Tissue | Expression Dynamics | Abbreviation |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/WDR6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/WDR6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/WDR6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/WDR6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000989517 | Prostate | BPH | negative regulation of catabolic process | 94/3107 | 320/18723 | 6.79e-09 | 2.38e-07 | 94 |
GO:003133018 | Prostate | BPH | negative regulation of cellular catabolic process | 79/3107 | 262/18723 | 3.09e-08 | 8.91e-07 | 79 |
GO:00165706 | Prostate | BPH | histone modification | 120/3107 | 463/18723 | 1.73e-07 | 3.89e-06 | 120 |
GO:190370616 | Prostate | BPH | regulation of hemopoiesis | 97/3107 | 367/18723 | 1.01e-06 | 1.83e-05 | 97 |
GO:00105069 | Prostate | BPH | regulation of autophagy | 86/3107 | 317/18723 | 1.29e-06 | 2.24e-05 | 86 |
GO:004563718 | Prostate | BPH | regulation of myeloid cell differentiation | 62/3107 | 210/18723 | 1.99e-06 | 3.30e-05 | 62 |
GO:00182055 | Prostate | BPH | peptidyl-lysine modification | 96/3107 | 376/18723 | 5.70e-06 | 8.39e-05 | 96 |
GO:00063546 | Prostate | BPH | DNA-templated transcription, elongation | 30/3107 | 91/18723 | 9.63e-05 | 9.00e-04 | 30 |
GO:00349686 | Prostate | BPH | histone lysine methylation | 35/3107 | 115/18723 | 1.64e-04 | 1.42e-03 | 35 |
GO:00063685 | Prostate | BPH | transcription elongation from RNA polymerase II promoter | 24/3107 | 69/18723 | 1.85e-04 | 1.55e-03 | 24 |
GO:00064796 | Prostate | BPH | protein methylation | 49/3107 | 181/18723 | 2.42e-04 | 1.93e-03 | 49 |
GO:00082136 | Prostate | BPH | protein alkylation | 49/3107 | 181/18723 | 2.42e-04 | 1.93e-03 | 49 |
GO:00165716 | Prostate | BPH | histone methylation | 40/3107 | 141/18723 | 3.09e-04 | 2.37e-03 | 40 |
GO:00310566 | Prostate | BPH | regulation of histone modification | 42/3107 | 152/18723 | 4.09e-04 | 2.97e-03 | 42 |
GO:00515682 | Prostate | BPH | histone H3-K4 methylation | 20/3107 | 59/18723 | 9.02e-04 | 5.78e-03 | 20 |
GO:0080182 | Prostate | BPH | histone H3-K4 trimethylation | 9/3107 | 18/18723 | 1.09e-03 | 6.77e-03 | 9 |
GO:00180225 | Prostate | BPH | peptidyl-lysine methylation | 35/3107 | 131/18723 | 2.23e-03 | 1.23e-02 | 35 |
GO:0045638 | Prostate | BPH | negative regulation of myeloid cell differentiation | 26/3107 | 90/18723 | 2.46e-03 | 1.33e-02 | 26 |
GO:00310602 | Prostate | BPH | regulation of histone methylation | 20/3107 | 69/18723 | 7.06e-03 | 3.16e-02 | 20 |
GO:00515712 | Prostate | BPH | positive regulation of histone H3-K4 methylation | 8/3107 | 19/18723 | 7.65e-03 | 3.39e-02 | 8 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR6 | SNV | Missense_Mutation | novel | c.3151G>A | p.Glu1051Lys | p.E1051K | | protein_coding | tolerated(0.35) | benign(0.015) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
WDR6 | SNV | Missense_Mutation | novel | c.2837N>C | p.Val946Ala | p.V946A | | protein_coding | deleterious(0.03) | possibly_damaging(0.597) | TCGA-A7-A5ZW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
WDR6 | SNV | Missense_Mutation | | c.2764N>G | p.Leu922Val | p.L922V | | protein_coding | tolerated(0.6) | benign(0.005) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WDR6 | SNV | Missense_Mutation | | c.613N>G | p.Ile205Val | p.I205V | | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR6 | SNV | Missense_Mutation | rs61732633 | c.2417N>T | p.Ser806Leu | p.S806L | | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
WDR6 | SNV | Missense_Mutation | | c.3394G>C | p.Glu1132Gln | p.E1132Q | | protein_coding | tolerated(0.16) | possibly_damaging(0.857) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR6 | SNV | Missense_Mutation | | c.1507N>C | p.Gly503Arg | p.G503R | | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
WDR6 | SNV | Missense_Mutation | rs542788663 | c.1960N>A | p.Asp654Asn | p.D654N | | protein_coding | tolerated(0.07) | probably_damaging(0.994) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
WDR6 | deletion | Frame_Shift_Del | | c.1342_1370delAAGGTTGTCCCCATCAACACTCCAACTGC | p.Lys448CysfsTer22 | p.K448Cfs*22 | | protein_coding | | | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
WDR6 | deletion | Frame_Shift_Del | novel | c.226delN | p.Phe76LeufsTer7 | p.F76Lfs*7 | | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |