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Gene: YWHAZ |
Gene summary for YWHAZ |
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Gene information | Species | Human | Gene symbol | YWHAZ | Gene ID | 7534 |
Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | |
Gene Alias | 14-3-3-zeta | |
Cytomap | 8q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | D0PNI1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7534 | YWHAZ | GSM4909281 | Human | Breast | IDC | 1.53e-52 | 8.01e-01 | 0.21 |
7534 | YWHAZ | GSM4909285 | Human | Breast | IDC | 4.27e-06 | -7.90e-02 | 0.21 |
7534 | YWHAZ | GSM4909286 | Human | Breast | IDC | 2.31e-08 | 2.02e-01 | 0.1081 |
7534 | YWHAZ | GSM4909287 | Human | Breast | IDC | 1.39e-54 | 7.37e-01 | 0.2057 |
7534 | YWHAZ | GSM4909288 | Human | Breast | IDC | 4.52e-04 | 2.12e-01 | 0.0988 |
7534 | YWHAZ | GSM4909290 | Human | Breast | IDC | 1.63e-46 | 7.84e-01 | 0.2096 |
7534 | YWHAZ | GSM4909291 | Human | Breast | IDC | 1.46e-44 | 8.25e-01 | 0.1753 |
7534 | YWHAZ | GSM4909293 | Human | Breast | IDC | 2.43e-45 | 7.05e-01 | 0.1581 |
7534 | YWHAZ | GSM4909294 | Human | Breast | IDC | 3.49e-07 | 2.07e-01 | 0.2022 |
7534 | YWHAZ | GSM4909295 | Human | Breast | IDC | 5.60e-04 | 3.82e-01 | 0.0898 |
7534 | YWHAZ | GSM4909296 | Human | Breast | IDC | 2.44e-09 | -1.93e-01 | 0.1524 |
7534 | YWHAZ | GSM4909297 | Human | Breast | IDC | 1.85e-14 | -1.69e-02 | 0.1517 |
7534 | YWHAZ | GSM4909298 | Human | Breast | IDC | 3.28e-03 | 2.20e-01 | 0.1551 |
7534 | YWHAZ | GSM4909301 | Human | Breast | IDC | 8.77e-05 | 3.41e-01 | 0.1577 |
7534 | YWHAZ | GSM4909302 | Human | Breast | IDC | 2.82e-03 | 1.80e-01 | 0.1545 |
7534 | YWHAZ | GSM4909304 | Human | Breast | IDC | 4.73e-43 | 6.66e-01 | 0.1636 |
7534 | YWHAZ | GSM4909305 | Human | Breast | IDC | 2.98e-09 | 4.31e-01 | 0.0436 |
7534 | YWHAZ | GSM4909306 | Human | Breast | IDC | 7.65e-34 | 6.50e-01 | 0.1564 |
7534 | YWHAZ | GSM4909308 | Human | Breast | IDC | 5.48e-19 | 5.08e-01 | 0.158 |
7534 | YWHAZ | GSM4909309 | Human | Breast | IDC | 1.21e-09 | 2.56e-01 | 0.0483 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00080381 | Skin | SCCIS | neuron recognition | 8/919 | 49/18723 | 2.46e-03 | 2.40e-02 | 8 |
GO:003514817 | Skin | SCCIS | tube formation | 16/919 | 148/18723 | 2.52e-03 | 2.44e-02 | 16 |
GO:0006605112 | Skin | SCCIS | protein targeting | 26/919 | 314/18723 | 6.62e-03 | 4.90e-02 | 26 |
GO:000660527 | Skin | cSCC | protein targeting | 153/4864 | 314/18723 | 2.62e-18 | 3.36e-16 | 153 |
GO:005165624 | Skin | cSCC | establishment of organelle localization | 178/4864 | 390/18723 | 2.18e-17 | 2.32e-15 | 178 |
GO:00070309 | Skin | cSCC | Golgi organization | 64/4864 | 157/18723 | 3.53e-05 | 3.83e-04 | 64 |
GO:00483084 | Skin | cSCC | organelle inheritance | 11/4864 | 15/18723 | 1.67e-04 | 1.45e-03 | 11 |
GO:00483134 | Skin | cSCC | Golgi inheritance | 11/4864 | 15/18723 | 1.67e-04 | 1.45e-03 | 11 |
GO:00516456 | Skin | cSCC | Golgi localization | 9/4864 | 14/18723 | 2.87e-03 | 1.60e-02 | 9 |
GO:003514822 | Skin | cSCC | tube formation | 54/4864 | 148/18723 | 3.00e-03 | 1.66e-02 | 54 |
GO:003032417 | Skin | cSCC | lung development | 60/4864 | 177/18723 | 1.14e-02 | 4.97e-02 | 60 |
GO:00066056 | Stomach | GC | protein targeting | 34/1159 | 314/18723 | 1.09e-03 | 1.27e-02 | 34 |
