Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PHB2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PHB2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PHB2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PHB2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PHB2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PHB2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PHB2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PHB2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PHB2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005081718 | Thyroid | ATC | coagulation | 94/6293 | 222/18723 | 3.92e-03 | 1.70e-02 | 94 |
GO:00327608 | Thyroid | ATC | positive regulation of tumor necrosis factor production | 48/6293 | 103/18723 | 4.14e-03 | 1.76e-02 | 48 |
GO:003052015 | Thyroid | ATC | intracellular estrogen receptor signaling pathway | 28/6293 | 54/18723 | 4.27e-03 | 1.80e-02 | 28 |
GO:00220381 | Thyroid | ATC | corpus callosum development | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
GO:00974853 | Thyroid | ATC | neuron projection guidance | 96/6293 | 228/18723 | 4.36e-03 | 1.81e-02 | 96 |
GO:006068813 | Thyroid | ATC | regulation of morphogenesis of a branching structure | 26/6293 | 50/18723 | 5.51e-03 | 2.24e-02 | 26 |
GO:190122232 | Thyroid | ATC | regulation of NIK/NF-kappaB signaling | 51/6293 | 112/18723 | 5.68e-03 | 2.30e-02 | 51 |
GO:19035576 | Thyroid | ATC | positive regulation of tumor necrosis factor superfamily cytokine production | 49/6293 | 107/18723 | 5.79e-03 | 2.34e-02 | 49 |
GO:00434333 | Thyroid | ATC | negative regulation of DNA-binding transcription factor activity | 79/6293 | 185/18723 | 5.96e-03 | 2.40e-02 | 79 |
GO:0050678110 | Thyroid | ATC | regulation of epithelial cell proliferation | 151/6293 | 381/18723 | 7.47e-03 | 2.92e-02 | 151 |
GO:004400311 | Thyroid | ATC | modulation by symbiont of host process | 12/6293 | 19/18723 | 7.97e-03 | 3.08e-02 | 12 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
GO:01403744 | Thyroid | ATC | antiviral innate immune response | 10/6293 | 15/18723 | 9.05e-03 | 3.39e-02 | 10 |
GO:00716791 | Thyroid | ATC | commissural neuron axon guidance | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
GO:003314611 | Thyroid | ATC | regulation of intracellular estrogen receptor signaling pathway | 19/6293 | 35/18723 | 9.36e-03 | 3.44e-02 | 19 |
GO:00107216 | Thyroid | ATC | negative regulation of cell development | 76/6293 | 180/18723 | 9.50e-03 | 3.49e-02 | 76 |
GO:1903034111 | Thyroid | ATC | regulation of response to wounding | 71/6293 | 167/18723 | 9.88e-03 | 3.61e-02 | 71 |
GO:003359817 | Thyroid | ATC | mammary gland epithelial cell proliferation | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
GO:0050878112 | Thyroid | ATC | regulation of body fluid levels | 149/6293 | 379/18723 | 1.08e-02 | 3.90e-02 | 149 |
GO:00101558 | Thyroid | ATC | regulation of proton transport | 14/6293 | 24/18723 | 1.12e-02 | 4.00e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHB2 | SNV | Missense_Mutation | | c.896A>C | p.Lys299Thr | p.K299T | Q99623 | protein_coding | deleterious_low_confidence(0) | benign(0.143) | TCGA-EW-A1PE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
PHB2 | insertion | Frame_Shift_Ins | novel | c.377_378insATTGGGAATTA | p.Asp127LeufsTer31 | p.D127Lfs*31 | Q99623 | protein_coding | | | TCGA-A8-A08T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PHB2 | SNV | Missense_Mutation | | c.415N>C | p.Glu139Gln | p.E139Q | Q99623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHB2 | insertion | Frame_Shift_Ins | novel | c.44_45insCCCAT | p.Arg17CysfsTer9 | p.R17Cfs*9 | Q99623 | protein_coding | | | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHB2 | insertion | Frame_Shift_Ins | novel | c.43_44insT | p.Gly15ValfsTer68 | p.G15Vfs*68 | Q99623 | protein_coding | | | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHB2 | SNV | Missense_Mutation | rs782150944 | c.368G>A | p.Arg123His | p.R123H | Q99623 | protein_coding | tolerated(0.14) | benign(0.013) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PHB2 | SNV | Missense_Mutation | | c.283N>T | p.Gly95Cys | p.G95C | Q99623 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHB2 | SNV | Missense_Mutation | novel | c.754C>T | p.Arg252Cys | p.R252C | Q99623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PHB2 | SNV | Missense_Mutation | novel | c.895A>C | p.Lys299Gln | p.K299Q | Q99623 | protein_coding | deleterious_low_confidence(0.01) | benign(0.146) | TCGA-AX-A2IO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
PHB2 | SNV | Missense_Mutation | | c.196N>C | p.Glu66Gln | p.E66Q | Q99623 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |