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Gene: DERA |
Gene summary for DERA |
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Gene information | Species | Human | Gene symbol | DERA | Gene ID | 51071 |
Gene name | deoxyribose-phosphate aldolase | |
Gene Alias | CGI-26 | |
Cytomap | 12p12.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | E9PPM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51071 | DERA | CCI_1 | Human | Cervix | CC | 2.35e-02 | 5.71e-01 | 0.528 |
51071 | DERA | CCI_2 | Human | Cervix | CC | 4.67e-04 | 6.65e-01 | 0.5249 |
51071 | DERA | CCI_3 | Human | Cervix | CC | 8.73e-08 | 7.48e-01 | 0.516 |
51071 | DERA | sample3 | Human | Cervix | CC | 4.94e-04 | 2.10e-01 | 0.1387 |
51071 | DERA | LZE2T | Human | Esophagus | ESCC | 1.44e-03 | 5.40e-01 | 0.082 |
51071 | DERA | LZE3D | Human | Esophagus | HGIN | 6.52e-03 | 5.66e-01 | 0.0668 |
51071 | DERA | LZE4T | Human | Esophagus | ESCC | 5.76e-11 | 3.03e-01 | 0.0811 |
51071 | DERA | LZE5T | Human | Esophagus | ESCC | 1.31e-05 | 4.02e-01 | 0.0514 |
51071 | DERA | LZE7T | Human | Esophagus | ESCC | 5.73e-07 | 6.37e-01 | 0.0667 |
51071 | DERA | LZE8T | Human | Esophagus | ESCC | 4.91e-23 | 7.27e-01 | 0.067 |
51071 | DERA | LZE20T | Human | Esophagus | ESCC | 4.12e-09 | 3.06e-01 | 0.0662 |
51071 | DERA | LZE22D1 | Human | Esophagus | HGIN | 1.25e-03 | 1.44e-01 | 0.0595 |
51071 | DERA | LZE22T | Human | Esophagus | ESCC | 2.40e-02 | 4.26e-01 | 0.068 |
51071 | DERA | LZE24T | Human | Esophagus | ESCC | 2.65e-20 | 5.32e-01 | 0.0596 |
51071 | DERA | LZE21T | Human | Esophagus | ESCC | 2.19e-06 | 5.62e-01 | 0.0655 |
51071 | DERA | LZE6T | Human | Esophagus | ESCC | 1.64e-08 | 2.84e-01 | 0.0845 |
51071 | DERA | P2T-E | Human | Esophagus | ESCC | 1.86e-41 | 8.39e-01 | 0.1177 |
51071 | DERA | P4T-E | Human | Esophagus | ESCC | 3.05e-41 | 1.09e+00 | 0.1323 |
51071 | DERA | P5T-E | Human | Esophagus | ESCC | 6.42e-25 | 5.95e-01 | 0.1327 |
51071 | DERA | P8T-E | Human | Esophagus | ESCC | 1.85e-36 | 6.69e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
GO:000911725 | Thyroid | PTC | nucleotide metabolic process | 202/5968 | 489/18723 | 5.46e-06 | 6.60e-05 | 202 |
GO:001605218 | Thyroid | PTC | carbohydrate catabolic process | 70/5968 | 154/18723 | 2.77e-04 | 1.97e-03 | 70 |
GO:00067405 | Thyroid | PTC | NADPH regeneration | 10/5968 | 16/18723 | 1.13e-02 | 4.49e-02 | 10 |
GO:000609134 | Thyroid | ATC | generation of precursor metabolites and energy | 256/6293 | 490/18723 | 6.55e-18 | 7.69e-16 | 256 |
GO:003465525 | Thyroid | ATC | nucleobase-containing compound catabolic process | 217/6293 | 407/18723 | 1.20e-16 | 1.04e-14 | 217 |
GO:004670024 | Thyroid | ATC | heterocycle catabolic process | 228/6293 | 445/18723 | 7.26e-15 | 4.50e-13 | 228 |
GO:004427025 | Thyroid | ATC | cellular nitrogen compound catabolic process | 229/6293 | 451/18723 | 2.25e-14 | 1.27e-12 | 229 |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
GO:190136124 | Thyroid | ATC | organic cyclic compound catabolic process | 238/6293 | 495/18723 | 1.12e-11 | 4.12e-10 | 238 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:001605224 | Thyroid | ATC | carbohydrate catabolic process | 71/6293 | 154/18723 | 8.33e-04 | 4.57e-03 | 71 |
GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00030 | Liver | Cirrhotic | Pentose phosphate pathway | 16/2530 | 30/8465 | 6.04e-03 | 2.12e-02 | 1.30e-02 | 16 |
hsa000301 | Liver | Cirrhotic | Pentose phosphate pathway | 16/2530 | 30/8465 | 6.04e-03 | 2.12e-02 | 1.30e-02 | 16 |
hsa000302 | Liver | HCC | Pentose phosphate pathway | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa000303 | Liver | HCC | Pentose phosphate pathway | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DERA | SNV | Missense_Mutation | rs775272940 | c.416N>A | p.Arg139Gln | p.R139Q | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DERA | SNV | Missense_Mutation | rs778363116 | c.536G>A | p.Arg179His | p.R179H | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
DERA | SNV | Missense_Mutation | rs760703237 | c.712N>T | p.Arg238Trp | p.R238W | Q9Y315 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DERA | SNV | Missense_Mutation | c.634G>A | p.Ala212Thr | p.A212T | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
DERA | SNV | Missense_Mutation | c.766G>A | p.Ala256Thr | p.A256T | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DERA | SNV | Missense_Mutation | c.860N>A | p.Arg287Gln | p.R287Q | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DERA | SNV | Missense_Mutation | c.860G>A | p.Arg287Gln | p.R287Q | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
DERA | SNV | Missense_Mutation | novel | c.893N>G | p.Glu298Gly | p.E298G | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DERA | SNV | Missense_Mutation | c.457G>A | p.Glu153Lys | p.E153K | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DERA | SNV | Missense_Mutation | novel | c.292G>A | p.Ala98Thr | p.A98T | Q9Y315 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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