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Gene: CAPZA1 |
Gene summary for CAPZA1 |
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Gene information | Species | Human | Gene symbol | CAPZA1 | Gene ID | 829 |
Gene name | capping actin protein of muscle Z-line subunit alpha 1 | |
Gene Alias | CAPPA1 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A0A024R0E5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
829 | CAPZA1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.07e-04 | -3.74e-01 | 0.0155 |
829 | CAPZA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-06 | 4.46e-01 | -0.1954 |
829 | CAPZA1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.17e-03 | 5.66e-01 | 0.294 |
829 | CAPZA1 | A002-C-010 | Human | Colorectum | FAP | 9.33e-05 | -1.56e-01 | 0.242 |
829 | CAPZA1 | A015-C-203 | Human | Colorectum | FAP | 2.50e-24 | -3.83e-01 | -0.1294 |
829 | CAPZA1 | A015-C-204 | Human | Colorectum | FAP | 3.95e-04 | -2.56e-01 | -0.0228 |
829 | CAPZA1 | A014-C-040 | Human | Colorectum | FAP | 1.60e-03 | -4.81e-01 | -0.1184 |
829 | CAPZA1 | A002-C-201 | Human | Colorectum | FAP | 9.48e-09 | -3.43e-01 | 0.0324 |
829 | CAPZA1 | A002-C-203 | Human | Colorectum | FAP | 5.34e-06 | -2.04e-01 | 0.2786 |
829 | CAPZA1 | A001-C-119 | Human | Colorectum | FAP | 1.77e-06 | -4.40e-01 | -0.1557 |
829 | CAPZA1 | A001-C-108 | Human | Colorectum | FAP | 5.85e-20 | -3.00e-01 | -0.0272 |
829 | CAPZA1 | A002-C-205 | Human | Colorectum | FAP | 2.62e-14 | -3.93e-01 | -0.1236 |
829 | CAPZA1 | A001-C-104 | Human | Colorectum | FAP | 4.85e-03 | -2.08e-01 | 0.0184 |
829 | CAPZA1 | A015-C-005 | Human | Colorectum | FAP | 1.75e-02 | -2.94e-01 | -0.0336 |
829 | CAPZA1 | A015-C-006 | Human | Colorectum | FAP | 3.43e-11 | -4.60e-01 | -0.0994 |
829 | CAPZA1 | A015-C-106 | Human | Colorectum | FAP | 2.32e-16 | -3.28e-01 | -0.0511 |
829 | CAPZA1 | A002-C-114 | Human | Colorectum | FAP | 1.58e-12 | -4.24e-01 | -0.1561 |
829 | CAPZA1 | A015-C-104 | Human | Colorectum | FAP | 4.29e-26 | -4.17e-01 | -0.1899 |
829 | CAPZA1 | A001-C-014 | Human | Colorectum | FAP | 9.99e-15 | -2.69e-01 | 0.0135 |
829 | CAPZA1 | A002-C-016 | Human | Colorectum | FAP | 5.55e-20 | -3.67e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003295612 | Liver | Cirrhotic | regulation of actin cytoskeleton organization | 136/4634 | 358/18723 | 1.47e-08 | 5.49e-07 | 136 |
GO:005125812 | Liver | Cirrhotic | protein polymerization | 116/4634 | 297/18723 | 2.87e-08 | 9.78e-07 | 116 |
GO:00313337 | Liver | Cirrhotic | negative regulation of protein-containing complex assembly | 64/4634 | 141/18723 | 7.08e-08 | 2.14e-06 | 64 |
GO:011005312 | Liver | Cirrhotic | regulation of actin filament organization | 108/4634 | 278/18723 | 1.17e-07 | 3.32e-06 | 108 |
GO:003227112 | Liver | Cirrhotic | regulation of protein polymerization | 92/4634 | 233/18723 | 4.25e-07 | 9.86e-06 | 92 |
GO:000815412 | Liver | Cirrhotic | actin polymerization or depolymerization | 86/4634 | 218/18723 | 1.04e-06 | 2.13e-05 | 86 |
GO:003004112 | Liver | Cirrhotic | actin filament polymerization | 77/4634 | 191/18723 | 1.41e-06 | 2.79e-05 | 77 |
GO:003253512 | Liver | Cirrhotic | regulation of cellular component size | 135/4634 | 383/18723 | 2.32e-06 | 4.26e-05 | 135 |
