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Gene: PKDCC |
Gene summary for PKDCC |
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Gene information | Species | Human | Gene symbol | PKDCC | Gene ID | 91461 |
Gene name | protein kinase domain containing, cytoplasmic | |
Gene Alias | RLSDF | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q504Y2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91461 | PKDCC | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.61e-02 | 4.55e-01 | -0.0811 |
91461 | PKDCC | HTA11_347_2000001011 | Human | Colorectum | AD | 2.45e-05 | 3.96e-01 | -0.1954 |
91461 | PKDCC | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.17e-07 | 6.31e-01 | -0.059 |
91461 | PKDCC | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.06e-03 | 5.62e-01 | 0.0528 |
91461 | PKDCC | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.47e-08 | 8.69e-01 | 0.0131 |
91461 | PKDCC | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.11e-08 | -2.92e-01 | 0.294 |
91461 | PKDCC | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.65e-07 | 6.38e-01 | 0.3859 |
91461 | PKDCC | F007 | Human | Colorectum | FAP | 1.08e-03 | -3.12e-01 | 0.1176 |
91461 | PKDCC | A002-C-010 | Human | Colorectum | FAP | 4.36e-08 | -3.07e-01 | 0.242 |
91461 | PKDCC | A001-C-207 | Human | Colorectum | FAP | 1.76e-07 | -3.50e-01 | 0.1278 |
91461 | PKDCC | A015-C-203 | Human | Colorectum | FAP | 6.02e-11 | -2.71e-01 | -0.1294 |
91461 | PKDCC | A014-C-040 | Human | Colorectum | FAP | 1.51e-02 | -3.62e-01 | -0.1184 |
91461 | PKDCC | A002-C-201 | Human | Colorectum | FAP | 1.61e-09 | -3.12e-01 | 0.0324 |
91461 | PKDCC | A002-C-203 | Human | Colorectum | FAP | 2.83e-05 | -1.86e-01 | 0.2786 |
91461 | PKDCC | A001-C-119 | Human | Colorectum | FAP | 9.63e-06 | -3.44e-01 | -0.1557 |
91461 | PKDCC | A001-C-108 | Human | Colorectum | FAP | 8.47e-13 | -3.27e-01 | -0.0272 |
91461 | PKDCC | A002-C-021 | Human | Colorectum | FAP | 5.08e-04 | -2.51e-01 | 0.1171 |
91461 | PKDCC | A002-C-205 | Human | Colorectum | FAP | 3.78e-14 | -3.62e-01 | -0.1236 |
91461 | PKDCC | A001-C-104 | Human | Colorectum | FAP | 3.68e-07 | -2.85e-01 | 0.0184 |
91461 | PKDCC | A015-C-005 | Human | Colorectum | FAP | 3.72e-05 | -2.96e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:000689219 | Thyroid | ATC | post-Golgi vesicle-mediated transport | 68/6293 | 104/18723 | 3.30e-11 | 1.10e-09 | 68 |
GO:000689318 | Thyroid | ATC | Golgi to plasma membrane transport | 43/6293 | 60/18723 | 1.85e-09 | 4.53e-08 | 43 |
GO:190437526 | Thyroid | ATC | regulation of protein localization to cell periphery | 74/6293 | 125/18723 | 3.78e-09 | 8.66e-08 | 74 |
GO:1905475111 | Thyroid | ATC | regulation of protein localization to membrane | 96/6293 | 175/18723 | 5.55e-09 | 1.22e-07 | 96 |
GO:009887619 | Thyroid | ATC | vesicle-mediated transport to the plasma membrane | 77/6293 | 136/18723 | 2.86e-08 | 5.43e-07 | 77 |
GO:006195123 | Thyroid | ATC | establishment of protein localization to plasma membrane | 41/6293 | 60/18723 | 4.02e-08 | 7.37e-07 | 41 |
GO:004300117 | Thyroid | ATC | Golgi to plasma membrane protein transport | 30/6293 | 40/18723 | 1.01e-07 | 1.71e-06 | 30 |
GO:190382816 | Thyroid | ATC | negative regulation of cellular protein localization | 67/6293 | 117/18723 | 1.23e-07 | 2.06e-06 | 67 |
GO:190307627 | Thyroid | ATC | regulation of protein localization to plasma membrane | 61/6293 | 104/18723 | 1.38e-07 | 2.26e-06 | 61 |
GO:003032321 | Thyroid | ATC | respiratory tube development | 93/6293 | 181/18723 | 5.67e-07 | 8.02e-06 | 93 |
GO:003032421 | Thyroid | ATC | lung development | 90/6293 | 177/18723 | 1.53e-06 | 1.88e-05 | 90 |
GO:006054121 | Thyroid | ATC | respiratory system development | 100/6293 | 203/18723 | 2.66e-06 | 3.08e-05 | 100 |
GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
GO:00020624 | Thyroid | ATC | chondrocyte differentiation | 54/6293 | 106/18723 | 1.67e-04 | 1.14e-03 | 54 |
GO:00614484 | Thyroid | ATC | connective tissue development | 112/6293 | 252/18723 | 2.08e-04 | 1.38e-03 | 112 |
GO:190307713 | Thyroid | ATC | negative regulation of protein localization to plasma membrane | 17/6293 | 24/18723 | 2.14e-04 | 1.41e-03 | 17 |
GO:190437612 | Thyroid | ATC | negative regulation of protein localization to cell periphery | 17/6293 | 26/18723 | 9.13e-04 | 4.92e-03 | 17 |
GO:001821211 | Thyroid | ATC | peptidyl-tyrosine modification | 156/6293 | 378/18723 | 1.01e-03 | 5.36e-03 | 156 |
GO:190495013 | Thyroid | ATC | negative regulation of establishment of protein localization | 61/6293 | 131/18723 | 1.38e-03 | 7.16e-03 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PKDCC | SNV | Missense_Mutation | novel | c.712C>A | p.Pro238Thr | p.P238T | Q504Y2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
PKDCC | SNV | Missense_Mutation | c.787N>G | p.Leu263Val | p.L263V | Q504Y2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
PKDCC | insertion | Nonsense_Mutation | novel | c.713_714insAAAAATTAGCTGGGCATAG | p.Val239LysfsTer6 | p.V239Kfs*6 | Q504Y2 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
PKDCC | deletion | Frame_Shift_Del | novel | c.1097delG | p.Ser366ThrfsTer124 | p.S366Tfs*124 | Q504Y2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PKDCC | SNV | Missense_Mutation | rs749783255 | c.1012C>T | p.Arg338Trp | p.R338W | Q504Y2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PKDCC | SNV | Missense_Mutation | c.478G>A | p.Gly160Ser | p.G160S | Q504Y2 | protein_coding | tolerated(0.47) | benign(0.154) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PKDCC | SNV | Missense_Mutation | c.1270N>A | p.Cys424Ser | p.C424S | Q504Y2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PKDCC | SNV | Missense_Mutation | rs144832959 | c.782G>A | p.Arg261His | p.R261H | Q504Y2 | protein_coding | deleterious(0.03) | probably_damaging(0.921) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PKDCC | SNV | Missense_Mutation | c.569G>T | p.Arg190Leu | p.R190L | Q504Y2 | protein_coding | deleterious(0.02) | possibly_damaging(0.478) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PKDCC | SNV | Missense_Mutation | rs374316779 | c.820N>A | p.Val274Ile | p.V274I | Q504Y2 | protein_coding | tolerated(0.27) | benign(0.12) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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