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Gene: ADA |
Gene summary for ADA |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADA | Gene ID | 100 |
| Gene name | adenosine deaminase | |
| Gene Alias | ADA1 | |
| Cytomap | 20q13.12 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A0S2Z381 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100 | ADA | LZE4T | Human | Esophagus | ESCC | 2.96e-05 | 2.97e-01 | 0.0811 |
| 100 | ADA | LZE7T | Human | Esophagus | ESCC | 7.23e-05 | 4.14e-01 | 0.0667 |
| 100 | ADA | LZE8T | Human | Esophagus | ESCC | 2.46e-03 | 2.89e-01 | 0.067 |
| 100 | ADA | P2T-E | Human | Esophagus | ESCC | 2.46e-16 | 3.07e-01 | 0.1177 |
| 100 | ADA | P4T-E | Human | Esophagus | ESCC | 2.34e-10 | 3.84e-01 | 0.1323 |
| 100 | ADA | P5T-E | Human | Esophagus | ESCC | 3.01e-27 | 6.22e-01 | 0.1327 |
| 100 | ADA | P9T-E | Human | Esophagus | ESCC | 4.85e-10 | 3.77e-01 | 0.1131 |
| 100 | ADA | P10T-E | Human | Esophagus | ESCC | 1.21e-09 | 2.14e-01 | 0.116 |
| 100 | ADA | P11T-E | Human | Esophagus | ESCC | 8.00e-15 | 6.26e-01 | 0.1426 |
| 100 | ADA | P15T-E | Human | Esophagus | ESCC | 2.50e-42 | 1.01e+00 | 0.1149 |
| 100 | ADA | P16T-E | Human | Esophagus | ESCC | 3.70e-08 | 1.29e-01 | 0.1153 |
| 100 | ADA | P17T-E | Human | Esophagus | ESCC | 5.97e-07 | 5.12e-01 | 0.1278 |
| 100 | ADA | P20T-E | Human | Esophagus | ESCC | 1.20e-14 | 2.66e-01 | 0.1124 |
| 100 | ADA | P22T-E | Human | Esophagus | ESCC | 2.56e-26 | 5.20e-01 | 0.1236 |
| 100 | ADA | P23T-E | Human | Esophagus | ESCC | 6.28e-14 | 3.08e-01 | 0.108 |
| 100 | ADA | P24T-E | Human | Esophagus | ESCC | 1.70e-12 | 3.36e-01 | 0.1287 |
| 100 | ADA | P26T-E | Human | Esophagus | ESCC | 6.47e-29 | 6.46e-01 | 0.1276 |
| 100 | ADA | P27T-E | Human | Esophagus | ESCC | 3.41e-07 | 2.32e-01 | 0.1055 |
| 100 | ADA | P28T-E | Human | Esophagus | ESCC | 3.25e-29 | 6.27e-01 | 0.1149 |
| 100 | ADA | P30T-E | Human | Esophagus | ESCC | 3.12e-08 | 4.24e-01 | 0.137 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00106347 | Lung | IAC | positive regulation of epithelial cell migration | 36/2061 | 176/18723 | 1.73e-04 | 3.07e-03 | 36 |
| GO:00303076 | Lung | IAC | positive regulation of cell growth | 34/2061 | 166/18723 | 2.52e-04 | 4.24e-03 | 34 |
| GO:00434103 | Lung | IAC | positive regulation of MAPK cascade | 78/2061 | 480/18723 | 2.72e-04 | 4.50e-03 | 78 |
| GO:19019902 | Lung | IAC | regulation of mitotic cell cycle phase transition | 53/2061 | 299/18723 | 3.14e-04 | 4.98e-03 | 53 |
| GO:00515924 | Lung | IAC | response to calcium ion | 31/2061 | 149/18723 | 3.47e-04 | 5.42e-03 | 31 |
| GO:00434052 | Lung | IAC | regulation of MAP kinase activity | 35/2061 | 177/18723 | 4.15e-04 | 6.23e-03 | 35 |
| GO:00346127 | Lung | IAC | response to tumor necrosis factor | 46/2061 | 253/18723 | 4.28e-04 | 6.37e-03 | 46 |
| GO:00071785 | Lung | IAC | transmembrane receptor protein serine/threonine kinase signaling pathway | 60/2061 | 355/18723 | 4.82e-04 | 7.03e-03 | 60 |
| GO:0033627 | Lung | IAC | cell adhesion mediated by integrin | 18/2061 | 72/18723 | 6.34e-04 | 8.68e-03 | 18 |
| GO:00421106 | Lung | IAC | T cell activation | 77/2061 | 487/18723 | 6.82e-04 | 9.20e-03 | 77 |
| GO:20000452 | Lung | IAC | regulation of G1/S transition of mitotic cell cycle | 29/2061 | 142/18723 | 7.27e-04 | 9.60e-03 | 29 |
| GO:19038444 | Lung | IAC | regulation of cellular response to transforming growth factor beta stimulus | 27/2061 | 131/18723 | 9.41e-04 | 1.14e-02 | 27 |
| GO:00100388 | Lung | IAC | response to metal ion | 61/2061 | 373/18723 | 1.02e-03 | 1.22e-02 | 61 |