GO:00106397 | Liver | Cirrhotic | negative regulation of organelle organization | 124/4634 | 348/18723 | 3.20e-06 | 5.60e-05 | 124 |
GO:003083312 | Liver | Cirrhotic | regulation of actin filament polymerization | 69/4634 | 172/18723 | 5.92e-06 | 9.65e-05 | 69 |
GO:00080647 | Liver | Cirrhotic | regulation of actin polymerization or depolymerization | 74/4634 | 188/18723 | 6.26e-06 | 9.92e-05 | 74 |
GO:00308327 | Liver | Cirrhotic | regulation of actin filament length | 74/4634 | 189/18723 | 7.83e-06 | 1.18e-04 | 74 |
GO:00329846 | Liver | Cirrhotic | protein-containing complex disassembly | 82/4634 | 224/18723 | 4.78e-05 | 5.54e-04 | 82 |
GO:19029046 | Liver | Cirrhotic | negative regulation of supramolecular fiber organization | 63/4634 | 167/18723 | 1.29e-04 | 1.26e-03 | 63 |
GO:00322727 | Liver | Cirrhotic | negative regulation of protein polymerization | 35/4634 | 80/18723 | 1.54e-04 | 1.47e-03 | 35 |
GO:00308376 | Liver | Cirrhotic | negative regulation of actin filament polymerization | 29/4634 | 65/18723 | 3.68e-04 | 3.09e-03 | 29 |
GO:00510166 | Liver | Cirrhotic | barbed-end actin filament capping | 14/4634 | 26/18723 | 1.37e-03 | 9.14e-03 | 14 |
GO:00300426 | Liver | Cirrhotic | actin filament depolymerization | 24/4634 | 59/18723 | 5.06e-03 | 2.62e-02 | 24 |
GO:00516935 | Liver | Cirrhotic | actin filament capping | 18/4634 | 41/18723 | 5.65e-03 | 2.85e-02 | 18 |
GO:00308346 | Liver | Cirrhotic | regulation of actin filament depolymerization | 22/4634 | 54/18723 | 6.96e-03 | 3.39e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414414 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
hsa0414415 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPZA1 | SNV | Missense_Mutation | novel | c.86T>G | p.Phe29Cys | p.F29C | P52907 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CAPZA1 | SNV | Missense_Mutation | c.847N>G | p.Met283Val | p.M283V | P52907 | protein_coding | deleterious(0.02) | possibly_damaging(0.678) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPZA1 | SNV | Missense_Mutation | novel | c.157G>A | p.Ala53Thr | p.A53T | P52907 | protein_coding | deleterious(0.04) | possibly_damaging(0.868) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CAPZA1 | SNV | Missense_Mutation | c.776N>A | p.Arg259His | p.R259H | P52907 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CAPZA1 | SNV | Missense_Mutation | rs773856348 | c.808G>A | p.Asp270Asn | p.D270N | P52907 | protein_coding | tolerated(0.08) | probably_damaging(0.986) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
CAPZA1 | SNV | Missense_Mutation | rs769657219 | c.797G>A | p.Arg266His | p.R266H | P52907 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
CAPZA1 | SNV | Missense_Mutation | c.260N>G | p.Phe87Cys | p.F87C | P52907 | protein_coding | deleterious(0) | benign(0.076) | TCGA-AG-3909-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
CAPZA1 | SNV | Missense_Mutation | novel | c.94G>T | p.Val32Leu | p.V32L | P52907 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAPZA1 | SNV | Missense_Mutation | novel | c.767N>C | p.Lys256Thr | p.K256T | P52907 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPZA1 | SNV | Missense_Mutation | novel | c.703G>A | p.Ala235Thr | p.A235T | P52907 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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