GO:000660511 | Stomach | CAG with IM | protein targeting | 33/1050 | 314/18723 | 3.98e-04 | 6.38e-03 | 33 |
GO:000660521 | Stomach | CSG | protein targeting | 33/1034 | 314/18723 | 3.03e-04 | 5.20e-03 | 33 |
GO:000660531 | Stomach | CAG | protein targeting | 24/552 | 314/18723 | 2.18e-05 | 7.92e-04 | 24 |
GO:000660541 | Stomach | WIM | protein targeting | 20/426 | 314/18723 | 3.70e-05 | 1.24e-03 | 20 |
GO:000660551 | Stomach | SIM | protein targeting | 27/708 | 314/18723 | 6.56e-05 | 1.70e-03 | 27 |
GO:000660528 | Thyroid | HT | protein targeting | 46/1272 | 314/18723 | 6.55e-07 | 2.70e-05 | 46 |
GO:00080371 | Thyroid | HT | cell recognition | 31/1272 | 225/18723 | 1.35e-04 | 2.12e-03 | 31 |
GO:003032418 | Thyroid | HT | lung development | 25/1272 | 177/18723 | 3.95e-04 | 4.93e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520341 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa052035 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa051602 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa05161 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa051603 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa051611 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa04110 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041101 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YWHAZ | SNV | Missense_Mutation | c.697N>G | p.Gln233Glu | p.Q233E | P63104 | protein_coding | tolerated_low_confidence(0.18) | benign(0.052) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
YWHAZ | SNV | Missense_Mutation | novel | c.629N>T | p.Ser210Leu | p.S210L | P63104 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.5) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
YWHAZ | SNV | Missense_Mutation | c.98G>C | p.Gly33Ala | p.G33A | P63104 | protein_coding | deleterious_low_confidence(0.03) | benign(0.307) | TCGA-C8-A26V-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | CR | |
YWHAZ | SNV | Missense_Mutation | c.451N>C | p.Glu151Gln | p.E151Q | P63104 | protein_coding | tolerated_low_confidence(0.07) | benign(0.035) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
YWHAZ | SNV | Missense_Mutation | novel | c.289N>A | p.Val97Ile | p.V97I | P63104 | protein_coding | tolerated_low_confidence(0.45) | possibly_damaging(0.632) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
YWHAZ | SNV | Missense_Mutation | c.684N>C | p.Trp228Cys | p.W228C | P63104 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
YWHAZ | SNV | Missense_Mutation | novel | c.629N>T | p.Ser210Leu | p.S210L | P63104 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.5) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
YWHAZ | SNV | Missense_Mutation | c.13N>C | p.Glu5Gln | p.E5Q | P63104 | protein_coding | tolerated_low_confidence(0.09) | benign(0.031) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
YWHAZ | SNV | Missense_Mutation | novel | c.505N>T | p.Gly169Cys | p.G169C | P63104 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.997) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
YWHAZ | insertion | Frame_Shift_Ins | novel | c.225_226insA | p.Gln76ThrfsTer12 | p.Q76Tfs*12 | P63104 | protein_coding | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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