C-205HumanColorectumFAP7.55e-21-3.80e-01-0.1236
1829DSG2A014-C-108HumanColorectumFAP4.49e-03-3.50e-01-0.124
1829DSG2A001-C-104HumanColorectumFAP2.92e-03-2.44e-010.0184
1829DSG2A015-C-005HumanColorectumFAP7.71e-04-1.75e-01-0.0336
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0003161ThyroidHTcardiac conduction system development8/127237/187232.91e-032.36e-028
GO:00032292ThyroidHTventricular cardiac muscle tissue development10/127255/187233.57e-032.73e-0210
GO:009025715ThyroidHTregulation of muscle system process29/1272252/187233.79e-032.82e-0229
GO:009890118ThyroidHTregulation of cardiac muscle cell action potential6/127227/187238.36e-034.79e-026
GO:0032970113ThyroidPTCregulation of actin filament-based process197/5968397/187238.91e-144.89e-12197
GO:0045216111ThyroidPTCcell-cell junction organization93/5968200/187231.01e-051.12e-0493
GO:0034109112ThyroidPTChomotypic cell-cell adhesion47/596890/187234.81e-054.31e-0447
GO:006053719ThyroidPTCmuscle tissue development156/5968403/187231.98e-031.06e-02156
GO:001470617ThyroidPTCstriated muscle tissue development144/5968384/187231.05e-024.22e-02144
GO:0032970210ThyroidATCregulation of actin filament-based process208/6293397/187235.82e-153.80e-13208
GO:006053724ThyroidATCmuscle tissue development181/6293403/187231.27e-061.62e-05181
GO:004521629ThyroidATCcell-cell junction organization99/6293200/187232.26e-062.68e-0599
GO:001470622ThyroidATCstriated muscle tissue development168/6293384/187231.91e-051.73e-04168
GO:003410933ThyroidATChomotypic cell-cell adhesion48/629390/187238.92e-056.59e-0448
GO:004873811ThyroidATCcardiac muscle tissue development103/6293236/187237.93e-044.37e-03103
GO:00032291ThyroidATCventricular cardiac muscle tissue development27/629355/187231.24e-024.38e-0227
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05412ColorectumFAPArrhythmogenic right ventricular cardiomyopathy23/140477/84652.58e-031.19e-027.23e-0323
hsa054121ColorectumFAPArrhythmogenic right ventricular cardiomyopathy23/140477/84652.58e-031.19e-027.23e-0323
hsa054122ColorectumCRCArrhythmogenic right ventricular cardiomyopathy18/109177/84657.90e-033.77e-022.55e-0218
hsa054123ColorectumCRCArrhythmogenic right ventricular cardiomyopathy18/109177/84657.90e-033.77e-022.55e-0218
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
DSC2DSG2DSC2_DSG2DESMOSOMEBreastDCIS
DSC2DSG2DSC2_DSG2DESMOSOMEBreastHealthy
DSG2DSC3DSG2_DSC3DESMOSOMEBreastIDC
DSC2DSG2DSC2_DSG2DESMOSOMEBreastPrecancer
DSC2DSG2DSC2_DSG2DESMOSOMECervixCC
DSG2DSC3DSG2_DSC3DESMOSOMECervixCC
DSC2DSG2DSC2_DSG2DESMOSOMECervixPrecancer
DSC2DSG2DSC2_DSG2DESMOSOMECRCAD
DSC2DSG2DSC2_DSG2DESMOSOMECRCADJ
DSC2DSG2DSC2_DSG2DESMOSOMECRCFAP
DSC2DSG2DSC2_DSG2DESMOSOMECRCHealthy
DSC2DSG2DSC2_DSG2DESMOSOMECRCMSI-H
DSC2DSG2DSC2_DSG2DESMOSOMECRCMSS
DSC2DSG2DSC2_DSG2DESMOSOMECRCSER
DSC2DSG2DSC2_DSG2DESMOSOMEEsophagusADJ
DSG2DSC3DSG2_DSC3DESMOSOMEEsophagusADJ
DSC2DSG2DSC2_DSG2DESMOSOMEEsophagusESCC
DSG2DSC3DSG2_DSC3DESMOSOMEEsophagusESCC
DSC1DSG2DSC1_DSG2DESMOSOMEHNSCCOSCC
DSC2DSG2DSC2_DSG2DESMOSOMEHNSCCOSCC
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DSG2SNVMissense_Mutationnovelc.2128N>Cp.Glu710Glnp.E710QQ14126protein_codingtolerated(0.44)benign(0.153)TCGA-BH-A2L8-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
DSG2SNVMissense_Mutationrs748445394c.219N>Gp.Ile73Metp.I73MQ14126protein_codingdeleterious(0.01)benign(0.254)TCGA-EW-A1OY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
DSG2insertionIn_Frame_Insnovelc.2963_2964insATTp.Thr988_Glu989insPhep.T988_E989insFQ14126protein_codingTCGA-A7-A26I-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
DSG2insertionFrame_Shift_Insnovelc.759_760insGCCTGGGCAACAGAGCAAGACTCCATATCCAAAAAAAAGAAAAGp.Lys254AlafsTer33p.K254Afs*33Q14126protein_codingTCGA-A8-A095-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
DSG2insertionFrame_Shift_Insnovelc.617_618insCAAGAAATATATTAAATTTTTTTGTTTGTp.Tyr207LysfsTer17p.Y207Kfs*17Q14126protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DSG2deletionFrame_Shift_Delnovelc.654delNp.Glu219ArgfsTer19p.E219Rfs*19Q14126protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
DSG2SNVMissense_Mutationrs751064437c.2915N>Tp.Ser972Phep.S972FQ14126protein_codingdeleterious(0.01)possibly_damaging(0.87)TCGA-JX-A3Q0-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
DSG2SNVMissense_Mutationc.1045G>Cp.Asp349Hisp.D349HQ14126protein_codingdeleterious(0.01)possibly_damaging(0.897)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DSG2SNVMissense_Mutationnovelc.2635G>Cp.Glu879Glnp.E879QQ14126protein_codingtolerated(0.09)possibly_damaging(0.454)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DSG2SNVMissense_Mutationnovelc.134N>Cp.Val45Alap.V45AQ14126protein_codingdeleterious(0.02)benign(0.006)TCGA-VS-A9UD-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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