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Gene: SIK1 |
Gene summary for SIK1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SIK1 | Gene ID | 150094 |
| Gene name | salt inducible kinase 1 | |
| Gene Alias | DEE30 | |
| Cytomap | 21q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P57059 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 150094 | SIK1 | P5T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.16e-01 | 0.1327 |
| 150094 | SIK1 | P9T-E | Human | Esophagus | ESCC | 1.23e-14 | 3.26e-01 | 0.1131 |
| 150094 | SIK1 | P11T-E | Human | Esophagus | ESCC | 3.66e-11 | 5.38e-01 | 0.1426 |
| 150094 | SIK1 | P12T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.48e-02 | 0.1122 |
| 150094 | SIK1 | P22T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.24e-01 | 0.1236 |
| 150094 | SIK1 | P23T-E | Human | Esophagus | ESCC | 3.88e-04 | 1.49e-01 | 0.108 |
| 150094 | SIK1 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.28e-01 | 0.1055 |
| 150094 | SIK1 | P30T-E | Human | Esophagus | ESCC | 1.44e-32 | 9.69e-01 | 0.137 |
| 150094 | SIK1 | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.08e-01 | 0.1187 |
| 150094 | SIK1 | P37T-E | Human | Esophagus | ESCC | 3.92e-24 | 4.86e-01 | 0.1371 |
| 150094 | SIK1 | P47T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.86e-01 | 0.1067 |
| 150094 | SIK1 | P49T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.14e-01 | 0.1768 |
| 150094 | SIK1 | P57T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.21e-02 | 0.0926 |
| 150094 | SIK1 | P62T-E | Human | Esophagus | ESCC | 2.13e-09 | 1.99e-01 | 0.1302 |
| 150094 | SIK1 | P65T-E | Human | Esophagus | ESCC | 6.43e-06 | 1.45e-01 | 0.0978 |
| 150094 | SIK1 | P76T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.69e-01 | 0.1207 |
| 150094 | SIK1 | P80T-E | Human | Esophagus | ESCC | 3.16e-03 | 1.31e-01 | 0.155 |
| 150094 | SIK1 | P94T-E | Human | Esophagus | ESCC | 6.05e-03 | 2.95e-01 | 0.0879 |
| 150094 | SIK1 | P126T-E | Human | Esophagus | ESCC | 7.86e-04 | 2.76e-01 | 0.1125 |
| 150094 | SIK1 | P127T-E | Human | Esophagus | ESCC | 3.68e-10 | 2.11e-01 | 0.0826 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0046890 | Stomach | GC | regulation of lipid biosynthetic process | 22/1159 | 171/18723 | 8.94e-04 | 1.10e-02 | 22 |
| GO:0019432 | Stomach | GC | triglyceride biosynthetic process | 9/1159 | 42/18723 | 9.01e-04 | 1.11e-02 | 9 |
| GO:00060064 | Stomach | GC | glucose metabolic process | 23/1159 | 196/18723 | 2.39e-03 | 2.29e-02 | 23 |
| GO:00425944 | Stomach | GC | response to starvation | 23/1159 | 197/18723 | 2.55e-03 | 2.39e-02 | 23 |
| GO:00316685 | Stomach | GC | cellular response to extracellular stimulus | 27/1159 | 246/18723 | 2.79e-03 | 2.55e-02 | 27 |
| GO:2000209 | Stomach | GC | regulation of anoikis | 6/1159 | 24/18723 | 2.85e-03 | 2.58e-02 | 6 |
| GO:00092674 | Stomach | GC | cellular response to starvation | 19/1159 | 156/18723 | 3.63e-03 | 3.09e-02 | 19 |
| GO:00316694 | Stomach | GC | cellular response to nutrient levels | 24/1159 | 215/18723 | 3.74e-03 | 3.18e-02 | 24 |
| GO:00464862 | Stomach | GC | glycerolipid metabolic process | 38/1159 | 392/18723 | 4.15e-03 | 3.47e-02 | 38 |
| GO:0009649 | Stomach | GC | entrainment of circadian clock | 7/1159 | 34/18723 | 4.21e-03 | 3.49e-02 | 7 |
| GO:00109594 | Stomach | GC | regulation of metal ion transport | 39/1159 | 406/18723 | 4.34e-03 | 3.58e-02 | 39 |
| GO:00076235 | Stomach | GC | circadian rhythm | 23/1159 | 210/18723 | 5.64e-03 | 4.34e-02 | 23 |
| GO:003166731 | Stomach | CAG | response to nutrient levels | 32/552 | 474/18723 | 1.28e-05 | 5.12e-04 | 32 |
| GO:00093143 | Stomach | CAG | response to radiation | 31/552 | 456/18723 | 1.53e-05 | 5.84e-04 | 31 |
| GO:00109593 | Stomach | CAG | regulation of metal ion transport | 23/552 | 406/18723 | 2.26e-03 | 2.50e-02 | 23 |
| GO:0009416 | Stomach | CAG | response to light stimulus | 19/552 | 320/18723 | 3.17e-03 | 3.09e-02 | 19 |
| GO:007149631 | Stomach | CAG | cellular response to external stimulus | 19/552 | 320/18723 | 3.17e-03 | 3.09e-02 | 19 |
| GO:003166911 | Stomach | CAG | cellular response to nutrient levels | 14/552 | 215/18723 | 4.79e-03 | 4.18e-02 | 14 |
| GO:00316674 | Stomach | WIM | response to nutrient levels | 31/426 | 474/18723 | 1.54e-07 | 1.46e-05 | 31 |
| GO:00714964 | Stomach | WIM | cellular response to external stimulus | 21/426 | 320/18723 | 1.52e-05 | 6.48e-04 | 21 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565818 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 178102336 | BOSUTINIB | |
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565729 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 340590212 | ||
| 150094 | SIK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 178102305 | DASATINIB |
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