Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PRKN_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PRKN_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PRKN_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PRKN_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006082822 | Lung | MIAC | regulation of canonical Wnt signaling pathway | 28/967 | 253/18723 | 1.23e-04 | 5.10e-03 | 28 |
GO:005082123 | Lung | MIAC | protein stabilization | 23/967 | 191/18723 | 1.40e-04 | 5.55e-03 | 23 |
GO:006219723 | Lung | MIAC | cellular response to chemical stress | 34/967 | 337/18723 | 1.54e-04 | 6.04e-03 | 34 |
GO:190305231 | Lung | MIAC | positive regulation of proteolysis involved in cellular protein catabolic process | 18/967 | 133/18723 | 1.68e-04 | 6.31e-03 | 18 |
GO:006056021 | Lung | MIAC | developmental growth involved in morphogenesis | 26/967 | 234/18723 | 1.99e-04 | 7.15e-03 | 26 |
GO:003243622 | Lung | MIAC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 14/967 | 90/18723 | 2.02e-04 | 7.19e-03 | 14 |
GO:199013821 | Lung | MIAC | neuron projection extension | 21/967 | 172/18723 | 2.21e-04 | 7.66e-03 | 21 |
GO:006007022 | Lung | MIAC | canonical Wnt signaling pathway | 31/967 | 303/18723 | 2.31e-04 | 7.86e-03 | 31 |
GO:001603223 | Lung | MIAC | viral process | 39/967 | 415/18723 | 2.34e-04 | 7.89e-03 | 39 |
GO:001003823 | Lung | MIAC | response to metal ion | 36/967 | 373/18723 | 2.40e-04 | 8.06e-03 | 36 |
GO:200123432 | Lung | MIAC | negative regulation of apoptotic signaling pathway | 25/967 | 224/18723 | 2.45e-04 | 8.13e-03 | 25 |
GO:190547721 | Lung | MIAC | positive regulation of protein localization to membrane | 15/967 | 106/18723 | 3.52e-04 | 1.04e-02 | 15 |
GO:004340931 | Lung | MIAC | negative regulation of MAPK cascade | 21/967 | 180/18723 | 4.12e-04 | 1.19e-02 | 21 |
GO:001648222 | Lung | MIAC | cytosolic transport | 20/967 | 168/18723 | 4.31e-04 | 1.23e-02 | 20 |
GO:003109831 | Lung | MIAC | stress-activated protein kinase signaling cascade | 26/967 | 247/18723 | 4.65e-04 | 1.27e-02 | 26 |
GO:009719333 | Lung | MIAC | intrinsic apoptotic signaling pathway | 29/967 | 288/18723 | 4.72e-04 | 1.29e-02 | 29 |
GO:004858821 | Lung | MIAC | developmental cell growth | 25/967 | 234/18723 | 4.75e-04 | 1.29e-02 | 25 |
GO:003243432 | Lung | MIAC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 17/967 | 134/18723 | 5.45e-04 | 1.40e-02 | 17 |
GO:005140331 | Lung | MIAC | stress-activated MAPK cascade | 25/967 | 239/18723 | 6.50e-04 | 1.56e-02 | 25 |
GO:001604922 | Lung | MIAC | cell growth | 42/967 | 482/18723 | 6.66e-04 | 1.59e-02 | 42 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |