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Gene: SELENOK |
Gene summary for SELENOK |
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Gene information | Species | Human | Gene symbol | SELENOK | Gene ID | 58515 |
Gene name | selenoprotein K | |
Gene Alias | HSPC030 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9Y6D0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58515 | SELENOK | GSM4909281 | Human | Breast | IDC | 5.58e-16 | 5.46e-01 | 0.21 |
58515 | SELENOK | GSM4909285 | Human | Breast | IDC | 4.55e-05 | 1.21e-01 | 0.21 |
58515 | SELENOK | GSM4909286 | Human | Breast | IDC | 1.45e-15 | 1.67e-01 | 0.1081 |
58515 | SELENOK | GSM4909290 | Human | Breast | IDC | 7.34e-11 | 3.76e-01 | 0.2096 |
58515 | SELENOK | GSM4909298 | Human | Breast | IDC | 1.90e-14 | 3.08e-01 | 0.1551 |
58515 | SELENOK | GSM4909299 | Human | Breast | IDC | 2.07e-04 | 3.12e-01 | 0.035 |
58515 | SELENOK | GSM4909300 | Human | Breast | IDC | 1.95e-02 | 3.29e-01 | 0.0334 |
58515 | SELENOK | GSM4909301 | Human | Breast | IDC | 5.13e-07 | 4.32e-01 | 0.1577 |
58515 | SELENOK | GSM4909305 | Human | Breast | IDC | 7.03e-07 | 2.18e-01 | 0.0436 |
58515 | SELENOK | GSM4909306 | Human | Breast | IDC | 3.92e-03 | 1.26e-01 | 0.1564 |
58515 | SELENOK | GSM4909308 | Human | Breast | IDC | 5.67e-15 | 2.86e-01 | 0.158 |
58515 | SELENOK | GSM4909311 | Human | Breast | IDC | 3.21e-13 | -1.64e-01 | 0.1534 |
58515 | SELENOK | GSM4909319 | Human | Breast | IDC | 8.35e-20 | -6.02e-02 | 0.1563 |
58515 | SELENOK | ctrl6 | Human | Breast | Precancer | 3.22e-20 | 7.21e-01 | -0.0061 |
58515 | SELENOK | brca1 | Human | Breast | Precancer | 1.06e-23 | -4.89e-01 | -0.0338 |
58515 | SELENOK | brca2 | Human | Breast | Precancer | 2.31e-20 | -4.89e-01 | -0.024 |
58515 | SELENOK | brca3 | Human | Breast | Precancer | 2.31e-20 | -4.89e-01 | -0.0263 |
58515 | SELENOK | brca10 | Human | Breast | Precancer | 2.97e-32 | 8.18e-01 | -0.0029 |
58515 | SELENOK | brca11 | Human | Breast | Precancer | 2.81e-02 | 6.74e-01 | 0.0193 |
58515 | SELENOK | M1 | Human | Breast | IDC | 1.90e-02 | 1.22e-01 | 0.1577 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00026878 | Cervix | CC | positive regulation of leukocyte migration | 35/2311 | 135/18723 | 1.25e-05 | 2.60e-04 | 35 |
GO:00329444 | Cervix | CC | regulation of mononuclear cell proliferation | 51/2311 | 227/18723 | 1.36e-05 | 2.73e-04 | 51 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:00508708 | Cervix | CC | positive regulation of T cell activation | 49/2311 | 216/18723 | 1.51e-05 | 2.97e-04 | 49 |
GO:00716755 | Cervix | CC | regulation of mononuclear cell migration | 31/2311 | 115/18723 | 1.67e-05 | 3.22e-04 | 31 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00706617 | Cervix | CC | leukocyte proliferation | 65/2311 | 318/18723 | 2.56e-05 | 4.32e-04 | 65 |
GO:00466516 | Cervix | CC | lymphocyte proliferation | 59/2311 | 288/18723 | 5.53e-05 | 8.10e-04 | 59 |
GO:00716775 | Cervix | CC | positive regulation of mononuclear cell migration | 20/2311 | 65/18723 | 6.96e-05 | 9.81e-04 | 20 |
GO:00457306 | Cervix | CC | respiratory burst | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:00329435 | Cervix | CC | mononuclear cell proliferation | 59/2311 | 291/18723 | 7.51e-05 | 1.03e-03 | 59 |
GO:00324698 | Cervix | CC | endoplasmic reticulum calcium ion homeostasis | 10/2311 | 25/18723 | 4.52e-04 | 4.49e-03 | 10 |
GO:20004033 | Cervix | CC | positive regulation of lymphocyte migration | 12/2311 | 35/18723 | 6.55e-04 | 6.05e-03 | 12 |
GO:00716745 | Cervix | CC | mononuclear cell migration | 40/2311 | 196/18723 | 8.79e-04 | 7.62e-03 | 40 |
GO:00026967 | Cervix | CC | positive regulation of leukocyte activation | 72/2311 | 409/18723 | 1.13e-03 | 9.31e-03 | 72 |
GO:00512516 | Cervix | CC | positive regulation of lymphocyte activation | 65/2311 | 362/18723 | 1.15e-03 | 9.39e-03 | 65 |
GO:20004043 | Cervix | CC | regulation of T cell migration | 13/2311 | 42/18723 | 1.18e-03 | 9.56e-03 | 13 |
GO:00508676 | Cervix | CC | positive regulation of cell activation | 73/2311 | 420/18723 | 1.50e-03 | 1.16e-02 | 73 |
GO:20004063 | Cervix | CC | positive regulation of T cell migration | 10/2311 | 29/18723 | 1.74e-03 | 1.31e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOK | SNV | Missense_Mutation | c.14N>G | p.Ser5Trp | p.S5W | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SELENOK | SNV | Missense_Mutation | c.149N>A | p.Arg50Lys | p.R50K | protein_coding | tolerated(0.48) | benign(0.026) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SELENOK | SNV | Missense_Mutation | c.245N>A | p.Gly82Asp | p.G82D | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SELENOK | deletion | Frame_Shift_Del | novel | c.145delA | p.Arg49GlufsTer51 | p.R49Efs*51 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
SELENOK | SNV | Missense_Mutation | c.81N>A | p.Phe27Leu | p.F27L | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SELENOK | SNV | Missense_Mutation | rs376660375 | c.241N>T | p.Arg81Cys | p.R81C | protein_coding | deleterious(0.04) | benign(0.192) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SELENOK | deletion | Frame_Shift_Del | novel | c.145delN | p.Arg49GlufsTer51 | p.R49Efs*51 | protein_coding | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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