Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ARPC5L

Gene summary for ARPC5L

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ARPC5L

Gene ID

81873

Gene nameactin related protein 2/3 complex subunit 5 like
Gene AliasARC16-2
Cytomap9q33.3
Gene Typeprotein-coding
GO ID

GO:0006928

UniProtAcc

A0A024R897


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
81873ARPC5LHTA11_2487_2000001011HumanColorectumSER9.00e-093.67e-01-0.1808
81873ARPC5LHTA11_1938_2000001011HumanColorectumAD1.89e-053.56e-01-0.0811
81873ARPC5LHTA11_347_2000001011HumanColorectumAD4.86e-082.50e-01-0.1954
81873ARPC5LHTA11_411_2000001011HumanColorectumSER3.73e-023.72e-01-0.2602
81873ARPC5LHTA11_3361_2000001011HumanColorectumAD9.53e-063.14e-01-0.1207
81873ARPC5LHTA11_83_2000001011HumanColorectumSER4.43e-043.53e-01-0.1526
81873ARPC5LHTA11_696_2000001011HumanColorectumAD1.16e-073.02e-01-0.1464
81873ARPC5LHTA11_866_2000001011HumanColorectumAD1.05e-052.24e-01-0.1001
81873ARPC5LHTA11_1391_2000001011HumanColorectumAD3.10e-135.82e-01-0.059
81873ARPC5LHTA11_546_2000001011HumanColorectumAD4.08e-032.38e-01-0.0842
81873ARPC5LHTA11_866_3004761011HumanColorectumAD6.74e-032.06e-010.096
81873ARPC5LHTA11_10623_2000001011HumanColorectumAD3.98e-032.69e-01-0.0177
81873ARPC5LHTA11_6801_2000001011HumanColorectumSER1.26e-024.04e-010.0171
81873ARPC5LHTA11_7696_3000711011HumanColorectumAD2.35e-042.50e-010.0674
81873ARPC5LHTA11_7469_2000001011HumanColorectumAD6.10e-033.89e-01-0.0124
81873ARPC5LHTA11_99999970781_79442HumanColorectumMSS3.70e-042.33e-010.294
81873ARPC5LHTA11_99999965104_69814HumanColorectumMSS6.85e-083.81e-010.281
81873ARPC5LHTA11_99999971662_82457HumanColorectumMSS5.72e-175.39e-010.3859
81873ARPC5LHTA11_99999973899_84307HumanColorectumMSS4.62e-042.82e-010.2585
81873ARPC5LLZE2DHumanEsophagusHGIN1.50e-02-1.13e-010.0642
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051258110Oral cavityLPprotein polymerization113/4623297/187231.90e-075.92e-06113
GO:0032273110Oral cavityLPpositive regulation of protein polymerization60/4623138/187231.00e-062.50e-0560
GO:0032271110Oral cavityLPregulation of protein polymerization89/4623233/187233.00e-066.47e-0589
GO:1902905110Oral cavityLPpositive regulation of supramolecular fiber organization81/4623209/187234.30e-068.80e-0581
GO:1902903110Oral cavityLPregulation of supramolecular fiber organization131/4623383/187231.58e-052.78e-04131
GO:0032970110Oral cavityLPregulation of actin filament-based process133/4623397/187234.21e-056.09e-04133
GO:005149519Oral cavityLPpositive regulation of cytoskeleton organization82/4623226/187236.26e-058.46e-0482
GO:0032535110Oral cavityLPregulation of cellular component size128/4623383/187236.56e-058.80e-04128
GO:003083818Oral cavityLPpositive regulation of actin filament polymerization42/462399/187237.96e-051.03e-0342
GO:003083319Oral cavityLPregulation of actin filament polymerization65/4623172/187238.86e-051.11e-0365
GO:0032956110Oral cavityLPregulation of actin cytoskeleton organization120/4623358/187239.47e-051.18e-03120
GO:0007015110Oral cavityLPactin filament organization143/4623442/187231.44e-041.65e-03143
GO:000806418Oral cavityLPregulation of actin polymerization or depolymerization69/4623188/187231.55e-041.76e-0369
GO:003083217Oral cavityLPregulation of actin filament length69/4623189/187231.86e-042.05e-0369
GO:003004119Oral cavityLPactin filament polymerization69/4623191/187232.65e-042.75e-0369
GO:000815419Oral cavityLPactin polymerization or depolymerization76/4623218/187234.67e-044.42e-0376
GO:0110053110Oral cavityLPregulation of actin filament organization92/4623278/187239.25e-047.85e-0392
GO:003431413Oral cavityLPArp2/3 complex-mediated actin nucleation17/462339/187237.51e-034.15e-0217
GO:190290318ProstateBPHregulation of supramolecular fiber organization133/3107383/187232.40e-188.73e-16133
GO:000701518ProstateBPHactin filament organization147/3107442/187233.36e-181.15e-15147
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa05100ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa04530ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa04666ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa05130ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa05135ColorectumADYersinia infection58/2092137/84653.90e-064.35e-052.78e-0558
hsa04810ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051001ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa045301ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa046661ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa051301ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051351ColorectumADYersinia infection58/2092137/84653.90e-064.35e-052.78e-0558
hsa048101ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa051312ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa051002ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ARPC5LSNVMissense_Mutationc.376N>Ap.Val126Metp.V126MQ9BPX5protein_codingtolerated(0.23)benign(0.089)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ARPC5LinsertionFrame_Shift_Insrs748467178c.460_461insAp.Ter154%3Dp.*154%3DQ9BPX5protein_codingTCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
ARPC5LSNVMissense_Mutationnovelc.203C>Tp.Thr68Ilep.T68IQ9BPX5protein_codingdeleterious(0.01)possibly_damaging(0.765)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ARPC5LSNVMissense_Mutationnovelc.448A>Gp.Arg150Glyp.R150GQ9BPX5protein_codingdeleterious(0)probably_damaging(0.997)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ARPC5LdeletionFrame_Shift_Delnovelc.461delNp.Ter154%3Dp.*154%3DQ9BPX5protein_codingTCGA-EY-A215-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ARPC5LSNVMissense_Mutationnovelc.286N>Ap.Ala96Thrp.A96TQ9BPX5protein_codingtolerated(0.07)benign(0.184)TCGA-58-8388-01Lunglung squamous cell carcinomaMale<65I/IIUnknownUnknownSD
ARPC5LSNVMissense_Mutationc.390G>Cp.Trp130Cysp.W130CQ9BPX5protein_codingdeleterious(0)probably_damaging(1)TCGA-HC-8265-01Prostateprostate adenocarcinomaMale>=658UnknownUnknownSD
ARPC5LdeletionFrame_Shift_Delnovelc.461delNp.Ter154%3Dp.*154%3DQ9BPX5protein_codingTCGA-BR-4292-01Stomachstomach adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ARPC5LdeletionFrame_Shift_Delnovelc.*6delAQ9BPX5protein_codingTCGA-BR-8078-01Stomachstomach adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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