Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SPTAN1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SPTAN1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SPTAN1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SPTAN1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SPTAN1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SPTAN1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SPTAN1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SPTAN1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SPTAN1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SPTAN1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00308324 | Colorectum | FAP | regulation of actin filament length | 52/2622 | 189/18723 | 7.91e-07 | 3.64e-05 | 52 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00106393 | Colorectum | FAP | negative regulation of organelle organization | 80/2622 | 348/18723 | 3.62e-06 | 1.27e-04 | 80 |
GO:00329844 | Colorectum | FAP | protein-containing complex disassembly | 54/2622 | 224/18723 | 3.37e-05 | 7.48e-04 | 54 |
GO:00300423 | Colorectum | FAP | actin filament depolymerization | 19/2622 | 59/18723 | 2.87e-04 | 3.77e-03 | 19 |
GO:00308373 | Colorectum | FAP | negative regulation of actin filament polymerization | 20/2622 | 65/18723 | 3.95e-04 | 4.83e-03 | 20 |
GO:00313334 | Colorectum | FAP | negative regulation of protein-containing complex assembly | 35/2622 | 141/18723 | 4.25e-04 | 5.10e-03 | 35 |
GO:00322724 | Colorectum | FAP | negative regulation of protein polymerization | 23/2622 | 80/18723 | 4.51e-04 | 5.32e-03 | 23 |
GO:19029043 | Colorectum | FAP | negative regulation of supramolecular fiber organization | 38/2622 | 167/18723 | 1.47e-03 | 1.31e-02 | 38 |
GO:00514943 | Colorectum | FAP | negative regulation of cytoskeleton organization | 37/2622 | 163/18723 | 1.76e-03 | 1.53e-02 | 37 |
GO:00308343 | Colorectum | FAP | regulation of actin filament depolymerization | 16/2622 | 54/18723 | 2.26e-03 | 1.84e-02 | 16 |
GO:00308353 | Colorectum | FAP | negative regulation of actin filament depolymerization | 14/2622 | 45/18723 | 2.53e-03 | 1.99e-02 | 14 |
GO:00516933 | Colorectum | FAP | actin filament capping | 13/2622 | 41/18723 | 2.96e-03 | 2.25e-02 | 13 |
GO:00432442 | Colorectum | FAP | regulation of protein-containing complex disassembly | 28/2622 | 121/18723 | 4.50e-03 | 3.06e-02 | 28 |
GO:00512612 | Colorectum | FAP | protein depolymerization | 26/2622 | 114/18723 | 7.36e-03 | 4.40e-02 | 26 |
GO:00432421 | Colorectum | FAP | negative regulation of protein-containing complex disassembly | 20/2622 | 82/18723 | 8.23e-03 | 4.82e-02 | 20 |
GO:00070155 | Colorectum | CRC | actin filament organization | 104/2078 | 442/18723 | 4.75e-14 | 7.12e-11 | 104 |
GO:00329705 | Colorectum | CRC | regulation of actin filament-based process | 89/2078 | 397/18723 | 5.25e-11 | 3.14e-08 | 89 |
GO:00432545 | Colorectum | CRC | regulation of protein-containing complex assembly | 87/2078 | 428/18723 | 1.38e-08 | 2.67e-06 | 87 |
GO:19029035 | Colorectum | CRC | regulation of supramolecular fiber organization | 80/2078 | 383/18723 | 1.52e-08 | 2.75e-06 | 80 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPTAN1 | SNV | Missense_Mutation | | c.4690N>C | p.Glu1564Gln | p.E1564Q | Q13813 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
SPTAN1 | SNV | Missense_Mutation | rs770133448 | c.5524N>A | p.Gly1842Arg | p.G1842R | Q13813 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A0T1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | herceptin | SD |
SPTAN1 | SNV | Missense_Mutation | novel | c.6932N>G | p.His2311Arg | p.H2311R | Q13813 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-A2-A3XY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
SPTAN1 | SNV | Missense_Mutation | | c.2053N>T | p.Arg685Cys | p.R685C | Q13813 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A7-A13E-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | bevacizumab | PD |
SPTAN1 | SNV | Missense_Mutation | | c.2371N>T | p.Arg791Trp | p.R791W | Q13813 | protein_coding | deleterious(0) | possibly_damaging(0.599) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPTAN1 | SNV | Missense_Mutation | | c.4698N>C | p.Trp1566Cys | p.W1566C | Q13813 | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPTAN1 | SNV | Missense_Mutation | novel | c.4259N>G | p.Leu1420Arg | p.L1420R | Q13813 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPTAN1 | SNV | Missense_Mutation | | c.4967N>A | p.Ser1656Asn | p.S1656N | Q13813 | protein_coding | tolerated(0.2) | probably_damaging(0.916) | TCGA-AR-A254-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SPTAN1 | SNV | Missense_Mutation | novel | c.4968N>G | p.Ser1656Arg | p.S1656R | Q13813 | protein_coding | tolerated(0.11) | probably_damaging(0.975) | TCGA-AR-A254-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SPTAN1 | SNV | Missense_Mutation | novel | c.5353A>G | p.Ile1785Val | p.I1785V | Q13813 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR |