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Gene: CDK5 |
Gene summary for CDK5 |
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Gene information | Species | Human | Gene symbol | CDK5 | Gene ID | 1020 |
Gene name | cyclin dependent kinase 5 | |
Gene Alias | LIS7 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | A0A0S2Z355 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1020 | CDK5 | LZE4T | Human | Esophagus | ESCC | 4.55e-06 | 1.94e-01 | 0.0811 |
1020 | CDK5 | LZE7T | Human | Esophagus | ESCC | 1.88e-02 | 3.23e-01 | 0.0667 |
1020 | CDK5 | LZE8T | Human | Esophagus | ESCC | 2.31e-02 | 1.73e-01 | 0.067 |
1020 | CDK5 | LZE24T | Human | Esophagus | ESCC | 6.38e-13 | 3.69e-01 | 0.0596 |
1020 | CDK5 | LZE6T | Human | Esophagus | ESCC | 1.64e-08 | 2.98e-01 | 0.0845 |
1020 | CDK5 | P1T-E | Human | Esophagus | ESCC | 5.30e-03 | 2.31e-01 | 0.0875 |
1020 | CDK5 | P2T-E | Human | Esophagus | ESCC | 1.29e-08 | 1.67e-01 | 0.1177 |
1020 | CDK5 | P4T-E | Human | Esophagus | ESCC | 8.04e-31 | 6.63e-01 | 0.1323 |
1020 | CDK5 | P5T-E | Human | Esophagus | ESCC | 6.16e-15 | 3.12e-01 | 0.1327 |
1020 | CDK5 | P8T-E | Human | Esophagus | ESCC | 4.46e-10 | 2.21e-01 | 0.0889 |
1020 | CDK5 | P9T-E | Human | Esophagus | ESCC | 5.88e-16 | 4.02e-01 | 0.1131 |
1020 | CDK5 | P10T-E | Human | Esophagus | ESCC | 6.10e-17 | 2.89e-01 | 0.116 |
1020 | CDK5 | P11T-E | Human | Esophagus | ESCC | 3.64e-04 | 2.24e-01 | 0.1426 |
1020 | CDK5 | P12T-E | Human | Esophagus | ESCC | 4.27e-36 | 6.45e-01 | 0.1122 |
1020 | CDK5 | P15T-E | Human | Esophagus | ESCC | 2.85e-22 | 4.85e-01 | 0.1149 |
1020 | CDK5 | P16T-E | Human | Esophagus | ESCC | 9.14e-22 | 3.63e-01 | 0.1153 |
1020 | CDK5 | P17T-E | Human | Esophagus | ESCC | 2.51e-02 | 1.94e-01 | 0.1278 |
1020 | CDK5 | P19T-E | Human | Esophagus | ESCC | 1.55e-09 | 7.40e-01 | 0.1662 |
1020 | CDK5 | P20T-E | Human | Esophagus | ESCC | 1.54e-10 | 2.51e-01 | 0.1124 |
1020 | CDK5 | P21T-E | Human | Esophagus | ESCC | 2.23e-40 | 7.61e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066126 | Thyroid | PTC | protein targeting to membrane | 64/5968 | 131/18723 | 3.67e-05 | 3.41e-04 | 64 |
GO:003111610 | Thyroid | PTC | positive regulation of microtubule polymerization | 22/5968 | 33/18723 | 4.25e-05 | 3.87e-04 | 22 |
GO:1901798113 | Thyroid | PTC | positive regulation of signal transduction by p53 class mediator | 18/5968 | 25/18723 | 4.48e-05 | 4.05e-04 | 18 |
GO:003111316 | Thyroid | PTC | regulation of microtubule polymerization | 32/5968 | 55/18723 | 5.03e-05 | 4.47e-04 | 32 |
GO:000836115 | Thyroid | PTC | regulation of cell size | 83/5968 | 181/18723 | 5.45e-05 | 4.84e-04 | 83 |
GO:00903176 | Thyroid | PTC | negative regulation of intracellular protein transport | 26/5968 | 42/18723 | 5.91e-05 | 5.21e-04 | 26 |
GO:004311219 | Thyroid | PTC | receptor metabolic process | 77/5968 | 166/18723 | 6.21e-05 | 5.47e-04 | 77 |
GO:003086616 | Thyroid | PTC | cortical actin cytoskeleton organization | 25/5968 | 40/18723 | 6.51e-05 | 5.72e-04 | 25 |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:00488139 | Thyroid | PTC | dendrite morphogenesis | 69/5968 | 146/18723 | 7.12e-05 | 6.19e-04 | 69 |
GO:00323877 | Thyroid | PTC | negative regulation of intracellular transport | 33/5968 | 58/18723 | 7.13e-05 | 6.19e-04 | 33 |
GO:001092116 | Thyroid | PTC | regulation of phosphatase activity | 44/5968 | 84/18723 | 7.53e-05 | 6.48e-04 | 44 |
GO:005109016 | Thyroid | PTC | regulation of DNA-binding transcription factor activity | 178/5968 | 440/18723 | 7.63e-05 | 6.54e-04 | 178 |
