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Gene: AKR1B10 |
Gene summary for AKR1B10 |
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Gene information | Species | Human | Gene symbol | AKR1B10 | Gene ID | 57016 |
Gene name | aldo-keto reductase family 1 member B10 | |
Gene Alias | AKR1B11 | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | O60218 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57016 | AKR1B10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.50e-18 | 8.12e-01 | -0.1808 |
57016 | AKR1B10 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.44e-07 | 4.53e-01 | -0.1088 |
57016 | AKR1B10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.54e-09 | 3.43e-01 | -0.1954 |
57016 | AKR1B10 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.88e-03 | 1.23e+00 | -0.2602 |
57016 | AKR1B10 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.76e-09 | 6.12e-01 | -0.1526 |
57016 | AKR1B10 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.57e-06 | 4.32e-01 | -0.1464 |
57016 | AKR1B10 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.74e-05 | 6.51e-01 | -0.1706 |
57016 | AKR1B10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.69e-05 | 4.33e-01 | -0.2061 |
57016 | AKR1B10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.72e-02 | 5.03e-01 | 0.0171 |
57016 | AKR1B10 | LZE2D | Human | Esophagus | HGIN | 1.47e-02 | 1.10e+00 | 0.0642 |
57016 | AKR1B10 | LZE2T | Human | Esophagus | ESCC | 2.60e-15 | 2.45e+00 | 0.082 |
57016 | AKR1B10 | LZE4T | Human | Esophagus | ESCC | 5.59e-39 | 2.76e+00 | 0.0811 |
57016 | AKR1B10 | LZE7T | Human | Esophagus | ESCC | 1.51e-04 | 6.93e-01 | 0.0667 |
57016 | AKR1B10 | LZE20T | Human | Esophagus | ESCC | 1.19e-03 | 3.11e-01 | 0.0662 |
57016 | AKR1B10 | LZE22T | Human | Esophagus | ESCC | 4.41e-05 | 1.99e+00 | 0.068 |
57016 | AKR1B10 | LZE21T | Human | Esophagus | ESCC | 9.04e-07 | 9.45e-01 | 0.0655 |
57016 | AKR1B10 | P1T-E | Human | Esophagus | ESCC | 1.26e-02 | 1.72e-01 | 0.0875 |
57016 | AKR1B10 | P4T-E | Human | Esophagus | ESCC | 7.56e-09 | 4.06e-01 | 0.1323 |
57016 | AKR1B10 | P9T-E | Human | Esophagus | ESCC | 5.05e-79 | 3.25e+00 | 0.1131 |
57016 | AKR1B10 | P10T-E | Human | Esophagus | ESCC | 4.83e-03 | -9.32e-03 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199074821 | Stomach | CSG | cellular detoxification | 25/1034 | 116/18723 | 3.47e-09 | 3.75e-07 | 25 |
GO:01202542 | Stomach | CSG | olefinic compound metabolic process | 20/1034 | 153/18723 | 2.95e-04 | 5.09e-03 | 20 |
GO:00306382 | Stomach | CSG | polyketide metabolic process | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00306472 | Stomach | CSG | aminoglycoside antibiotic metabolic process | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00445982 | Stomach | CSG | doxorubicin metabolic process | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00343082 | Stomach | CSG | primary alcohol metabolic process | 13/1034 | 102/18723 | 4.01e-03 | 3.48e-02 | 13 |
GO:01100962 | Stomach | CSG | cellular response to aldehyde | 4/1034 | 13/18723 | 4.43e-03 | 3.75e-02 | 4 |
GO:19026441 | Stomach | CSG | tertiary alcohol metabolic process | 5/1034 | 21/18723 | 4.93e-03 | 4.08e-02 | 5 |
GO:009875431 | Stomach | CAG | detoxification | 21/552 | 152/18723 | 4.15e-09 | 6.72e-07 | 21 |
GO:000963631 | Stomach | CAG | response to toxic substance | 28/552 | 262/18723 | 4.37e-09 | 6.72e-07 | 28 |
GO:009723731 | Stomach | CAG | cellular response to toxic substance | 17/552 | 124/18723 | 1.40e-07 | 1.23e-05 | 17 |
GO:199074831 | Stomach | CAG | cellular detoxification | 16/552 | 116/18723 | 3.00e-07 | 2.39e-05 | 16 |
GO:01100963 | Stomach | CAG | cellular response to aldehyde | 3/552 | 13/18723 | 5.85e-03 | 4.73e-02 | 3 |
