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Gene: SIRT7 |
Gene summary for SIRT7 |
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Gene information | Species | Human | Gene symbol | SIRT7 | Gene ID | 51547 |
Gene name | sirtuin 7 | |
Gene Alias | SIR2L7 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NRC8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51547 | SIRT7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.30e-08 | 5.58e-01 | -0.1808 |
51547 | SIRT7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.56e-03 | 2.61e-01 | -0.0811 |
51547 | SIRT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.59e-07 | 3.09e-01 | -0.1954 |
51547 | SIRT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.38e-03 | 7.64e-01 | -0.2602 |
51547 | SIRT7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.85e-03 | 5.89e-01 | -0.2196 |
51547 | SIRT7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.34e-05 | 4.13e-01 | -0.1526 |
51547 | SIRT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.69e-04 | 3.39e-01 | -0.1464 |
51547 | SIRT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.74e-04 | 2.47e-01 | -0.1001 |
51547 | SIRT7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.43e-07 | 3.17e-01 | -0.059 |
51547 | SIRT7 | A002-C-205 | Human | Colorectum | FAP | 1.15e-02 | -1.40e-01 | -0.1236 |
51547 | SIRT7 | A002-C-116 | Human | Colorectum | FAP | 7.37e-03 | -1.05e-01 | -0.0452 |
51547 | SIRT7 | LZE2T | Human | Esophagus | ESCC | 2.02e-02 | 3.72e-01 | 0.082 |
51547 | SIRT7 | LZE7T | Human | Esophagus | ESCC | 2.59e-09 | 3.56e-01 | 0.0667 |
51547 | SIRT7 | LZE20T | Human | Esophagus | ESCC | 1.04e-05 | 2.18e-01 | 0.0662 |
51547 | SIRT7 | LZE22T | Human | Esophagus | ESCC | 2.78e-14 | 5.42e-01 | 0.068 |
51547 | SIRT7 | LZE24T | Human | Esophagus | ESCC | 4.83e-34 | 7.81e-01 | 0.0596 |
51547 | SIRT7 | LZE21T | Human | Esophagus | ESCC | 5.65e-10 | 6.14e-01 | 0.0655 |
51547 | SIRT7 | P1T-E | Human | Esophagus | ESCC | 7.67e-22 | 6.81e-01 | 0.0875 |
51547 | SIRT7 | P2T-E | Human | Esophagus | ESCC | 1.36e-15 | 2.79e-01 | 0.1177 |
51547 | SIRT7 | P4T-E | Human | Esophagus | ESCC | 6.07e-18 | 3.66e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20007793 | Esophagus | ESCC | regulation of double-strand break repair | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
GO:00060943 | Esophagus | ESCC | gluconeogenesis | 46/8552 | 75/18723 | 4.54e-03 | 1.78e-02 | 46 |
GO:2000234 | Esophagus | ESCC | positive regulation of rRNA processing | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:19018361 | Esophagus | ESCC | regulation of transcription of nucleolar large rRNA by RNA polymerase I | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:00709321 | Esophagus | ESCC | histone H3 deacetylation | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:003238611 | Liver | Cirrhotic | regulation of intracellular transport | 147/4634 | 337/18723 | 1.84e-14 | 1.72e-12 | 147 |
GO:003315711 | Liver | Cirrhotic | regulation of intracellular protein transport | 108/4634 | 229/18723 | 1.23e-13 | 1.04e-11 | 108 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:003139612 | Liver | Cirrhotic | regulation of protein ubiquitination | 89/4634 | 210/18723 | 1.40e-08 | 5.30e-07 | 89 |
GO:000691312 | Liver | Cirrhotic | nucleocytoplasmic transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116912 | Liver | Cirrhotic | nuclear transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:000599612 | Liver | Cirrhotic | monosaccharide metabolic process | 104/4634 | 257/18723 | 1.74e-08 | 6.32e-07 | 104 |
GO:001931812 | Liver | Cirrhotic | hexose metabolic process | 97/4634 | 237/18723 | 2.67e-08 | 9.16e-07 | 97 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIRT7 | SNV | Missense_Mutation | c.1076C>G | p.Ser359Trp | p.S359W | Q9NRC8 | protein_coding | tolerated(0.18) | possibly_damaging(0.652) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SIRT7 | SNV | Missense_Mutation | c.1191N>C | p.Lys397Asn | p.K397N | Q9NRC8 | protein_coding | deleterious_low_confidence(0) | benign(0.092) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIRT7 | SNV | Missense_Mutation | novel | c.710T>C | p.Val237Ala | p.V237A | Q9NRC8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
SIRT7 | SNV | Missense_Mutation | rs781471662 | c.1042C>T | p.Arg348Cys | p.R348C | Q9NRC8 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
SIRT7 | SNV | Missense_Mutation | rs757485586 | c.1043G>A | p.Arg348His | p.R348H | Q9NRC8 | protein_coding | tolerated(0.09) | benign(0.018) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT7 | SNV | Missense_Mutation | novel | c.1185N>C | p.Lys395Asn | p.K395N | Q9NRC8 | protein_coding | deleterious_low_confidence(0.01) | benign(0.436) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SIRT7 | SNV | Missense_Mutation | rs200982525 | c.952G>A | p.Val318Ile | p.V318I | Q9NRC8 | protein_coding | deleterious(0.03) | possibly_damaging(0.459) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SIRT7 | SNV | Missense_Mutation | rs190336639 | c.994N>A | p.Ala332Thr | p.A332T | Q9NRC8 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SIRT7 | SNV | Missense_Mutation | rs747584480 | c.1031N>T | p.Ala344Val | p.A344V | Q9NRC8 | protein_coding | deleterious(0.02) | benign(0.352) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIRT7 | SNV | Missense_Mutation | c.941A>C | p.Lys314Thr | p.K314T | Q9NRC8 | protein_coding | deleterious(0) | benign(0.265) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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