![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SIGMAR1 |
Gene summary for SIGMAR1 |
![]() |
Gene information | Species | Human | Gene symbol | SIGMAR1 | Gene ID | 10280 |
Gene name | sigma non-opioid intracellular receptor 1 | |
Gene Alias | ALS16 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | B4DR71 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10280 | SIGMAR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.56e-12 | 2.46e-01 | 0.0155 |
10280 | SIGMAR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.97e-06 | 3.01e-01 | -0.1808 |
10280 | SIGMAR1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.44e-02 | 3.66e-01 | 0.0216 |
10280 | SIGMAR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.03e-12 | 5.21e-01 | -0.0811 |
10280 | SIGMAR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.49e-06 | 2.04e-01 | -0.1088 |
10280 | SIGMAR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.31e-16 | 3.53e-01 | -0.1954 |
10280 | SIGMAR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.52e-08 | 6.95e-01 | -0.2602 |
10280 | SIGMAR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-02 | 4.84e-01 | -0.2196 |
10280 | SIGMAR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.29e-04 | 3.16e-01 | -0.1207 |
10280 | SIGMAR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.05e-04 | 3.72e-01 | -0.1526 |
10280 | SIGMAR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.59e-13 | 4.15e-01 | -0.1464 |
10280 | SIGMAR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.02e-06 | 2.62e-01 | -0.1001 |
10280 | SIGMAR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.41e-19 | 6.79e-01 | -0.059 |
10280 | SIGMAR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.22e-03 | 3.77e-01 | -0.1706 |
10280 | SIGMAR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.49e-03 | 3.39e-01 | -0.2061 |
10280 | SIGMAR1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.82e-04 | 3.39e-01 | -0.1462 |
10280 | SIGMAR1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.87e-06 | 2.66e-01 | -0.0842 |
10280 | SIGMAR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.30e-09 | 4.44e-01 | -0.0179 |
10280 | SIGMAR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.99e-25 | 6.17e-01 | 0.096 |
10280 | SIGMAR1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.52e-05 | 4.91e-01 | 0.0446 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004254233 | Thyroid | ATC | response to hydrogen peroxide | 92/6293 | 146/18723 | 3.12e-13 | 1.46e-11 | 92 |
GO:0070997210 | Thyroid | ATC | neuron death | 176/6293 | 361/18723 | 1.43e-09 | 3.57e-08 | 176 |
GO:003461433 | Thyroid | ATC | cellular response to reactive oxygen species | 87/6293 | 155/18723 | 6.54e-09 | 1.43e-07 | 87 |
GO:190121428 | Thyroid | ATC | regulation of neuron death | 156/6293 | 319/18723 | 9.30e-09 | 1.96e-07 | 156 |
GO:007030122 | Thyroid | ATC | cellular response to hydrogen peroxide | 58/6293 | 98/18723 | 1.81e-07 | 2.86e-06 | 58 |
GO:005140227 | Thyroid | ATC | neuron apoptotic process | 120/6293 | 246/18723 | 5.41e-07 | 7.75e-06 | 120 |
GO:004352323 | Thyroid | ATC | regulation of neuron apoptotic process | 104/6293 | 212/18723 | 2.16e-06 | 2.58e-05 | 104 |
GO:003647326 | Thyroid | ATC | cell death in response to oxidative stress | 49/6293 | 95/18723 | 2.23e-04 | 1.46e-03 | 49 |
GO:0036474 | Thyroid | ATC | cell death in response to hydrogen peroxide | 17/6293 | 31/18723 | 1.21e-02 | 4.27e-02 | 17 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050224 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050225 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050146 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050226 | Colorectum | MSI-H | Pathways of neurodegeneration - multiple diseases | 107/797 | 476/8465 | 1.24e-18 | 5.72e-17 | 4.80e-17 | 107 |
hsa050147 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050227 | Colorectum | MSI-H | Pathways of neurodegeneration - multiple diseases | 107/797 | 476/8465 | 1.24e-18 | 5.72e-17 | 4.80e-17 | 107 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIGMAR1 | SNV | Missense_Mutation | rs376256711 | c.524N>A | p.Arg175Gln | p.R175Q | Q99720 | protein_coding | tolerated(0.06) | possibly_damaging(0.799) | TCGA-E2-A15R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
SIGMAR1 | SNV | Missense_Mutation | c.338N>G | p.Ser113Cys | p.S113C | Q99720 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
SIGMAR1 | SNV | Missense_Mutation | novel | c.121N>C | p.Glu41Gln | p.E41Q | Q99720 | protein_coding | tolerated(0.3) | possibly_damaging(0.611) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIGMAR1 | SNV | Missense_Mutation | novel | c.118N>A | p.Glu40Lys | p.E40K | Q99720 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SIGMAR1 | SNV | Missense_Mutation | novel | c.355C>T | p.Arg119Cys | p.R119C | Q99720 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIGMAR1 | SNV | Missense_Mutation | rs755288111 | c.562N>A | p.Asp188Asn | p.D188N | Q99720 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SIGMAR1 | SNV | Missense_Mutation | c.628N>T | p.Leu210Phe | p.L210F | Q99720 | protein_coding | tolerated(0.12) | probably_damaging(0.951) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
SIGMAR1 | SNV | Missense_Mutation | c.626N>A | p.Gly209Asp | p.G209D | Q99720 | protein_coding | deleterious(0.01) | possibly_damaging(0.499) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SIGMAR1 | SNV | Missense_Mutation | rs149409262 | c.529N>A | p.Val177Ile | p.V177I | Q99720 | protein_coding | tolerated(0.08) | benign(0.081) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SIGMAR1 | SNV | Missense_Mutation | rs777650644 | c.553N>A | p.Ala185Thr | p.A185T | Q99720 | protein_coding | tolerated(0.08) | benign(0.164) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | antagonist | 178103764 | FLUVOXAMINE | |
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | SSR-125329A | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | OPC-14523 | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | (+)-[3H]-PENTAZOCINE | CHEMBL2311194 | 22853801 | |
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | Isoindoline derivative 1 | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | Isoindoline derivative 2 | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | SSR-125047 | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | antagonist | 385612191 | ||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | ANAVEX 2-73 | |||
10280 | SIGMAR1 | DRUGGABLE GENOME, ION CHANNEL | Benzamide derivative 11 |
Page: 1 2 3 4 5 6 7 |