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Gene: RHEB |
Gene summary for RHEB |
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Gene information | Species | Human | Gene symbol | RHEB | Gene ID | 6009 |
Gene name | Ras homolog, mTORC1 binding | |
Gene Alias | RHEB2 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | A0A090N900 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6009 | RHEB | GSM4909282 | Human | Breast | IDC | 1.38e-74 | 8.26e-01 | -0.0288 |
6009 | RHEB | GSM4909285 | Human | Breast | IDC | 6.21e-03 | 2.52e-01 | 0.21 |
6009 | RHEB | GSM4909288 | Human | Breast | IDC | 2.41e-04 | -3.13e-01 | 0.0988 |
6009 | RHEB | GSM4909293 | Human | Breast | IDC | 2.31e-02 | -2.68e-01 | 0.1581 |
6009 | RHEB | GSM4909294 | Human | Breast | IDC | 2.20e-05 | -2.67e-01 | 0.2022 |
6009 | RHEB | GSM4909296 | Human | Breast | IDC | 1.34e-18 | -4.14e-01 | 0.1524 |
6009 | RHEB | GSM4909297 | Human | Breast | IDC | 1.47e-25 | -5.06e-01 | 0.1517 |
6009 | RHEB | GSM4909301 | Human | Breast | IDC | 1.53e-18 | -5.84e-01 | 0.1577 |
6009 | RHEB | GSM4909304 | Human | Breast | IDC | 7.42e-04 | -3.31e-01 | 0.1636 |
6009 | RHEB | GSM4909309 | Human | Breast | IDC | 1.47e-05 | -2.16e-01 | 0.0483 |
6009 | RHEB | GSM4909311 | Human | Breast | IDC | 6.42e-48 | -6.81e-01 | 0.1534 |
6009 | RHEB | GSM4909312 | Human | Breast | IDC | 3.49e-17 | -3.44e-01 | 0.1552 |
6009 | RHEB | GSM4909313 | Human | Breast | IDC | 3.12e-09 | -3.07e-01 | 0.0391 |
6009 | RHEB | GSM4909317 | Human | Breast | IDC | 4.01e-03 | -2.82e-01 | 0.1355 |
6009 | RHEB | GSM4909319 | Human | Breast | IDC | 8.28e-50 | -4.67e-01 | 0.1563 |
6009 | RHEB | GSM4909320 | Human | Breast | IDC | 1.37e-09 | -5.39e-01 | 0.1575 |
6009 | RHEB | GSM4909321 | Human | Breast | IDC | 7.64e-28 | -5.19e-01 | 0.1559 |
6009 | RHEB | brca1 | Human | Breast | Precancer | 4.60e-12 | 4.07e-01 | -0.0338 |
6009 | RHEB | brca2 | Human | Breast | Precancer | 4.42e-03 | 1.88e-01 | -0.024 |
6009 | RHEB | brca3 | Human | Breast | Precancer | 1.63e-07 | 3.05e-01 | -0.0263 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000206424 | Oral cavity | NEOLP | epithelial cell development | 45/2005 | 220/18723 | 1.45e-05 | 2.54e-04 | 45 |
GO:001623631 | Oral cavity | NEOLP | macroautophagy | 54/2005 | 291/18723 | 3.95e-05 | 5.62e-04 | 54 |
GO:005076921 | Oral cavity | NEOLP | positive regulation of neurogenesis | 44/2005 | 225/18723 | 5.60e-05 | 7.58e-04 | 44 |
GO:005076721 | Oral cavity | NEOLP | regulation of neurogenesis | 62/2005 | 364/18723 | 1.50e-04 | 1.71e-03 | 62 |
GO:005196212 | Oral cavity | NEOLP | positive regulation of nervous system development | 47/2005 | 272/18723 | 6.49e-04 | 5.47e-03 | 47 |
GO:001624131 | Oral cavity | NEOLP | regulation of macroautophagy | 28/2005 | 141/18723 | 9.15e-04 | 7.13e-03 | 28 |
GO:005196012 | Oral cavity | NEOLP | regulation of nervous system development | 68/2005 | 443/18723 | 1.46e-03 | 1.03e-02 | 68 |
GO:004206321 | Oral cavity | NEOLP | gliogenesis | 47/2005 | 301/18723 | 5.26e-03 | 2.82e-02 | 47 |
GO:001000121 | Oral cavity | NEOLP | glial cell differentiation | 37/2005 | 225/18723 | 5.38e-03 | 2.88e-02 | 37 |
GO:000165911 | Oral cavity | NEOLP | temperature homeostasis | 30/2005 | 174/18723 | 5.83e-03 | 3.04e-02 | 30 |
GO:199084512 | Oral cavity | NEOLP | adaptive thermogenesis | 27/2005 | 157/18723 | 8.87e-03 | 4.25e-02 | 27 |
GO:0120163 | Oral cavity | NEOLP | negative regulation of cold-induced thermogenesis | 11/2005 | 47/18723 | 9.45e-03 | 4.47e-02 | 11 |
GO:010610612 | Oral cavity | NEOLP | cold-induced thermogenesis | 25/2005 | 144/18723 | 1.02e-02 | 4.77e-02 | 25 |
GO:012016112 | Oral cavity | NEOLP | regulation of cold-induced thermogenesis | 25/2005 | 144/18723 | 1.02e-02 | 4.77e-02 | 25 |