| GO:00900684 | Lung | IAC | positive regulation of cell cycle process | 42/2061 | 236/18723 | 1.15e-03 | 1.35e-02 | 42 |
| GO:00713567 | Lung | IAC | cellular response to tumor necrosis factor | 41/2061 | 229/18723 | 1.16e-03 | 1.35e-02 | 41 |
| GO:00099135 | Lung | IAC | epidermal cell differentiation | 37/2061 | 202/18723 | 1.29e-03 | 1.45e-02 | 37 |
| GO:00459314 | Lung | IAC | positive regulation of mitotic cell cycle | 25/2061 | 121/18723 | 1.38e-03 | 1.53e-02 | 25 |
| GO:19028061 | Lung | IAC | regulation of cell cycle G1/S phase transition | 32/2061 | 168/18723 | 1.38e-03 | 1.53e-02 | 32 |
| GO:00513847 | Lung | IAC | response to glucocorticoid | 29/2061 | 148/18723 | 1.44e-03 | 1.55e-02 | 29 |
| GO:00170153 | Lung | IAC | regulation of transforming growth factor beta receptor signaling pathway | 26/2061 | 128/18723 | 1.45e-03 | 1.55e-02 | 26 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADA | SNV | Missense_Mutation | c.217N>A | p.Ala73Thr | p.A73T | P00813 | protein_coding | deleterious(0.01) | benign(0.386) | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | |
| ADA | SNV | Missense_Mutation | rs748974674 | c.935N>G | p.Lys312Arg | p.K312R | P00813 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-A8-A08O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | PD |
| ADA | SNV | Missense_Mutation | rs121908721 | c.872N>T | p.Ser291Leu | p.S291L | P00813 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A1HE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ADA | insertion | Frame_Shift_Ins | novel | c.1006_1007insTGGGTACTACAAGTTG | p.Pro336LeufsTer9 | p.P336Lfs*9 | P00813 | protein_coding | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
| ADA | insertion | Frame_Shift_Ins | novel | c.946_947insT | p.Gly316ValfsTer4 | p.G316Vfs*4 | P00813 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
| ADA | insertion | Nonsense_Mutation | novel | c.944_945insCCCAGGCTGAATAAGTCCATTCCTGCACGTGTCTGCGA | p.Met315IlefsTer4 | p.M315Ifs*4 | P00813 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
| ADA | SNV | Missense_Mutation | c.347C>T | p.Pro116Leu | p.P116L | P00813 | protein_coding | deleterious(0.01) | possibly_damaging(0.614) | TCGA-EX-A69L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ADA | SNV | Missense_Mutation | novel | c.340N>A | p.Pro114Thr | p.P114T | P00813 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADA | SNV | Missense_Mutation | c.824N>G | p.Asp275Gly | p.D275G | P00813 | protein_coding | tolerated(0.15) | benign(0.045) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ADA | SNV | Missense_Mutation | c.754N>A | p.Leu252Met | p.L252M | P00813 | protein_coding | deleterious(0.05) | probably_damaging(0.987) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | 2,3-DIDEOXYADENOSINE | 3496090 | ||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | PENTOSTATIN | PENTOSTATIN | ||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | DIPYRIDAMOLE | DIPYRIDAMOLE | ||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | inhibitor | 178101507 | PENTOSTATIN | |
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | 6-METHYLMERCAPTOPURINE RIBOSIDE | 10102 | ||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy | |||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | HYDROCORTISONE | HYDROCORTISONE | 2395837 | |
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Pentostatin | PENTOSTATIN | ||
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | CORDYCEPIN | CORDYCEPIN | 24283924 | |
| 100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | COBALT | 9144774 |
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