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Gene: SNX17 |
Gene summary for SNX17 |
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Gene information | Species | Human | Gene symbol | SNX17 | Gene ID | 9784 |
Gene name | sorting nexin 17 | |
Gene Alias | SNX17 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0001568 | UniProtAcc | B4DTB8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9784 | SNX17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.73e-06 | 3.40e-01 | -0.1808 |
9784 | SNX17 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.87e-06 | 3.27e-01 | -0.0811 |
9784 | SNX17 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.70e-05 | 2.94e-01 | -0.1088 |
9784 | SNX17 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.86e-11 | 3.28e-01 | -0.1954 |
9784 | SNX17 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.33e-07 | 3.55e-01 | -0.1207 |
9784 | SNX17 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.26e-02 | 1.94e-01 | -0.1526 |
9784 | SNX17 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.53e-12 | 2.63e-01 | -0.1464 |
9784 | SNX17 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.62e-04 | 1.73e-01 | -0.1001 |
9784 | SNX17 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.66e-12 | 4.02e-01 | -0.059 |
9784 | SNX17 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.00e-04 | 3.18e-01 | -0.2061 |
9784 | SNX17 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.86e-13 | 3.61e-01 | 0.096 |
9784 | SNX17 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.76e-02 | 2.63e-01 | 0.0528 |
9784 | SNX17 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.53e-02 | 3.35e-01 | 0.0131 |
9784 | SNX17 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.76e-04 | 3.29e-01 | -0.0177 |
9784 | SNX17 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.13e-02 | 2.34e-01 | 0.0338 |
9784 | SNX17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.74e-08 | 2.10e-01 | 0.0674 |
9784 | SNX17 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.67e-09 | 3.43e-01 | 0.294 |
9784 | SNX17 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.01e-11 | 5.31e-01 | 0.281 |
9784 | SNX17 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.01e-11 | 3.17e-01 | 0.3859 |
9784 | SNX17 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.10e-07 | 4.47e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000689826 | Thyroid | ATC | receptor-mediated endocytosis | 118/6293 | 244/18723 | 1.17e-06 | 1.50e-05 | 118 |
GO:000327912 | Thyroid | ATC | cardiac septum development | 56/6293 | 103/18723 | 1.14e-05 | 1.11e-04 | 56 |
GO:000320512 | Thyroid | ATC | cardiac chamber development | 79/6293 | 161/18723 | 3.39e-05 | 2.80e-04 | 79 |
GO:00608401 | Thyroid | ATC | artery development | 48/6293 | 100/18723 | 1.97e-03 | 9.52e-03 | 48 |
GO:0035904 | Thyroid | ATC | aorta development | 30/6293 | 58/18723 | 3.31e-03 | 1.48e-02 | 30 |
GO:0060976 | Thyroid | ATC | coronary vasculature development | 24/6293 | 46/18723 | 7.13e-03 | 2.82e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX17 | SNV | Missense_Mutation | rs756756686 | c.827N>T | p.Ala276Val | p.A276V | Q15036 | protein_coding | deleterious(0) | benign(0.043) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SNX17 | SNV | Missense_Mutation | rs747689756 | c.708N>T | p.Trp236Cys | p.W236C | Q15036 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SNX17 | SNV | Missense_Mutation | c.1034N>A | p.Arg345His | p.R345H | Q15036 | protein_coding | tolerated(0.1) | benign(0.006) | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
SNX17 | SNV | Missense_Mutation | novel | c.954N>A | p.Met318Ile | p.M318I | Q15036 | protein_coding | tolerated(0.24) | benign(0.134) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
SNX17 | SNV | Missense_Mutation | c.1054N>A | p.Tyr352Asn | p.Y352N | Q15036 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A1LL-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
SNX17 | SNV | Missense_Mutation | novel | c.968T>G | p.Val323Gly | p.V323G | Q15036 | protein_coding | deleterious(0) | possibly_damaging(0.536) | TCGA-OL-A6VO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SNX17 | insertion | In_Frame_Ins | novel | c.281_282insTGGTTTTCTGTCCAGTCTTACTGCTCTAGTAGCCTTTAC | p.Ser94_Ser95insGlyPheLeuSerSerLeuThrAlaLeuValAlaPheThr | p.S94_S95insGFLSSLTALVAFT | Q15036 | protein_coding | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
SNX17 | insertion | Frame_Shift_Ins | novel | c.1390_1391insACCTGAT | p.Gly464AspfsTer7 | p.G464Dfs*7 | Q15036 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
SNX17 | insertion | Frame_Shift_Ins | novel | c.1392_1393insCACCCGGGAGTCTATGGTCAAACTCTCAGTG | p.Ile465HisfsTer14 | p.I465Hfs*14 | Q15036 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
SNX17 | insertion | Nonsense_Mutation | novel | c.142_143insCCAGATCTTAAACTCTATTTAACTCA | p.Arg48ProfsTer4 | p.R48Pfs*4 | Q15036 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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