GO:00991738 | Thyroid | PTC | postsynapse organization | 77/5968 | 168/18723 | 1.01e-04 | 8.25e-04 | 77 |
GO:00467858 | Thyroid | PTC | microtubule polymerization | 43/5968 | 83/18723 | 1.26e-04 | 9.98e-04 | 43 |
GO:20002499 | Thyroid | PTC | regulation of actin cytoskeleton reorganization | 24/5968 | 39/18723 | 1.30e-04 | 1.03e-03 | 24 |
GO:190402912 | Thyroid | PTC | regulation of cyclin-dependent protein kinase activity | 49/5968 | 98/18723 | 1.40e-04 | 1.09e-03 | 49 |
GO:003111210 | Thyroid | PTC | positive regulation of microtubule polymerization or depolymerization | 23/5968 | 37/18723 | 1.44e-04 | 1.12e-03 | 23 |
GO:00313459 | Thyroid | PTC | negative regulation of cell projection organization | 83/5968 | 186/18723 | 1.72e-04 | 1.32e-03 | 83 |
GO:00519608 | Thyroid | PTC | regulation of nervous system development | 177/5968 | 443/18723 | 1.72e-04 | 1.32e-03 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDK5 | SNV | Missense_Mutation | novel | c.295G>A | p.Asp99Asn | p.D99N | Q00535 | protein_coding | tolerated(0.13) | benign(0.251) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDK5 | SNV | Missense_Mutation | c.484N>T | p.Val162Leu | p.V162L | Q00535 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BH-A1EO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDK5 | SNV | Missense_Mutation | c.301N>C | p.Glu101Gln | p.E101Q | Q00535 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
CDK5 | SNV | Missense_Mutation | novel | c.488N>G | p.Val163Gly | p.V163G | Q00535 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDK5 | SNV | Missense_Mutation | c.149N>A | p.Arg50Gln | p.R50Q | Q00535 | protein_coding | deleterious(0.02) | possibly_damaging(0.876) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDK5 | SNV | Missense_Mutation | novel | c.271N>G | p.Phe91Val | p.F91V | Q00535 | protein_coding | deleterious(0) | possibly_damaging(0.806) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDK5 | SNV | Missense_Mutation | novel | c.31G>T | p.Gly11Trp | p.G11W | Q00535 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD |
CDK5 | SNV | Missense_Mutation | c.599G>A | p.Arg200Gln | p.R200Q | Q00535 | protein_coding | tolerated(0.14) | benign(0.011) | TCGA-DC-5869-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CDK5 | SNV | Missense_Mutation | rs548208867 | c.821N>A | p.Arg274His | p.R274H | Q00535 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CDK5 | SNV | Missense_Mutation | novel | c.846N>T | p.Gln282His | p.Q282H | Q00535 | protein_coding | tolerated(0.13) | benign(0.369) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | TAE-684 | TAE-684 | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | (RS)-ROSCOVITINE | (RS)-ROSCOVITINE | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | GW441756X | GW441756X | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | LY-2090314 | LY-2090314 | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | PALBOCICLIB | PALBOCICLIB | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | inhibitor | 178102290 | AT-7519 | |
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | PMID26161698-Compound-18 | |||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | inhibitor | 178102572 | ||
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL445813 | AT-7519 | |
1020 | CDK5 | SERINE THREONINE KINASE, KINASE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | JNJ-7706621 | JNJ-7706621 |
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