GO:000206417 | Prostate | BPH | epithelial cell development | 85/3107 | 220/18723 | 3.16e-15 | 4.55e-13 | 85 |
GO:00162369 | Prostate | BPH | macroautophagy | 85/3107 | 291/18723 | 4.68e-08 | 1.29e-06 | 85 |
GO:00107208 | Prostate | BPH | positive regulation of cell development | 86/3107 | 298/18723 | 7.11e-08 | 1.85e-06 | 86 |
GO:00105069 | Prostate | BPH | regulation of autophagy | 86/3107 | 317/18723 | 1.29e-06 | 2.24e-05 | 86 |
GO:00507695 | Prostate | BPH | positive regulation of neurogenesis | 63/3107 | 225/18723 | 1.11e-05 | 1.51e-04 | 63 |
GO:00507678 | Prostate | BPH | regulation of neurogenesis | 92/3107 | 364/18723 | 1.36e-05 | 1.78e-04 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516316 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516317 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0421824 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0516324 | Breast | IDC | Human cytomegalovirus infection | 39/867 | 225/8465 | 6.66e-04 | 5.41e-03 | 4.05e-03 | 39 |
hsa0491916 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0421834 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0516334 | Breast | IDC | Human cytomegalovirus infection | 39/867 | 225/8465 | 6.66e-04 | 5.41e-03 | 4.05e-03 | 39 |
hsa0491917 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0421844 | Breast | DCIS | Cellular senescence | 34/846 | 156/8465 | 8.53e-06 | 1.06e-04 | 7.80e-05 | 34 |
hsa0516344 | Breast | DCIS | Human cytomegalovirus infection | 38/846 | 225/8465 | 8.11e-04 | 5.95e-03 | 4.38e-03 | 38 |
hsa0491922 | Breast | DCIS | Thyroid hormone signaling pathway | 23/846 | 121/8465 | 1.78e-03 | 1.22e-02 | 9.00e-03 | 23 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0421854 | Breast | DCIS | Cellular senescence | 34/846 | 156/8465 | 8.53e-06 | 1.06e-04 | 7.80e-05 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHEB | SNV | Missense_Mutation | c.85N>A | p.Gly29Ser | p.G29S | Q15382 | protein_coding | tolerated(0.07) | probably_damaging(0.967) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHEB | insertion | Nonsense_Mutation | novel | c.100_101insACAAAGCCTAAAATATTTACTGGTACTGTCTGGC | p.Ser34TyrfsTer4 | p.S34Yfs*4 | Q15382 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
RHEB | SNV | Missense_Mutation | c.125N>T | p.Thr42Ile | p.T42I | Q15382 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | rs867628277 | c.68N>T | p.Thr23Met | p.T23M | Q15382 | protein_coding | deleterious(0) | benign(0.288) | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RHEB | SNV | Missense_Mutation | c.383T>A | p.Val128Glu | p.V128E | Q15382 | protein_coding | tolerated(0.58) | benign(0.026) | TCGA-G5-6641-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RHEB | SNV | Missense_Mutation | c.125C>A | p.Thr42Asn | p.T42N | Q15382 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | c.103N>A | p.Tyr35Asn | p.Y35N | Q15382 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | novel | c.449C>T | p.Ala150Val | p.A150V | Q15382 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHEB | SNV | Missense_Mutation | c.70N>G | p.Ile24Val | p.I24V | Q15382 | protein_coding | tolerated(0.99) | possibly_damaging(0.65) | TCGA-BS-A0V6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | novel | c.78N>G | p.Phe26Leu | p.F26L | Q15382 | protein_coding | deleterious(0.02) | possibly_damaging(0.693) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6009 | RHEB | TUMOR SUPPRESSOR, DRUG RESISTANCE, KINASE, CLINICALLY ACTIONABLE | 4,4'-HYDROXYBIPHENYL | CHEMBL76398 | 24266771 | |
6009 | RHEB | TUMOR SUPPRESSOR, DRUG RESISTANCE, KINASE, CLINICALLY ACTIONABLE | SIROLIMUS | SIROLIMUS | 26255626 |
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