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Gene: BOP1 |
Gene summary for BOP1 |
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Gene information | Species | Human | Gene symbol | BOP1 | Gene ID | 23246 |
Gene name | BOP1 ribosomal biogenesis factor | |
Gene Alias | BOP1 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000027 | UniProtAcc | Q14137 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23246 | BOP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.37e-08 | 3.24e-01 | -0.059 |
23246 | BOP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.62e-05 | 2.89e-01 | 0.096 |
23246 | BOP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.98e-08 | 2.81e-01 | 0.0674 |
23246 | BOP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.23e-02 | 3.02e-01 | 0.0588 |
23246 | BOP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.64e-37 | 8.95e-01 | 0.3859 |
23246 | BOP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.27e-15 | 4.71e-01 | 0.3005 |
23246 | BOP1 | CRC-3-11773 | Human | Colorectum | CRC | 2.12e-14 | 5.85e-01 | 0.2564 |
23246 | BOP1 | LZE20T | Human | Esophagus | ESCC | 2.13e-04 | 2.29e-01 | 0.0662 |
23246 | BOP1 | LZE22T | Human | Esophagus | ESCC | 1.57e-06 | 4.58e-01 | 0.068 |
23246 | BOP1 | LZE24T | Human | Esophagus | ESCC | 7.15e-21 | 5.66e-01 | 0.0596 |
23246 | BOP1 | LZE21T | Human | Esophagus | ESCC | 9.05e-05 | 4.96e-01 | 0.0655 |
23246 | BOP1 | P1T-E | Human | Esophagus | ESCC | 8.48e-05 | 2.99e-01 | 0.0875 |
23246 | BOP1 | P2T-E | Human | Esophagus | ESCC | 3.48e-27 | 5.64e-01 | 0.1177 |
23246 | BOP1 | P4T-E | Human | Esophagus | ESCC | 6.35e-23 | 5.97e-01 | 0.1323 |
23246 | BOP1 | P5T-E | Human | Esophagus | ESCC | 7.53e-37 | 7.40e-01 | 0.1327 |
23246 | BOP1 | P8T-E | Human | Esophagus | ESCC | 7.24e-10 | 2.25e-01 | 0.0889 |
23246 | BOP1 | P9T-E | Human | Esophagus | ESCC | 4.34e-24 | 6.70e-01 | 0.1131 |
23246 | BOP1 | P10T-E | Human | Esophagus | ESCC | 1.53e-22 | 4.07e-01 | 0.116 |
23246 | BOP1 | P11T-E | Human | Esophagus | ESCC | 3.55e-09 | 5.06e-01 | 0.1426 |
23246 | BOP1 | P12T-E | Human | Esophagus | ESCC | 1.47e-43 | 9.53e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000047811 | Thyroid | ATC | endonucleolytic cleavage involved in rRNA processing | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
GO:000047911 | Thyroid | ATC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
GO:000046611 | Thyroid | ATC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/6293 | 24/18723 | 3.52e-03 | 1.56e-02 | 15 |
GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BOP1 | SNV | Missense_Mutation | novel | c.2015N>C | p.His672Pro | p.H672P | Q14137 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
BOP1 | SNV | Missense_Mutation | rs782512248 | c.226N>A | p.Glu76Lys | p.E76K | Q14137 | protein_coding | tolerated(0.33) | benign(0.019) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD |
BOP1 | SNV | Missense_Mutation | novel | c.2015N>C | p.His672Pro | p.H672P | Q14137 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A1AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
BOP1 | SNV | Missense_Mutation | novel | c.760N>A | p.Glu254Lys | p.E254K | Q14137 | protein_coding | tolerated(0.75) | benign(0.012) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
BOP1 | insertion | Frame_Shift_Ins | novel | c.445_446insC | p.His149ProfsTer20 | p.H149Pfs*20 | Q14137 | protein_coding | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BOP1 | insertion | In_Frame_Ins | novel | c.146_147insAGATTATGGACAACTACGTTACCCCTTCTTGAGTTT | p.Asp49delinsGluAspTyrGlyGlnLeuArgTyrProPheLeuSerPhe | p.D49delinsEDYGQLRYPFLSF | Q14137 | protein_coding | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
BOP1 | SNV | Missense_Mutation | novel | c.473N>A | p.Arg158His | p.R158H | Q14137 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BOP1 | SNV | Missense_Mutation | novel | c.811N>T | p.Arg271Cys | p.R271C | Q14137 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BOP1 | SNV | Missense_Mutation | novel | c.1733G>T | p.Ser578Ile | p.S578I | Q14137 | protein_coding | deleterious(0.03) | benign(0.325) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BOP1 | SNV | Missense_Mutation | novel | c.1399G>A | p.Ala467Thr | p.A467T | Q14137 | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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