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Gene: RIOK2 |
Gene summary for RIOK2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RIOK2 | Gene ID | 55781 |
| Gene name | RIO kinase 2 | |
| Gene Alias | RIO2 | |
| Cytomap | 5q15 | |
| Gene Type | protein-coding | GO ID | GO:0000054 | UniProtAcc | Q9BVS4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55781 | RIOK2 | LZE4T | Human | Esophagus | ESCC | 3.71e-06 | 1.76e-01 | 0.0811 |
| 55781 | RIOK2 | LZE24T | Human | Esophagus | ESCC | 1.20e-07 | 1.90e-01 | 0.0596 |
| 55781 | RIOK2 | P2T-E | Human | Esophagus | ESCC | 1.89e-11 | 2.28e-01 | 0.1177 |
| 55781 | RIOK2 | P4T-E | Human | Esophagus | ESCC | 2.86e-09 | 2.48e-01 | 0.1323 |
| 55781 | RIOK2 | P5T-E | Human | Esophagus | ESCC | 3.03e-10 | 2.26e-01 | 0.1327 |
| 55781 | RIOK2 | P8T-E | Human | Esophagus | ESCC | 8.57e-03 | 6.39e-02 | 0.0889 |
| 55781 | RIOK2 | P9T-E | Human | Esophagus | ESCC | 1.45e-02 | 5.92e-02 | 0.1131 |
| 55781 | RIOK2 | P10T-E | Human | Esophagus | ESCC | 1.10e-03 | 1.05e-01 | 0.116 |
| 55781 | RIOK2 | P12T-E | Human | Esophagus | ESCC | 5.70e-15 | 3.59e-01 | 0.1122 |
| 55781 | RIOK2 | P15T-E | Human | Esophagus | ESCC | 2.28e-13 | 2.65e-01 | 0.1149 |
| 55781 | RIOK2 | P16T-E | Human | Esophagus | ESCC | 2.55e-10 | 7.55e-02 | 0.1153 |
| 55781 | RIOK2 | P20T-E | Human | Esophagus | ESCC | 4.41e-14 | 2.91e-01 | 0.1124 |
| 55781 | RIOK2 | P21T-E | Human | Esophagus | ESCC | 1.73e-06 | 1.96e-01 | 0.1617 |
| 55781 | RIOK2 | P22T-E | Human | Esophagus | ESCC | 5.07e-17 | 2.95e-01 | 0.1236 |
| 55781 | RIOK2 | P23T-E | Human | Esophagus | ESCC | 1.39e-14 | 3.00e-01 | 0.108 |
| 55781 | RIOK2 | P24T-E | Human | Esophagus | ESCC | 4.08e-12 | 2.38e-01 | 0.1287 |
| 55781 | RIOK2 | P26T-E | Human | Esophagus | ESCC | 1.13e-19 | 3.33e-01 | 0.1276 |
| 55781 | RIOK2 | P27T-E | Human | Esophagus | ESCC | 9.08e-09 | 1.53e-01 | 0.1055 |
| 55781 | RIOK2 | P30T-E | Human | Esophagus | ESCC | 3.43e-05 | 2.00e-01 | 0.137 |
| 55781 | RIOK2 | P31T-E | Human | Esophagus | ESCC | 3.39e-08 | 1.13e-01 | 0.1251 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00002803 | Skin | cSCC | nuclear division | 178/4864 | 439/18723 | 1.17e-11 | 5.93e-10 | 178 |
| GO:0032388111 | Skin | cSCC | positive regulation of intracellular transport | 96/4864 | 202/18723 | 3.14e-11 | 1.52e-09 | 96 |
| GO:0046822111 | Skin | cSCC | regulation of nucleocytoplasmic transport | 59/4864 | 106/18723 | 8.03e-11 | 3.68e-09 | 59 |
| GO:190199014 | Skin | cSCC | regulation of mitotic cell cycle phase transition | 128/4864 | 299/18723 | 1.48e-10 | 6.56e-09 | 128 |
| GO:00519834 | Skin | cSCC | regulation of chromosome segregation | 52/4864 | 91/18723 | 2.88e-10 | 1.20e-08 | 52 |
| GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
| GO:00070913 | Skin | cSCC | metaphase/anaphase transition of mitotic cell cycle | 37/4864 | 62/18723 | 2.13e-08 | 6.11e-07 | 37 |
| GO:00330453 | Skin | cSCC | regulation of sister chromatid segregation | 41/4864 | 72/18723 | 2.48e-08 | 6.89e-07 | 41 |
