GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004563920 | Thyroid | HT | positive regulation of myeloid cell differentiation | 17/1272 | 103/18723 | 5.50e-04 | 6.52e-03 | 17 |
GO:19021078 | Thyroid | HT | positive regulation of leukocyte differentiation | 22/1272 | 157/18723 | 9.54e-04 | 9.83e-03 | 22 |
GO:19037088 | Thyroid | HT | positive regulation of hemopoiesis | 22/1272 | 157/18723 | 9.54e-04 | 9.83e-03 | 22 |
GO:003166826 | Thyroid | HT | cellular response to extracellular stimulus | 30/1272 | 246/18723 | 1.34e-03 | 1.29e-02 | 30 |
GO:003166926 | Thyroid | HT | cellular response to nutrient levels | 27/1272 | 215/18723 | 1.49e-03 | 1.38e-02 | 27 |
GO:00027635 | Thyroid | HT | positive regulation of myeloid leukocyte differentiation | 10/1272 | 58/18723 | 5.30e-03 | 3.51e-02 | 10 |
GO:000257320 | Thyroid | HT | myeloid leukocyte differentiation | 24/1272 | 208/18723 | 7.69e-03 | 4.54e-02 | 24 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:1903311112 | Thyroid | PTC | regulation of mRNA metabolic process | 181/5968 | 288/18723 | 1.60e-27 | 5.94e-25 | 181 |
GO:0034976113 | Thyroid | PTC | response to endoplasmic reticulum stress | 161/5968 | 256/18723 | 1.14e-24 | 3.27e-22 | 161 |
GO:0050684112 | Thyroid | PTC | regulation of mRNA processing | 98/5968 | 137/18723 | 1.53e-21 | 3.10e-19 | 98 |
GO:0043484113 | Thyroid | PTC | regulation of RNA splicing | 102/5968 | 148/18723 | 2.03e-20 | 3.21e-18 | 102 |
GO:0097193113 | Thyroid | PTC | intrinsic apoptotic signaling pathway | 164/5968 | 288/18723 | 9.17e-19 | 1.09e-16 | 164 |
GO:0051098113 | Thyroid | PTC | regulation of binding | 195/5968 | 363/18723 | 3.21e-18 | 3.37e-16 | 195 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:001657010 | Thyroid | PTC | histone modification | 235/5968 | 463/18723 | 1.17e-17 | 1.15e-15 | 235 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F10 | SNV | Missense_Mutation | novel | c.260N>T | p.Gly87Val | p.G87V | P00742 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
F10 | SNV | Missense_Mutation | novel | c.240N>A | p.Phe80Leu | p.F80L | P00742 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | SNV | Missense_Mutation | rs121964941 | c.1120T>C | p.Ser374Pro | p.S374P | P00742 | protein_coding | deleterious(0.03) | possibly_damaging(0.511) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
F10 | SNV | Missense_Mutation | | c.8N>A | p.Arg3His | p.R3H | P00742 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | SNV | Missense_Mutation | | c.860N>T | p.Arg287Met | p.R287M | P00742 | protein_coding | tolerated(0.11) | probably_damaging(0.95) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F10 | insertion | Frame_Shift_Ins | novel | c.950_951insCAGCCTGTTGAGGTTTGCGATTCTTGTTTCCTGGTTCGAGTCTT | p.Glu317AspfsTer16 | p.E317Dfs*16 | P00742 | protein_coding | | | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
F10 | insertion | In_Frame_Ins | novel | c.958_959insGGCCTC | p.Asp320delinsGlyProHis | p.D320delinsGPH | P00742 | protein_coding | | | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
F10 | insertion | Nonsense_Mutation | novel | c.959_960insTCTGCATCTTTAGGAAGAATGGTTGGTGTTCGTGT | p.Phe321LeufsTer4 | p.F321Lfs*4 | P00742 | protein_coding | | | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
F10 | insertion | Nonsense_Mutation | novel | c.987_988insTATACATTTTAAAATATAAA | p.Thr330TyrfsTer4 | p.T330Yfs*4 | P00742 | protein_coding | | | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
F10 | SNV | Missense_Mutation | rs201675411 | c.1016C>T | p.Ala339Val | p.A339V | P00742 | protein_coding | tolerated(1) | benign(0.147) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Apixaban | APIXABAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | BIBT986 | TANOGITRAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Trimidox | TRIMETHOPRIM/SULFADOXINE | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Emicizumab | EMICIZUMAB | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | PRT4445 | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 405067325 | OTAMIXABAN | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | SR-123781A | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | CHEMBL1908371 | IDRAPARINUX SODIUM | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | FACTOR IX | | |
2159 | F10 | DRUGGABLE GENOME, PROTEASE, ENZYME | | ANTITHROMBIN | | |