Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: BCAS3

Gene summary for BCAS3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

BCAS3

Gene ID

54828

Gene nameBCAS3 microtubule associated cell migration factor
Gene AliasGAOB1
Cytomap17q23.2
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

Q9H6U6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54828BCAS3CCI_1HumanCervixCC1.48e-101.07e+000.528
54828BCAS3CCI_2HumanCervixCC3.64e-024.49e-010.5249
54828BCAS3CCI_3HumanCervixCC9.94e-291.58e+000.516
54828BCAS3CCII_1HumanCervixCC1.27e-165.97e-010.3249
54828BCAS3HTA11_99999970781_79442HumanColorectumMSS2.30e-05-3.75e-010.294
54828BCAS3HTA11_99999965104_69814HumanColorectumMSS2.90e-066.97e-010.281
54828BCAS3A015-C-203HumanColorectumFAP5.74e-20-2.60e-01-0.1294
54828BCAS3A002-C-201HumanColorectumFAP7.84e-06-1.01e-010.0324
54828BCAS3A001-C-119HumanColorectumFAP8.87e-037.74e-05-0.1557
54828BCAS3A001-C-108HumanColorectumFAP1.11e-061.60e-02-0.0272
54828BCAS3A002-C-021HumanColorectumFAP1.30e-043.39e-010.1171
54828BCAS3A002-C-205HumanColorectumFAP1.24e-19-3.45e-01-0.1236
54828BCAS3A015-C-006HumanColorectumFAP5.16e-15-5.11e-01-0.0994
54828BCAS3A015-C-106HumanColorectumFAP2.50e-049.28e-03-0.0511
54828BCAS3A002-C-114HumanColorectumFAP9.26e-17-2.80e-01-0.1561
54828BCAS3A015-C-104HumanColorectumFAP6.25e-22-2.60e-01-0.1899
54828BCAS3A001-C-014HumanColorectumFAP1.05e-05-1.35e-020.0135
54828BCAS3A002-C-016HumanColorectumFAP5.25e-16-1.83e-010.0521
54828BCAS3A015-C-002HumanColorectumFAP7.09e-10-3.31e-01-0.0763
54828BCAS3A001-C-203HumanColorectumFAP1.66e-04-3.66e-03-0.0481
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00903168EndometriumAEHpositive regulation of intracellular protein transport38/2100160/187235.22e-061.33e-0438
GO:00430878EndometriumAEHregulation of GTPase activity66/2100348/187231.26e-052.77e-0466
GO:005149514EndometriumAEHpositive regulation of cytoskeleton organization47/2100226/187232.00e-054.05e-0447
GO:00435428EndometriumAEHendothelial cell migration55/2100279/187232.11e-054.15e-0455
GO:00105955EndometriumAEHpositive regulation of endothelial cell migration32/2100133/187232.12e-054.15e-0432
GO:00105945EndometriumAEHregulation of endothelial cell migration47/2100232/187234.02e-056.91e-0447
GO:00328787EndometriumAEHregulation of establishment or maintenance of cell polarity10/210025/187232.05e-042.54e-0310
GO:00435477EndometriumAEHpositive regulation of GTPase activity48/2100255/187232.18e-042.67e-0348
GO:005134610EndometriumAEHnegative regulation of hydrolase activity65/2100379/187233.18e-043.57e-0365
GO:003166716EndometriumAEHresponse to nutrient levels78/2100474/187233.26e-043.64e-0378
GO:20001148EndometriumAEHregulation of establishment of cell polarity9/210022/187233.51e-043.84e-039
GO:00313468EndometriumAEHpositive regulation of cell projection organization61/2100353/187233.91e-044.20e-0361
GO:00070305EndometriumAEHGolgi organization32/2100157/187235.73e-045.69e-0332
GO:19018887EndometriumAEHregulation of cell junction assembly39/2100204/187235.94e-045.86e-0339
GO:00425949EndometriumAEHresponse to starvation36/2100197/187232.15e-031.65e-0236
GO:01200329EndometriumAEHregulation of plasma membrane bounded cell projection assembly34/2100186/187232.79e-032.01e-0234
GO:20002494EndometriumAEHregulation of actin cytoskeleton reorganization11/210039/187232.92e-032.08e-0211
GO:00604918EndometriumAEHregulation of cell projection assembly34/2100188/187233.33e-032.32e-0234
GO:00071627EndometriumAEHnegative regulation of cell adhesion49/2100303/187235.43e-033.37e-0249
GO:00351488EndometriumAEHtube formation27/2100148/187237.34e-034.18e-0227
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
BCAS3SNVMissense_Mutationnovelc.410N>Gp.Gln137Argp.Q137RQ9H6U6protein_codingtolerated(0.27)benign(0.093)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
BCAS3SNVMissense_Mutationrs755073133c.68N>Ap.Arg23Hisp.R23HQ9H6U6protein_codingdeleterious(0.04)probably_damaging(0.937)TCGA-AO-A0J2-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
BCAS3SNVMissense_Mutationc.2038N>Ap.Asp680Asnp.D680NQ9H6U6protein_codingtolerated(0.07)benign(0.073)TCGA-BH-A0W7-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
BCAS3SNVMissense_Mutationnovelc.1331N>Cp.Arg444Prop.R444PQ9H6U6protein_codingdeleterious(0)possibly_damaging(0.875)TCGA-HN-A2OB-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilPD
BCAS3insertionFrame_Shift_Insnovelc.2016_2017insTGGAATCATATAATATGTGACCTTTTGTGTCTGGp.His673TrpfsTer52p.H673Wfs*52Q9H6U6protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
BCAS3SNVMissense_Mutationnovelc.2335N>Ap.Asp779Asnp.D779NQ9H6U6protein_codingtolerated(0.09)possibly_damaging(0.642)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
BCAS3SNVMissense_Mutationrs759264893c.2318N>Tp.Thr773Metp.T773MQ9H6U6protein_codingdeleterious(0.02)benign(0.401)TCGA-C5-A1BE-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
BCAS3SNVMissense_Mutationnovelc.2158G>Ap.Glu720Lysp.E720KQ9H6U6protein_codingdeleterious(0.01)possibly_damaging(0.879)TCGA-VS-A9U6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
BCAS3SNVMissense_Mutationc.1755N>Ap.Phe585Leup.F585LQ9H6U6protein_codingdeleterious(0)probably_damaging(0.987)TCGA-4N-A93T-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyxelodaSD
BCAS3SNVMissense_Mutationrs377752373c.583N>Tp.Arg195Trpp.R195WQ9H6U6protein_codingdeleterious(0)possibly_damaging(0.736)TCGA-A6-5660-01Colorectumcolon adenocarcinomaMale>=65III/IVAncillaryleucovorinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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