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Gene: PDCD5 |
Gene summary for PDCD5 |
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Gene information | Species | Human | Gene symbol | PDCD5 | Gene ID | 9141 |
Gene name | programmed cell death 5 | |
Gene Alias | TFAR19 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0001836 | UniProtAcc | O14737 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9141 | PDCD5 | CA_HPV_1 | Human | Cervix | CC | 1.89e-03 | -2.03e-01 | 0.0264 |
9141 | PDCD5 | CA_HPV_3 | Human | Cervix | CC | 1.95e-03 | 2.28e-01 | 0.0414 |
9141 | PDCD5 | CCI_1 | Human | Cervix | CC | 4.63e-04 | -4.84e-01 | 0.528 |
9141 | PDCD5 | CCI_2 | Human | Cervix | CC | 1.24e-02 | -4.58e-01 | 0.5249 |
9141 | PDCD5 | CCI_3 | Human | Cervix | CC | 2.78e-10 | -5.49e-01 | 0.516 |
9141 | PDCD5 | CCII_1 | Human | Cervix | CC | 3.28e-15 | -5.53e-01 | 0.3249 |
9141 | PDCD5 | sample3 | Human | Cervix | CC | 6.65e-03 | -6.67e-02 | 0.1387 |
9141 | PDCD5 | L1 | Human | Cervix | CC | 4.89e-07 | -1.37e-02 | 0.0802 |
9141 | PDCD5 | T3 | Human | Cervix | CC | 4.27e-03 | -9.57e-02 | 0.1389 |
9141 | PDCD5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.65e-03 | 1.95e-01 | -0.059 |
9141 | PDCD5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.50e-02 | 1.78e-01 | 0.096 |
9141 | PDCD5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-02 | 2.33e-01 | 0.0588 |
9141 | PDCD5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.23e-07 | 3.24e-01 | 0.3859 |
9141 | PDCD5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.87e-04 | 1.89e-01 | 0.3005 |
9141 | PDCD5 | AEH-subject1 | Human | Endometrium | AEH | 3.29e-09 | -3.15e-01 | -0.3059 |
9141 | PDCD5 | AEH-subject2 | Human | Endometrium | AEH | 8.86e-16 | -4.13e-01 | -0.2525 |
9141 | PDCD5 | AEH-subject3 | Human | Endometrium | AEH | 3.14e-10 | -2.84e-01 | -0.2576 |
9141 | PDCD5 | AEH-subject4 | Human | Endometrium | AEH | 1.91e-08 | -3.62e-01 | -0.2657 |
9141 | PDCD5 | AEH-subject5 | Human | Endometrium | AEH | 2.49e-03 | -2.69e-01 | -0.2953 |
9141 | PDCD5 | EEC-subject1 | Human | Endometrium | EEC | 2.64e-17 | -4.04e-01 | -0.2682 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003315710 | Endometrium | AEH | regulation of intracellular protein transport | 51/2100 | 229/18723 | 1.13e-06 | 3.75e-05 | 51 |
GO:003238810 | Endometrium | AEH | positive regulation of intracellular transport | 46/2100 | 202/18723 | 1.96e-06 | 5.93e-05 | 46 |
GO:005254716 | Endometrium | AEH | regulation of peptidase activity | 85/2100 | 461/18723 | 2.47e-06 | 7.11e-05 | 85 |
GO:00323869 | Endometrium | AEH | regulation of intracellular transport | 66/2100 | 337/18723 | 4.18e-06 | 1.10e-04 | 66 |
GO:00903168 | Endometrium | AEH | positive regulation of intracellular protein transport | 38/2100 | 160/18723 | 5.22e-06 | 1.33e-04 | 38 |
GO:007058510 | Endometrium | AEH | protein localization to mitochondrion | 32/2100 | 125/18723 | 5.38e-06 | 1.36e-04 | 32 |
GO:001095216 | Endometrium | AEH | positive regulation of peptidase activity | 44/2100 | 197/18723 | 5.53e-06 | 1.38e-04 | 44 |
GO:007265510 | Endometrium | AEH | establishment of protein localization to mitochondrion | 31/2100 | 120/18723 | 6.13e-06 | 1.50e-04 | 31 |
