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Gene: SEC22B |
Gene summary for SEC22B |
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Gene information | Species | Human | Gene symbol | SEC22B | Gene ID | 9554 |
Gene name | SEC22 homolog B, vesicle trafficking protein | |
Gene Alias | ERS-24 | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O75396 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9554 | SEC22B | LZE4T | Human | Esophagus | ESCC | 2.13e-09 | 2.93e-01 | 0.0811 |
9554 | SEC22B | LZE5T | Human | Esophagus | ESCC | 9.17e-06 | 3.63e-01 | 0.0514 |
9554 | SEC22B | LZE7T | Human | Esophagus | ESCC | 9.82e-08 | 4.25e-01 | 0.0667 |
9554 | SEC22B | LZE8T | Human | Esophagus | ESCC | 5.87e-03 | 1.15e-01 | 0.067 |
9554 | SEC22B | LZE20T | Human | Esophagus | ESCC | 2.67e-04 | 2.40e-01 | 0.0662 |
9554 | SEC22B | LZE24T | Human | Esophagus | ESCC | 2.42e-26 | 5.98e-01 | 0.0596 |
9554 | SEC22B | LZE6T | Human | Esophagus | ESCC | 1.03e-08 | 2.30e-01 | 0.0845 |
9554 | SEC22B | P1T-E | Human | Esophagus | ESCC | 7.58e-04 | 2.79e-01 | 0.0875 |
9554 | SEC22B | P2T-E | Human | Esophagus | ESCC | 8.01e-25 | 4.41e-01 | 0.1177 |
9554 | SEC22B | P4T-E | Human | Esophagus | ESCC | 5.08e-23 | 5.18e-01 | 0.1323 |
9554 | SEC22B | P5T-E | Human | Esophagus | ESCC | 1.47e-12 | 3.63e-01 | 0.1327 |
9554 | SEC22B | P8T-E | Human | Esophagus | ESCC | 5.45e-25 | 5.04e-01 | 0.0889 |
9554 | SEC22B | P9T-E | Human | Esophagus | ESCC | 9.08e-16 | 3.22e-01 | 0.1131 |
9554 | SEC22B | P10T-E | Human | Esophagus | ESCC | 1.12e-34 | 7.01e-01 | 0.116 |
9554 | SEC22B | P11T-E | Human | Esophagus | ESCC | 1.29e-09 | 4.63e-01 | 0.1426 |
9554 | SEC22B | P12T-E | Human | Esophagus | ESCC | 1.88e-26 | 5.29e-01 | 0.1122 |
9554 | SEC22B | P15T-E | Human | Esophagus | ESCC | 8.43e-16 | 2.94e-01 | 0.1149 |
9554 | SEC22B | P16T-E | Human | Esophagus | ESCC | 3.40e-18 | 3.82e-01 | 0.1153 |
9554 | SEC22B | P17T-E | Human | Esophagus | ESCC | 4.50e-10 | 5.46e-01 | 0.1278 |
9554 | SEC22B | P19T-E | Human | Esophagus | ESCC | 5.34e-05 | 5.46e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605017 | Thyroid | PTC | vesicle organization | 163/5968 | 300/18723 | 4.74e-16 | 3.69e-14 | 163 |
GO:000688817 | Thyroid | PTC | endoplasmic reticulum to Golgi vesicle-mediated transport | 83/5968 | 130/18723 | 6.19e-14 | 3.52e-12 | 83 |
GO:001624110 | Thyroid | PTC | regulation of macroautophagy | 84/5968 | 141/18723 | 1.04e-11 | 4.27e-10 | 84 |
GO:0031330113 | Thyroid | PTC | negative regulation of cellular catabolic process | 131/5968 | 262/18723 | 6.63e-10 | 2.03e-08 | 131 |
GO:0009895113 | Thyroid | PTC | negative regulation of catabolic process | 154/5968 | 320/18723 | 7.77e-10 | 2.31e-08 | 154 |
GO:000703315 | Thyroid | PTC | vacuole organization | 96/5968 | 180/18723 | 1.80e-09 | 5.13e-08 | 96 |
GO:0010639112 | Thyroid | PTC | negative regulation of organelle organization | 163/5968 | 348/18723 | 3.04e-09 | 8.39e-08 | 163 |
GO:000689019 | Thyroid | PTC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 37/5968 | 52/18723 | 6.98e-09 | 1.75e-07 | 37 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:000004514 | Thyroid | PTC | autophagosome assembly | 54/5968 | 99/18723 | 2.46e-06 | 3.22e-05 | 54 |
GO:00482846 | Thyroid | PTC | organelle fusion | 71/5968 | 141/18723 | 3.68e-06 | 4.70e-05 | 71 |
GO:190503713 | Thyroid | PTC | autophagosome organization | 55/5968 | 103/18723 | 4.75e-06 | 5.79e-05 | 55 |
GO:190211516 | Thyroid | PTC | regulation of organelle assembly | 88/5968 | 186/18723 | 7.41e-06 | 8.65e-05 | 88 |