| GO:19058183 | Skin | cSCC | regulation of chromosome separation | 41/4864 | 72/18723 | 2.48e-08 | 6.89e-07 | 41 |
| GO:00300713 | Skin | cSCC | regulation of mitotic metaphase/anaphase transition | 36/4864 | 60/18723 | 2.71e-08 | 7.41e-07 | 36 |
| GO:00109653 | Skin | cSCC | regulation of mitotic sister chromatid separation | 38/4864 | 65/18723 | 3.03e-08 | 8.18e-07 | 38 |
| GO:190198714 | Skin | cSCC | regulation of cell cycle phase transition | 150/4864 | 390/18723 | 3.21e-08 | 8.61e-07 | 150 |
| GO:00513063 | Skin | cSCC | mitotic sister chromatid separation | 38/4864 | 67/18723 | 9.27e-08 | 2.22e-06 | 38 |
| GO:00447843 | Skin | cSCC | metaphase/anaphase transition of cell cycle | 37/4864 | 65/18723 | 1.20e-07 | 2.79e-06 | 37 |
| GO:19020993 | Skin | cSCC | regulation of metaphase/anaphase transition of cell cycle | 36/4864 | 63/18723 | 1.55e-07 | 3.51e-06 | 36 |
| GO:000005412 | Skin | cSCC | ribosomal subunit export from nucleus | 13/4864 | 14/18723 | 2.58e-07 | 5.33e-06 | 13 |
| GO:003375012 | Skin | cSCC | ribosome localization | 13/4864 | 14/18723 | 2.58e-07 | 5.33e-06 | 13 |
| GO:004682419 | Skin | cSCC | positive regulation of nucleocytoplasmic transport | 34/4864 | 62/18723 | 1.27e-06 | 2.20e-05 | 34 |
| GO:00714285 | Skin | cSCC | rRNA-containing ribonucleoprotein complex export from nucleus | 13/4864 | 15/18723 | 1.47e-06 | 2.52e-05 | 13 |
| GO:00513043 | Skin | cSCC | chromosome separation | 44/4864 | 96/18723 | 2.05e-05 | 2.40e-04 | 44 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RIOK2 | SNV | Missense_Mutation | c.703N>G | p.Ile235Val | p.I235V | Q9BVS4 | protein_coding | deleterious(0) | benign(0.314) | TCGA-A2-A0YF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Arimidex | SD | |
| RIOK2 | SNV | Missense_Mutation | c.377G>A | p.Arg126Lys | p.R126K | Q9BVS4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
| RIOK2 | SNV | Missense_Mutation | c.1556N>A | p.Arg519His | p.R519H | Q9BVS4 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| RIOK2 | SNV | Missense_Mutation | novel | c.682G>T | p.Asp228Tyr | p.D228Y | Q9BVS4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RIOK2 | SNV | Missense_Mutation | c.775N>C | p.Glu259Gln | p.E259Q | Q9BVS4 | protein_coding | tolerated(0.15) | possibly_damaging(0.74) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
| RIOK2 | SNV | Missense_Mutation | novel | c.46N>A | p.Asp16Asn | p.D16N | Q9BVS4 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RIOK2 | SNV | Missense_Mutation | rs373094809 | c.1352N>G | p.His451Arg | p.H451R | Q9BVS4 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RIOK2 | SNV | Missense_Mutation | c.742C>T | p.Pro248Ser | p.P248S | Q9BVS4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RIOK2 | SNV | Missense_Mutation | c.1066C>T | p.Arg356Trp | p.R356W | Q9BVS4 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| RIOK2 | SNV | Missense_Mutation | novel | c.1064N>G | p.Glu355Gly | p.E355G | Q9BVS4 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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