Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TP53_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TP53_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TP53_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TP53_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TP53_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TP53_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063674 | Skin | cSCC | transcription initiation from RNA polymerase II promoter | 37/4864 | 77/18723 | 2.53e-05 | 2.87e-04 | 37 |
GO:005134829 | Skin | cSCC | negative regulation of transferase activity | 100/4864 | 268/18723 | 2.60e-05 | 2.94e-04 | 100 |
GO:190198812 | Skin | cSCC | negative regulation of cell cycle phase transition | 94/4864 | 249/18723 | 2.65e-05 | 3.00e-04 | 94 |
GO:001094812 | Skin | cSCC | negative regulation of cell cycle process | 108/4864 | 294/18723 | 2.75e-05 | 3.09e-04 | 108 |
GO:000926722 | Skin | cSCC | cellular response to starvation | 64/4864 | 156/18723 | 2.79e-05 | 3.12e-04 | 64 |
GO:0030330111 | Skin | cSCC | DNA damage response, signal transduction by p53 class mediator | 35/4864 | 72/18723 | 3.05e-05 | 3.39e-04 | 35 |
GO:000007512 | Skin | cSCC | cell cycle checkpoint | 68/4864 | 169/18723 | 3.37e-05 | 3.67e-04 | 68 |
GO:0042594110 | Skin | cSCC | response to starvation | 77/4864 | 197/18723 | 3.52e-05 | 3.82e-04 | 77 |
GO:004814422 | Skin | cSCC | fibroblast proliferation | 38/4864 | 81/18723 | 3.88e-05 | 4.17e-04 | 38 |
GO:00064766 | Skin | cSCC | protein deacetylation | 45/4864 | 101/18723 | 3.97e-05 | 4.26e-04 | 45 |
GO:00708974 | Skin | cSCC | transcription preinitiation complex assembly | 21/4864 | 36/18723 | 3.98e-05 | 4.26e-04 | 21 |
GO:00987326 | Skin | cSCC | macromolecule deacylation | 50/4864 | 116/18723 | 4.47e-05 | 4.69e-04 | 50 |
GO:1902253111 | Skin | cSCC | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 18/4864 | 29/18723 | 4.51e-05 | 4.72e-04 | 18 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:00070935 | Skin | cSCC | mitotic cell cycle checkpoint | 54/4864 | 129/18723 | 5.99e-05 | 5.87e-04 | 54 |
GO:005197219 | Skin | cSCC | regulation of telomerase activity | 25/4864 | 47/18723 | 6.32e-05 | 6.18e-04 | 25 |
GO:004277015 | Skin | cSCC | signal transduction in response to DNA damage | 68/4864 | 172/18723 | 6.48e-05 | 6.31e-04 | 68 |
GO:004814522 | Skin | cSCC | regulation of fibroblast proliferation | 37/4864 | 80/18723 | 7.15e-05 | 6.87e-04 | 37 |
GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
GO:200063715 | Skin | cSCC | positive regulation of gene silencing by miRNA | 18/4864 | 30/18723 | 8.53e-05 | 8.08e-04 | 18 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TP53 | MSC | Breast | DCIS | ATP1B2,CTNNB1,F2R, etc. | 1.47e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Healthy | ATP1B2,CTNNB1,F2R, etc. | 4.25e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Precancer | ATP1B2,CTNNB1,F2R, etc. | 1.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
TP53 | ASC | Colorectum | ADJ | CATSPERE,AP000446.1,TMEM69, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TP53 | TAC | Colorectum | Healthy | ESYT1,ATAD5,GNL3, etc. | 7.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TEXINT | Lung | AAH | APOLD1,RAB27A,PHACTR2-AS1, etc. | 3.56e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AAH/regulons_activity_in_dotplot.png) |
TP53 | TH1 | Lung | Healthy | TRAT1,MRPL43,LSM14A, etc. | 8.15e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TCM | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 4.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | CD8TEFF | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 3.87e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | PVA | Lung | Healthy | HDX,LINC00960,NHEJ1, etc. | 1.10e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TP53 | SNV | Missense_Mutation | rs28934578 | c.524N>A | p.Arg175His | p.R175H | P04637 | protein_coding | tolerated(0.11) | benign(0.319) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | | c.398N>A | p.Met133Lys | p.M133K | P04637 | protein_coding | deleterious(0) | benign(0.061) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TP53 | SNV | Missense_Mutation | rs121912666 | c.659A>G | p.Tyr220Cys | p.Y220C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
TP53 | SNV | Missense_Mutation | rs28934576 | c.818N>A | p.Arg273His | p.R273H | P04637 | protein_coding | tolerated(0.13) | possibly_damaging(0.643) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TP53 | SNV | Missense_Mutation | | c.623N>G | p.Asp208Gly | p.D208G | P04637 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TP53 | SNV | Missense_Mutation | rs121912657 | c.814N>A | p.Val272Met | p.V272M | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TP53 | SNV | Missense_Mutation | rs28934576 | c.818G>T | p.Arg273Leu | p.R273L | P04637 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
TP53 | SNV | Missense_Mutation | | c.691A>C | p.Thr231Pro | p.T231P | P04637 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
TP53 | SNV | Missense_Mutation | rs587780073 | c.701N>G | p.Tyr234Cys | p.Y234C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TP53 | SNV | Missense_Mutation | rs148924904 | c.488N>G | p.Tyr163Cys | p.Y163C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0ST-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CAULIBUGULONE D | CAULIBUGULONE D | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | fluorouracil | FLUOROURACIL | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CID 867101 | CHEMBL406557 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | SJ000276790 | CHEMBL602922 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | OLEOYL DOPAMINE | OLEOYL DOPAMINE | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1417085 | CHEMBL1522984 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1340257 | CHEMBL1702181 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | TEBUFENPYRAD | TEBUFENPYRAD | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CTX-1 | | 26883273 |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | ZM-336372 | CHEMBL186526 | |