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Gene: STN1 |
Gene summary for STN1 |
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Gene information | Species | Human | Gene symbol | STN1 | Gene ID | 79991 |
Gene name | STN1 subunit of CST complex | |
Gene Alias | AAF-44 | |
Cytomap | 10q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q9H668 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79991 | STN1 | LZE4T | Human | Esophagus | ESCC | 3.78e-08 | 2.32e-01 | 0.0811 |
79991 | STN1 | LZE7T | Human | Esophagus | ESCC | 3.98e-06 | 3.01e-01 | 0.0667 |
79991 | STN1 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.56e-01 | 0.067 |
79991 | STN1 | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 1.97e-01 | 0.0662 |
79991 | STN1 | LZE24T | Human | Esophagus | ESCC | 6.51e-29 | 6.49e-01 | 0.0596 |
79991 | STN1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.06e-01 | 0.0655 |
79991 | STN1 | LZE6T | Human | Esophagus | ESCC | 9.07e-08 | 3.26e-01 | 0.0845 |
79991 | STN1 | NAFLD1 | Human | Liver | NAFLD | 1.48e-02 | 1.88e-01 | -0.04 |
79991 | STN1 | HCC1 | Human | Liver | HCC | 1.89e-02 | 1.43e+00 | 0.5336 |
79991 | STN1 | HCC2 | Human | Liver | HCC | 1.30e-15 | 3.17e+00 | 0.5341 |
79991 | STN1 | S014 | Human | Liver | HCC | 1.36e-21 | 4.67e-01 | 0.2254 |
79991 | STN1 | S015 | Human | Liver | HCC | 6.83e-29 | 7.11e-01 | 0.2375 |
79991 | STN1 | S016 | Human | Liver | HCC | 1.04e-22 | 5.13e-01 | 0.2243 |
79991 | STN1 | S027 | Human | Liver | HCC | 2.89e-15 | 6.94e-01 | 0.2446 |
79991 | STN1 | S028 | Human | Liver | HCC | 5.39e-21 | 5.63e-01 | 0.2503 |
79991 | STN1 | S029 | Human | Liver | HCC | 3.57e-22 | 6.40e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604918 | Oral cavity | LP | cell growth | 155/4623 | 482/18723 | 1.08e-04 | 1.31e-03 | 155 |
GO:009887614 | Oral cavity | LP | vesicle-mediated transport to the plasma membrane | 53/4623 | 136/18723 | 1.54e-04 | 1.76e-03 | 53 |
GO:000155817 | Oral cavity | LP | regulation of cell growth | 134/4623 | 414/18723 | 2.25e-04 | 2.41e-03 | 134 |
GO:004206026 | Oral cavity | EOLP | wound healing | 99/2218 | 422/18723 | 1.18e-11 | 1.85e-09 | 99 |
GO:003109923 | Oral cavity | EOLP | regeneration | 50/2218 | 198/18723 | 1.30e-07 | 4.25e-06 | 50 |
GO:00422462 | Oral cavity | EOLP | tissue regeneration | 22/2218 | 72/18723 | 1.82e-05 | 2.91e-04 | 22 |
GO:00020622 | Oral cavity | EOLP | chondrocyte differentiation | 22/2218 | 106/18723 | 5.93e-03 | 2.98e-02 | 22 |
GO:004206033 | Oral cavity | NEOLP | wound healing | 106/2005 | 422/18723 | 1.93e-17 | 1.91e-14 | 106 |
GO:003109931 | Oral cavity | NEOLP | regeneration | 45/2005 | 198/18723 | 7.52e-07 | 2.10e-05 | 45 |
GO:00614482 | Oral cavity | NEOLP | connective tissue development | 46/2005 | 252/18723 | 2.11e-04 | 2.25e-03 | 46 |
GO:00422463 | Oral cavity | NEOLP | tissue regeneration | 18/2005 | 72/18723 | 4.55e-04 | 4.08e-03 | 18 |
GO:00020621 | Oral cavity | NEOLP | chondrocyte differentiation | 22/2005 | 106/18723 | 1.72e-03 | 1.19e-02 | 22 |
GO:0051216 | Oral cavity | NEOLP | cartilage development | 32/2005 | 190/18723 | 6.44e-03 | 3.32e-02 | 32 |
GO:001604910 | Prostate | BPH | cell growth | 139/3107 | 482/18723 | 7.53e-12 | 5.90e-10 | 139 |
GO:000155810 | Prostate | BPH | regulation of cell growth | 116/3107 | 414/18723 | 2.66e-09 | 1.05e-07 | 116 |
GO:003432910 | Prostate | BPH | cell junction assembly | 114/3107 | 420/18723 | 2.52e-08 | 7.49e-07 | 114 |
GO:199077810 | Prostate | BPH | protein localization to cell periphery | 95/3107 | 333/18723 | 2.78e-08 | 8.13e-07 | 95 |
GO:009015016 | Prostate | BPH | establishment of protein localization to membrane | 77/3107 | 260/18723 | 1.06e-07 | 2.56e-06 | 77 |
GO:19018888 | Prostate | BPH | regulation of cell junction assembly | 62/3107 | 204/18723 | 6.71e-07 | 1.30e-05 | 62 |
GO:00988768 | Prostate | BPH | vesicle-mediated transport to the plasma membrane | 43/3107 | 136/18723 | 1.11e-05 | 1.51e-04 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STN1 | SNV | Missense_Mutation | rs146909879 | c.149A>G | p.Asn50Ser | p.N50S | Q9H668 | protein_coding | deleterious(0.02) | probably_damaging(0.918) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
STN1 | SNV | Missense_Mutation | c.542N>A | p.Pro181His | p.P181H | Q9H668 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STN1 | SNV | Missense_Mutation | c.284N>G | p.Glu95Gly | p.E95G | Q9H668 | protein_coding | tolerated(0.28) | benign(0.096) | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
STN1 | SNV | Missense_Mutation | c.487C>G | p.Gln163Glu | p.Q163E | Q9H668 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
STN1 | deletion | Frame_Shift_Del | c.990_999delNNNNNNNNNN | p.Cys330Ter | p.C330* | Q9H668 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |||
STN1 | SNV | Missense_Mutation | novel | c.290T>C | p.Val97Ala | p.V97A | Q9H668 | protein_coding | tolerated(0.77) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STN1 | SNV | Missense_Mutation | rs183917764 | c.416N>A | p.Arg139His | p.R139H | Q9H668 | protein_coding | tolerated(0.12) | benign(0.168) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STN1 | SNV | Missense_Mutation | c.949N>T | p.His317Tyr | p.H317Y | Q9H668 | protein_coding | tolerated(0.35) | benign(0.013) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STN1 | SNV | Missense_Mutation | rs780655414 | c.1010C>T | p.Pro337Leu | p.P337L | Q9H668 | protein_coding | tolerated(0.52) | possibly_damaging(0.47) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STN1 | deletion | Frame_Shift_Del | c.831delN | p.Gly278AspfsTer16 | p.G278Dfs*16 | Q9H668 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79991 | STN1 | ENZYME | atenolol | ATENOLOL | 31327267 |
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