Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PPARD_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PPARD_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PPARD_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPARD_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PPARD_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPARD_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00320246 | Endometrium | AEH | positive regulation of insulin secretion | 19/2100 | 78/18723 | 8.09e-04 | 7.62e-03 | 19 |
GO:00303082 | Endometrium | AEH | negative regulation of cell growth | 36/2100 | 188/18723 | 9.15e-04 | 8.37e-03 | 36 |
GO:00507149 | Endometrium | AEH | positive regulation of protein secretion | 28/2100 | 137/18723 | 1.17e-03 | 1.01e-02 | 28 |
GO:00357743 | Endometrium | AEH | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 11/2100 | 36/18723 | 1.44e-03 | 1.20e-02 | 11 |
GO:00075665 | Endometrium | AEH | embryo implantation | 14/2100 | 53/18723 | 1.67e-03 | 1.36e-02 | 14 |
GO:00486396 | Endometrium | AEH | positive regulation of developmental growth | 33/2100 | 174/18723 | 1.72e-03 | 1.38e-02 | 33 |
GO:00456823 | Endometrium | AEH | regulation of epidermis development | 16/2100 | 65/18723 | 1.81e-03 | 1.44e-02 | 16 |
GO:0061448 | Endometrium | AEH | connective tissue development | 44/2100 | 252/18723 | 1.92e-03 | 1.51e-02 | 44 |
GO:007145310 | Endometrium | AEH | cellular response to oxygen levels | 33/2100 | 177/18723 | 2.30e-03 | 1.74e-02 | 33 |
GO:00507967 | Endometrium | AEH | regulation of insulin secretion | 31/2100 | 165/18723 | 2.71e-03 | 1.96e-02 | 31 |
GO:00459278 | Endometrium | AEH | positive regulation of growth | 44/2100 | 259/18723 | 3.28e-03 | 2.30e-02 | 44 |
GO:00712229 | Endometrium | AEH | cellular response to lipopolysaccharide | 37/2100 | 209/18723 | 3.30e-03 | 2.31e-02 | 37 |
GO:0048662 | Endometrium | AEH | negative regulation of smooth muscle cell proliferation | 17/2100 | 75/18723 | 3.39e-03 | 2.36e-02 | 17 |
GO:00712169 | Endometrium | AEH | cellular response to biotic stimulus | 42/2100 | 246/18723 | 3.65e-03 | 2.50e-02 | 42 |
GO:00149103 | Endometrium | AEH | regulation of smooth muscle cell migration | 19/2100 | 89/18723 | 4.12e-03 | 2.73e-02 | 19 |
GO:00716927 | Endometrium | AEH | protein localization to extracellular region | 58/2100 | 368/18723 | 4.72e-03 | 3.00e-02 | 58 |
GO:00192165 | Endometrium | AEH | regulation of lipid metabolic process | 53/2100 | 331/18723 | 4.86e-03 | 3.07e-02 | 53 |
GO:00085447 | Endometrium | AEH | epidermis development | 52/2100 | 324/18723 | 5.00e-03 | 3.14e-02 | 52 |
GO:00149092 | Endometrium | AEH | smooth muscle cell migration | 20/2100 | 97/18723 | 5.00e-03 | 3.14e-02 | 20 |
GO:0014912 | Endometrium | AEH | negative regulation of smooth muscle cell migration | 11/2100 | 42/18723 | 5.45e-03 | 3.37e-02 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPARD | SNV | Missense_Mutation | rs767428713 | c.941N>A | p.Arg314His | p.R314H | Q03181 | protein_coding | tolerated(0.06) | benign(0.082) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
PPARD | SNV | Missense_Mutation | | c.448G>C | p.Glu150Gln | p.E150Q | Q03181 | protein_coding | tolerated(1) | possibly_damaging(0.826) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
PPARD | insertion | In_Frame_Ins | novel | c.666_667insAAAGCCAGCCACACGGCGGTGAGT | p.Ala222_Glu223insLysAlaSerHisThrAlaValSer | p.A222_E223insKASHTAVS | Q03181 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
PPARD | insertion | In_Frame_Ins | novel | c.1108_1109insCTTGGTCTGTCACGGCCAAGGAGGCCTGCCGTCCCC | p.Val370delinsAlaTrpSerValThrAlaLysGluAlaCysArgProLeu | p.V370delinsAWSVTAKEACRPL | Q03181 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
PPARD | insertion | Frame_Shift_Ins | novel | c.1139_1140insATCATTCTGTGTGGAGGTGAGTGAGAGTGGGGCAGGTGGGCTGG | p.Leu381SerfsTer51 | p.L381Sfs*51 | Q03181 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPARD | SNV | Missense_Mutation | novel | c.136T>C | p.Ser46Pro | p.S46P | Q03181 | protein_coding | tolerated(0.11) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PPARD | SNV | Missense_Mutation | rs765360583 | c.308G>A | p.Arg103His | p.R103H | Q03181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PPARD | SNV | Missense_Mutation | | c.431N>A | p.Arg144His | p.R144H | Q03181 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PPARD | SNV | Missense_Mutation | novel | c.684N>C | p.Trp228Cys | p.W228C | Q03181 | protein_coding | tolerated(0.31) | probably_damaging(0.98) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPARD | SNV | Missense_Mutation | | c.592N>T | p.Arg198Cys | p.R198C | Q03181 | protein_coding | deleterious(0.02) | benign(0.409) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | PROPACHLOR | PROPACHLOR | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | DICHLOROPHEN | DICHLOROPHEN | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | BISPHENOL A | BISPHENOL A | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | TCMDC-123920 | CHEMBL1606 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | GW7647 | GW7647 | 18162399 |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | HYDRAMETHYLNON | HYDRAMETHYLNON | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | agonist | CHEMBL3544958 | CER-002 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | 12-HYDROXY-OCTADECANOIC ACID | CHEMBL292352 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | L-165041 | CHEMBL153057 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | | CLOTRIMAZOLE | CLOTRIMAZOLE | |