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Gene: RNF180 |
Gene summary for RNF180 |
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Gene information | Species | Human | Gene symbol | RNF180 | Gene ID | 285671 |
Gene name | ring finger protein 180 | |
Gene Alias | RINES | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q86T96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285671 | RNF180 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.32e-22 | 5.64e-01 | 0.0155 |
285671 | RNF180 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.12e-23 | 8.14e-01 | -0.1808 |
285671 | RNF180 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.22e-10 | 6.19e-01 | 0.0216 |
285671 | RNF180 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.35e-40 | 1.77e+00 | -0.0811 |
285671 | RNF180 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.12e-28 | 8.76e-01 | -0.1088 |
285671 | RNF180 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.63e-29 | 7.25e-01 | -0.1954 |
285671 | RNF180 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.64e-05 | 7.46e-01 | -0.2602 |
285671 | RNF180 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.97e-09 | 8.06e-01 | -0.2196 |
285671 | RNF180 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.64e-14 | 5.35e-01 | -0.1207 |
285671 | RNF180 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.06e-12 | 6.89e-01 | -0.1526 |
285671 | RNF180 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.73e-38 | 8.26e-01 | -0.1464 |
285671 | RNF180 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.83e-21 | 5.62e-01 | -0.1001 |
285671 | RNF180 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.89e-21 | 6.65e-01 | -0.059 |
285671 | RNF180 | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.71e-09 | 4.51e-01 | -0.1706 |
285671 | RNF180 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.29e-04 | 3.34e-01 | -0.0842 |
285671 | RNF180 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.66e-04 | 8.24e-01 | -0.00410000000000005 |
285671 | RNF180 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.06e-21 | 8.58e-01 | -0.0179 |
285671 | RNF180 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.43e-15 | 5.98e-01 | 0.096 |
285671 | RNF180 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.60e-105 | 2.06e+00 | 0.294 |
285671 | RNF180 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.19e-19 | 1.62e+00 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003243613 | Lung | AIS | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 25/1849 | 90/18723 | 1.25e-06 | 8.19e-05 | 25 |
GO:003243413 | Lung | AIS | regulation of proteasomal ubiquitin-dependent protein catabolic process | 32/1849 | 134/18723 | 1.76e-06 | 1.05e-04 | 32 |
GO:006113613 | Lung | AIS | regulation of proteasomal protein catabolic process | 39/1849 | 187/18723 | 5.12e-06 | 2.47e-04 | 39 |
GO:190180013 | Lung | AIS | positive regulation of proteasomal protein catabolic process | 27/1849 | 114/18723 | 1.30e-05 | 4.85e-04 | 27 |
GO:190332211 | Lung | AIS | positive regulation of protein modification by small protein conjugation or removal | 25/1849 | 138/18723 | 2.05e-03 | 2.26e-02 | 25 |
GO:003139811 | Lung | AIS | positive regulation of protein ubiquitination | 22/1849 | 119/18723 | 2.85e-03 | 2.84e-02 | 22 |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
GO:1903362113 | Thyroid | PTC | regulation of cellular protein catabolic process | 162/5968 | 255/18723 | 1.62e-25 | 5.12e-23 | 162 |
GO:1903050113 | Thyroid | PTC | regulation of proteolysis involved in cellular protein catabolic process | 140/5968 | 221/18723 | 4.63e-22 | 1.01e-19 | 140 |
GO:1903320113 | Thyroid | PTC | regulation of protein modification by small protein conjugation or removal | 148/5968 | 242/18723 | 4.49e-21 | 8.10e-19 | 148 |
GO:0045732113 | Thyroid | PTC | positive regulation of protein catabolic process | 142/5968 | 231/18723 | 1.43e-20 | 2.38e-18 | 142 |
GO:2000058113 | Thyroid | PTC | regulation of ubiquitin-dependent protein catabolic process | 110/5968 | 164/18723 | 1.83e-20 | 2.97e-18 | 110 |
GO:0061136113 | Thyroid | PTC | regulation of proteasomal protein catabolic process | 121/5968 | 187/18723 | 2.25e-20 | 3.37e-18 | 121 |
GO:0032434113 | Thyroid | PTC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 94/5968 | 134/18723 | 9.17e-20 | 1.23e-17 | 94 |
GO:1903364113 | Thyroid | PTC | positive regulation of cellular protein catabolic process | 104/5968 | 155/18723 | 1.93e-19 | 2.39e-17 | 104 |
GO:0031396113 | Thyroid | PTC | regulation of protein ubiquitination | 128/5968 | 210/18723 | 3.06e-18 | 3.27e-16 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF180 | SNV | Missense_Mutation | novel | c.1502N>C | p.Ile501Thr | p.I501T | Q86T96 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF180 | SNV | Missense_Mutation | c.1037C>T | p.Ser346Leu | p.S346L | Q86T96 | protein_coding | tolerated(0.27) | benign(0.203) | TCGA-BH-A0DT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
RNF180 | SNV | Missense_Mutation | c.1378N>A | p.Leu460Met | p.L460M | Q86T96 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
RNF180 | SNV | Missense_Mutation | novel | c.1497N>C | p.Leu499Phe | p.L499F | Q86T96 | protein_coding | tolerated(0.05) | benign(0.246) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RNF180 | insertion | Frame_Shift_Ins | novel | c.710_711insTTGCTATTACTTTCTCCTCCTTTTCCTTCCTCCTTCCTCCGTGTGG | p.Glu237AspfsTer26 | p.E237Dfs*26 | Q86T96 | protein_coding | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
RNF180 | SNV | Missense_Mutation | novel | c.1223N>T | p.His408Leu | p.H408L | Q86T96 | protein_coding | tolerated(0.33) | benign(0.039) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RNF180 | SNV | Missense_Mutation | rs373363351 | c.186G>C | p.Met62Ile | p.M62I | Q86T96 | protein_coding | tolerated(0.06) | benign(0.292) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RNF180 | SNV | Missense_Mutation | c.832N>A | p.Tyr278Asn | p.Y278N | Q86T96 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RNF180 | SNV | Missense_Mutation | novel | c.1592A>G | p.His531Arg | p.H531R | Q86T96 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF180 | SNV | Missense_Mutation | novel | c.443N>G | p.Asp148Gly | p.D148G | Q86T96 | protein_coding | tolerated(0.09) | benign(0.057) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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