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Gene: SORBS3 |
Gene summary for SORBS3 |
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Gene information | Species | Human | Gene symbol | SORBS3 | Gene ID | 10174 |
Gene name | sorbin and SH3 domain containing 3 | |
Gene Alias | SCAM-1 | |
Cytomap | 8p21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O60504 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10174 | SORBS3 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.23e-05 | 2.45e-01 | -0.1954 |
10174 | SORBS3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.30e-03 | 2.45e-01 | -0.1207 |
10174 | SORBS3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.37e-07 | 3.13e-01 | -0.1001 |
10174 | SORBS3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.06e-05 | 4.11e-01 | -0.1706 |
10174 | SORBS3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.45e-06 | 3.22e-01 | 0.0674 |
10174 | SORBS3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.84e-03 | 3.94e-01 | 0.0112 |
10174 | SORBS3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.09e-08 | 4.14e-01 | 0.0588 |
10174 | SORBS3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.46e-03 | 2.66e-01 | 0.2585 |
10174 | SORBS3 | LZE4T | Human | Esophagus | ESCC | 1.51e-12 | 2.64e-01 | 0.0811 |
10174 | SORBS3 | LZE8T | Human | Esophagus | ESCC | 6.54e-04 | 3.11e-02 | 0.067 |
10174 | SORBS3 | LZE24T | Human | Esophagus | ESCC | 3.67e-23 | 7.82e-01 | 0.0596 |
10174 | SORBS3 | LZE21T | Human | Esophagus | ESCC | 8.10e-04 | 2.62e-01 | 0.0655 |
10174 | SORBS3 | P1T-E | Human | Esophagus | ESCC | 6.70e-05 | 5.31e-01 | 0.0875 |
10174 | SORBS3 | P2T-E | Human | Esophagus | ESCC | 1.17e-84 | 1.31e+00 | 0.1177 |
10174 | SORBS3 | P4T-E | Human | Esophagus | ESCC | 5.34e-45 | 1.12e+00 | 0.1323 |
10174 | SORBS3 | P5T-E | Human | Esophagus | ESCC | 8.21e-16 | 4.10e-01 | 0.1327 |
10174 | SORBS3 | P8T-E | Human | Esophagus | ESCC | 7.17e-56 | 9.84e-01 | 0.0889 |
10174 | SORBS3 | P9T-E | Human | Esophagus | ESCC | 5.62e-18 | 5.91e-01 | 0.1131 |
10174 | SORBS3 | P10T-E | Human | Esophagus | ESCC | 2.62e-70 | 1.20e+00 | 0.116 |
10174 | SORBS3 | P11T-E | Human | Esophagus | ESCC | 2.01e-17 | 7.12e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003295633 | Oral cavity | NEOLP | regulation of actin cytoskeleton organization | 77/2005 | 358/18723 | 1.51e-09 | 1.02e-07 | 77 |
GO:011005333 | Oral cavity | NEOLP | regulation of actin filament organization | 60/2005 | 278/18723 | 8.37e-08 | 3.17e-06 | 60 |
GO:005149532 | Oral cavity | NEOLP | positive regulation of cytoskeleton organization | 50/2005 | 226/18723 | 4.47e-07 | 1.35e-05 | 50 |
GO:003103224 | Oral cavity | NEOLP | actomyosin structure organization | 44/2005 | 196/18723 | 1.42e-06 | 3.58e-05 | 44 |
GO:005101733 | Oral cavity | NEOLP | actin filament bundle assembly | 36/2005 | 157/18723 | 7.50e-06 | 1.48e-04 | 36 |
GO:006157226 | Oral cavity | NEOLP | actin filament bundle organization | 36/2005 | 161/18723 | 1.36e-05 | 2.41e-04 | 36 |
GO:003003825 | Oral cavity | NEOLP | contractile actin filament bundle assembly | 26/2005 | 106/18723 | 3.95e-05 | 5.62e-04 | 26 |
GO:004314925 | Oral cavity | NEOLP | stress fiber assembly | 26/2005 | 106/18723 | 3.95e-05 | 5.62e-04 | 26 |
GO:005149224 | Oral cavity | NEOLP | regulation of stress fiber assembly | 22/2005 | 91/18723 | 1.89e-04 | 2.05e-03 | 22 |
GO:0110020110 | Oral cavity | NEOLP | regulation of actomyosin structure organization | 23/2005 | 100/18723 | 3.00e-04 | 2.97e-03 | 23 |
GO:003223125 | Oral cavity | NEOLP | regulation of actin filament bundle assembly | 23/2005 | 105/18723 | 6.28e-04 | 5.38e-03 | 23 |
GO:004341013 | Oral cavity | NEOLP | positive regulation of MAPK cascade | 70/2005 | 480/18723 | 4.59e-03 | 2.56e-02 | 70 |
GO:003223318 | Oral cavity | NEOLP | positive regulation of actin filament bundle assembly | 14/2005 | 63/18723 | 5.98e-03 | 3.11e-02 | 14 |
GO:005149614 | Oral cavity | NEOLP | positive regulation of stress fiber assembly | 12/2005 | 52/18723 | 7.72e-03 | 3.84e-02 | 12 |
GO:190290329 | Skin | cSCC | regulation of supramolecular fiber organization | 145/4864 | 383/18723 | 1.67e-07 | 3.71e-06 | 145 |
GO:000701529 | Skin | cSCC | actin filament organization | 156/4864 | 442/18723 | 7.37e-06 | 1.02e-04 | 156 |
GO:003297029 | Skin | cSCC | regulation of actin filament-based process | 142/4864 | 397/18723 | 8.50e-06 | 1.13e-04 | 142 |
GO:1902905112 | Skin | cSCC | positive regulation of supramolecular fiber organization | 83/4864 | 209/18723 | 8.87e-06 | 1.17e-04 | 83 |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:0110053111 | Skin | cSCC | regulation of actin filament organization | 103/4864 | 278/18723 | 2.78e-05 | 3.12e-04 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SORBS3 | SNV | Missense_Mutation | c.1640C>T | p.Ser547Leu | p.S547L | O60504 | protein_coding | tolerated(0.79) | benign(0.003) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SORBS3 | SNV | Missense_Mutation | c.572C>A | p.Thr191Lys | p.T191K | O60504 | protein_coding | tolerated(0.35) | benign(0) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SORBS3 | SNV | Missense_Mutation | novel | c.689N>A | p.Arg230Gln | p.R230Q | O60504 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
SORBS3 | deletion | Frame_Shift_Del | novel | c.1333delN | p.Ile446SerfsTer38 | p.I446Sfs*38 | O60504 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SORBS3 | SNV | Missense_Mutation | c.554N>G | p.His185Arg | p.H185R | O60504 | protein_coding | tolerated(0.54) | benign(0) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SORBS3 | SNV | Missense_Mutation | novel | c.103G>T | p.Val35Leu | p.V35L | O60504 | protein_coding | deleterious(0.01) | benign(0.034) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SORBS3 | SNV | Missense_Mutation | novel | c.1903N>C | p.Glu635Gln | p.E635Q | O60504 | protein_coding | deleterious(0.04) | benign(0.342) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SORBS3 | SNV | Missense_Mutation | rs375539049 | c.161C>T | p.Ala54Val | p.A54V | O60504 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SORBS3 | SNV | Missense_Mutation | rs775458853 | c.1484G>A | p.Arg495His | p.R495H | O60504 | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SORBS3 | SNV | Missense_Mutation | novel | c.865N>A | p.Asp289Asn | p.D289N | O60504 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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