GO:00610256 | Thyroid | PTC | membrane fusion | 77/5968 | 163/18723 | 2.86e-05 | 2.78e-04 | 77 |
GO:00069065 | Thyroid | PTC | vesicle fusion | 54/5968 | 106/18723 | 3.39e-05 | 3.21e-04 | 54 |
GO:00901745 | Thyroid | PTC | organelle membrane fusion | 55/5968 | 110/18723 | 5.64e-05 | 4.99e-04 | 55 |
GO:00440886 | Thyroid | PTC | regulation of vacuole organization | 25/5968 | 45/18723 | 8.54e-04 | 5.23e-03 | 25 |
GO:00105077 | Thyroid | PTC | negative regulation of autophagy | 41/5968 | 85/18723 | 1.19e-03 | 6.84e-03 | 41 |
GO:00162423 | Thyroid | PTC | negative regulation of macroautophagy | 19/5968 | 34/18723 | 3.21e-03 | 1.57e-02 | 19 |
GO:20007855 | Thyroid | PTC | regulation of autophagosome assembly | 20/5968 | 39/18723 | 9.09e-03 | 3.76e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0513428 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0513436 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0414514 | Liver | Cirrhotic | Phagosome | 73/2530 | 152/8465 | 1.61e-06 | 1.78e-05 | 1.10e-05 | 73 |
hsa0513412 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa04130 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414515 | Liver | Cirrhotic | Phagosome | 73/2530 | 152/8465 | 1.61e-06 | 1.78e-05 | 1.10e-05 | 73 |
hsa0513413 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa041301 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa0414521 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa041302 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa0414531 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa041303 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa041304 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
hsa0513425 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa0414528 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0413011 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC22B | SNV | Missense_Mutation | novel | c.196N>C | p.Glu66Gln | p.E66Q | O75396 | protein_coding | tolerated(0.14) | benign(0.055) | TCGA-AQ-A0Y5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD |
SEC22B | SNV | Missense_Mutation | novel | c.451N>A | p.Ala151Thr | p.A151T | O75396 | protein_coding | tolerated(0.24) | benign(0.039) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
SEC22B | SNV | Missense_Mutation | novel | c.4G>C | p.Val2Leu | p.V2L | O75396 | protein_coding | tolerated(0.1) | benign(0) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SEC22B | SNV | Missense_Mutation | novel | c.599C>A | p.Ala200Asp | p.A200D | O75396 | protein_coding | deleterious(0.03) | benign(0.436) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEC22B | SNV | Missense_Mutation | novel | c.568C>T | p.Arg190Cys | p.R190C | O75396 | protein_coding | deleterious(0.04) | probably_damaging(0.946) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEC22B | SNV | Missense_Mutation | novel | c.326C>T | p.Pro109Leu | p.P109L | O75396 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SEC22B | SNV | Missense_Mutation | novel | c.224G>A | p.Cys75Tyr | p.C75Y | O75396 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEC22B | SNV | Missense_Mutation | novel | c.178N>C | p.Thr60Pro | p.T60P | O75396 | protein_coding | tolerated(0.2) | benign(0.085) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SEC22B | SNV | Missense_Mutation | novel | c.130N>G | p.Leu44Val | p.L44V | O75396 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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