GO:00715596 | Endometrium | AEH | response to transforming growth factor beta | 53/2100 | 256/18723 | 7.01e-06 | 1.69e-04 | 53 |
GO:00715606 | Endometrium | AEH | cellular response to transforming growth factor beta stimulus | 51/2100 | 250/18723 | 1.59e-05 | 3.32e-04 | 51 |
GO:000662610 | Endometrium | AEH | protein targeting to mitochondrion | 26/2100 | 100/18723 | 2.96e-05 | 5.47e-04 | 26 |
GO:005254816 | Endometrium | AEH | regulation of endopeptidase activity | 76/2100 | 432/18723 | 4.42e-05 | 7.43e-04 | 76 |
GO:009015010 | Endometrium | AEH | establishment of protein localization to membrane | 51/2100 | 260/18723 | 4.74e-05 | 7.85e-04 | 51 |
GO:004328116 | Endometrium | AEH | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 43/2100 | 209/18723 | 5.77e-05 | 9.10e-04 | 43 |
GO:00070068 | Endometrium | AEH | mitochondrial membrane organization | 28/2100 | 116/18723 | 6.38e-05 | 9.94e-04 | 28 |
GO:19054779 | Endometrium | AEH | positive regulation of protein localization to membrane | 26/2100 | 106/18723 | 8.63e-05 | 1.27e-03 | 26 |
GO:200011616 | Endometrium | AEH | regulation of cysteine-type endopeptidase activity | 46/2100 | 235/18723 | 1.14e-04 | 1.62e-03 | 46 |
GO:001095015 | Endometrium | AEH | positive regulation of endopeptidase activity | 37/2100 | 179/18723 | 1.66e-04 | 2.16e-03 | 37 |
GO:00901518 | Endometrium | AEH | establishment of protein localization to mitochondrial membrane | 11/2100 | 30/18723 | 2.46e-04 | 2.93e-03 | 11 |
GO:000863710 | Endometrium | AEH | apoptotic mitochondrial changes | 25/2100 | 107/18723 | 2.65e-04 | 3.09e-03 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCD5 | SNV | Missense_Mutation | c.122A>G | p.Asn41Ser | p.N41S | O14737 | protein_coding | deleterious(0.02) | benign(0.174) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PDCD5 | SNV | Missense_Mutation | c.169A>G | p.Ser57Gly | p.S57G | O14737 | protein_coding | tolerated(0.07) | benign(0.134) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDCD5 | SNV | Missense_Mutation | c.213N>T | p.Glu71Asp | p.E71D | O14737 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDCD5 | SNV | Missense_Mutation | rs376281754 | c.70N>T | p.Pro24Ser | p.P24S | O14737 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD5 | SNV | Missense_Mutation | c.247C>A | p.Leu83Ile | p.L83I | O14737 | protein_coding | tolerated(0.93) | benign(0.009) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDCD5 | SNV | Missense_Mutation | rs201933073 | c.158N>A | p.Arg53Gln | p.R53Q | O14737 | protein_coding | deleterious(0.02) | possibly_damaging(0.761) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDCD5 | SNV | Missense_Mutation | c.253N>A | p.Glu85Lys | p.E85K | O14737 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
PDCD5 | SNV | Missense_Mutation | novel | c.331N>C | p.Phe111Leu | p.F111L | O14737 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDCD5 | SNV | Missense_Mutation | c.265G>C | p.Glu89Gln | p.E89Q | O14737 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-EJ-8470-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
PDCD5 | SNV | Missense_Mutation | c.258N>T | p.Lys86Asn | p.K86N | O14737 | protein_coding | deleterious(0) | benign(0.015) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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