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Gene: TMEM30A |
Gene summary for TMEM30A |
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Gene information | Species | Human | Gene symbol | TMEM30A | Gene ID | 55754 |
Gene name | transmembrane protein 30A | |
Gene Alias | C6orf67 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NV96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55754 | TMEM30A | LZE2T | Human | Esophagus | ESCC | 2.01e-03 | 3.80e-01 | 0.082 |
55754 | TMEM30A | LZE4T | Human | Esophagus | ESCC | 1.11e-13 | 3.95e-01 | 0.0811 |
55754 | TMEM30A | LZE7T | Human | Esophagus | ESCC | 1.20e-03 | 5.85e-01 | 0.0667 |
55754 | TMEM30A | LZE8T | Human | Esophagus | ESCC | 3.37e-08 | 3.47e-02 | 0.067 |
55754 | TMEM30A | LZE20T | Human | Esophagus | ESCC | 2.02e-05 | 1.27e-01 | 0.0662 |
55754 | TMEM30A | LZE24T | Human | Esophagus | ESCC | 1.31e-15 | 6.09e-01 | 0.0596 |
55754 | TMEM30A | LZE21T | Human | Esophagus | ESCC | 9.15e-04 | 7.20e-02 | 0.0655 |
55754 | TMEM30A | LZE6T | Human | Esophagus | ESCC | 2.45e-03 | 1.92e-01 | 0.0845 |
55754 | TMEM30A | P1T-E | Human | Esophagus | ESCC | 5.06e-07 | 2.98e-01 | 0.0875 |
55754 | TMEM30A | P2T-E | Human | Esophagus | ESCC | 1.92e-33 | 6.57e-01 | 0.1177 |
55754 | TMEM30A | P4T-E | Human | Esophagus | ESCC | 4.09e-20 | 6.67e-01 | 0.1323 |
55754 | TMEM30A | P5T-E | Human | Esophagus | ESCC | 2.83e-16 | 3.70e-01 | 0.1327 |
55754 | TMEM30A | P8T-E | Human | Esophagus | ESCC | 3.52e-40 | 9.84e-01 | 0.0889 |
55754 | TMEM30A | P9T-E | Human | Esophagus | ESCC | 1.06e-07 | 2.12e-01 | 0.1131 |
55754 | TMEM30A | P10T-E | Human | Esophagus | ESCC | 3.91e-35 | 7.01e-01 | 0.116 |
55754 | TMEM30A | P11T-E | Human | Esophagus | ESCC | 1.60e-16 | 9.80e-01 | 0.1426 |
55754 | TMEM30A | P12T-E | Human | Esophagus | ESCC | 1.69e-33 | 7.10e-01 | 0.1122 |
55754 | TMEM30A | P15T-E | Human | Esophagus | ESCC | 3.74e-31 | 9.14e-01 | 0.1149 |
55754 | TMEM30A | P16T-E | Human | Esophagus | ESCC | 2.63e-34 | 7.43e-01 | 0.1153 |
55754 | TMEM30A | P17T-E | Human | Esophagus | ESCC | 8.79e-08 | 5.30e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00708617 | Thyroid | PTC | regulation of protein exit from endoplasmic reticulum | 17/5968 | 27/18723 | 8.67e-04 | 5.30e-03 | 17 |
GO:003238632 | Thyroid | ATC | regulation of intracellular transport | 203/6293 | 337/18723 | 6.16e-24 | 1.85e-21 | 203 |
GO:003315726 | Thyroid | ATC | regulation of intracellular protein transport | 147/6293 | 229/18723 | 2.01e-21 | 4.38e-19 | 147 |
GO:003238825 | Thyroid | ATC | positive regulation of intracellular transport | 131/6293 | 202/18723 | 8.20e-20 | 1.24e-17 | 131 |
GO:009031624 | Thyroid | ATC | positive regulation of intracellular protein transport | 107/6293 | 160/18723 | 6.82e-18 | 7.84e-16 | 107 |
GO:190495128 | Thyroid | ATC | positive regulation of establishment of protein localization | 177/6293 | 319/18723 | 5.43e-16 | 4.29e-14 | 177 |
GO:005122234 | Thyroid | ATC | positive regulation of protein transport | 165/6293 | 303/18723 | 4.94e-14 | 2.69e-12 | 165 |
GO:003134623 | Thyroid | ATC | positive regulation of cell projection organization | 186/6293 | 353/18723 | 7.99e-14 | 4.23e-12 | 186 |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:003252715 | Thyroid | ATC | protein exit from endoplasmic reticulum | 32/6293 | 48/18723 | 2.88e-06 | 3.30e-05 | 32 |
GO:001097614 | Thyroid | ATC | positive regulation of neuron projection development | 82/6293 | 163/18723 | 7.43e-06 | 7.61e-05 | 82 |
GO:007086113 | Thyroid | ATC | regulation of protein exit from endoplasmic reticulum | 17/6293 | 27/18723 | 1.70e-03 | 8.47e-03 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM30A | SNV | Missense_Mutation | novel | c.549A>C | p.Leu183Phe | p.L183F | Q9NV96 | protein_coding | tolerated(0.75) | benign(0.405) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TMEM30A | SNV | Missense_Mutation | rs766839161 | c.808C>T | p.Arg270Cys | p.R270C | Q9NV96 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM30A | SNV | Missense_Mutation | novel | c.149T>G | p.Val50Gly | p.V50G | Q9NV96 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TMEM30A | deletion | Frame_Shift_Del | novel | c.216delN | p.Asn73ThrfsTer27 | p.N73Tfs*27 | Q9NV96 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TMEM30A | SNV | Missense_Mutation | novel | c.14N>G | p.Tyr5Cys | p.Y5C | Q9NV96 | protein_coding | tolerated_low_confidence(0.1) | benign(0.005) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM30A | SNV | Missense_Mutation | c.851C>T | p.Pro284Leu | p.P284L | Q9NV96 | protein_coding | tolerated(0.14) | benign(0.371) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM30A | SNV | Missense_Mutation | c.200N>A | p.Gly67Asp | p.G67D | Q9NV96 | protein_coding | deleterious(0.04) | possibly_damaging(0.829) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TMEM30A | SNV | Missense_Mutation | rs766839161 | c.808C>T | p.Arg270Cys | p.R270C | Q9NV96 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM30A | SNV | Missense_Mutation | rs778890689 | c.920N>A | p.Arg307Gln | p.R307Q | Q9NV96 | protein_coding | tolerated(0.06) | benign(0.393) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM30A | SNV | Missense_Mutation | c.769T>G | p.Phe257Val | p.F257V | Q9NV96 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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