GO:00972374 | Stomach | WIM | cellular response to toxic substance | 16/426 | 124/18723 | 2.24e-08 | 2.78e-06 | 16 |
GO:19907484 | Stomach | WIM | cellular detoxification | 15/426 | 116/18723 | 6.00e-08 | 6.26e-06 | 15 |
GO:00987544 | Stomach | WIM | detoxification | 17/426 | 152/18723 | 7.04e-08 | 7.15e-06 | 17 |
GO:00096364 | Stomach | WIM | response to toxic substance | 20/426 | 262/18723 | 2.58e-06 | 1.65e-04 | 20 |
GO:01202543 | Stomach | WIM | olefinic compound metabolic process | 12/426 | 153/18723 | 2.03e-04 | 4.67e-03 | 12 |
GO:01100964 | Stomach | WIM | cellular response to aldehyde | 3/426 | 13/18723 | 2.82e-03 | 3.11e-02 | 3 |
GO:00987545 | Stomach | SIM | detoxification | 27/708 | 152/18723 | 1.79e-11 | 5.62e-09 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa000512 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0005111 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa005615 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa0056112 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa005614 | Stomach | GC | Glycerolipid metabolism | 12/708 | 63/8465 | 5.36e-03 | 3.01e-02 | 2.12e-02 | 12 |
hsa0056111 | Stomach | GC | Glycerolipid metabolism | 12/708 | 63/8465 | 5.36e-03 | 3.01e-02 | 2.12e-02 | 12 |
hsa0056121 | Stomach | SIM | Glycerolipid metabolism | 9/465 | 63/8465 | 7.07e-03 | 4.30e-02 | 3.45e-02 | 9 |
hsa0056131 | Stomach | SIM | Glycerolipid metabolism | 9/465 | 63/8465 | 7.07e-03 | 4.30e-02 | 3.45e-02 | 9 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKR1B10 | SNV | Missense_Mutation | c.116N>A | p.Gly39Glu | p.G39E | O60218 | protein_coding | deleterious(0) | possibly_damaging(0.609) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
AKR1B10 | SNV | Missense_Mutation | rs781593224 | c.914N>G | p.Ser305Cys | p.S305C | O60218 | protein_coding | tolerated(0.06) | benign(0.089) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AKR1B10 | SNV | Missense_Mutation | c.181N>C | p.Glu61Gln | p.E61Q | O60218 | protein_coding | tolerated(0.35) | benign(0.067) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AKR1B10 | SNV | Missense_Mutation | rs373551927 | c.582N>T | p.Glu194Asp | p.E194D | O60218 | protein_coding | tolerated(0.07) | benign(0.073) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AKR1B10 | SNV | Missense_Mutation | novel | c.856N>C | p.Met286Leu | p.M286L | O60218 | protein_coding | deleterious(0.03) | benign(0.302) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AKR1B10 | SNV | Missense_Mutation | rs563438026 | c.911N>T | p.Ser304Phe | p.S304F | O60218 | protein_coding | tolerated(0.31) | benign(0.033) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AKR1B10 | SNV | Missense_Mutation | novel | c.80A>C | p.Lys27Thr | p.K27T | O60218 | protein_coding | tolerated(0.09) | benign(0.348) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
AKR1B10 | SNV | Missense_Mutation | c.388A>T | p.Asn130Tyr | p.N130Y | O60218 | protein_coding | deleterious(0.02) | benign(0.37) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
AKR1B10 | SNV | Missense_Mutation | c.823C>A | p.Gln275Lys | p.Q275K | O60218 | protein_coding | tolerated(0.42) | benign(0.096) | TCGA-DM-A1DB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AKR1B10 | SNV | Missense_Mutation | novel | c.313C>A | p.Leu105Met | p.L105M | O60218 | protein_coding | deleterious(0.03) | probably_damaging(0.966) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57016 | AKR1B10 | DRUGGABLE GENOME, ENZYME | TOLRESTAT | TOLRESTAT | 21561086 | |
57016 | AKR1B10 | DRUGGABLE GENOME, ENZYME | OLEANOLIC_ACID | OLEANOLIC_ACID | 21561086 | |
57016 | AKR1B10 | DRUGGABLE GENOME, ENZYME | URSOLIC ACID | URSOLIC ACID | 21561086 | |
57016 | AKR1B10 | DRUGGABLE GENOME, ENZYME | ENOXOLONE | ENOXOLONE | 21561086 |
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