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Gene: MLST8 |
Gene summary for MLST8 |
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Gene information | Species | Human | Gene symbol | MLST8 | Gene ID | 64223 |
Gene name | MTOR associated protein, LST8 homolog | |
Gene Alias | GBL | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q9BVC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64223 | MLST8 | LZE4T | Human | Esophagus | ESCC | 2.37e-06 | 1.68e-01 | 0.0811 |
64223 | MLST8 | LZE7T | Human | Esophagus | ESCC | 3.10e-07 | 4.08e-01 | 0.0667 |
64223 | MLST8 | LZE8T | Human | Esophagus | ESCC | 2.15e-14 | 2.34e-01 | 0.067 |
64223 | MLST8 | LZE20T | Human | Esophagus | ESCC | 1.16e-08 | 2.59e-01 | 0.0662 |
64223 | MLST8 | LZE22T | Human | Esophagus | ESCC | 4.40e-06 | 4.79e-01 | 0.068 |
64223 | MLST8 | LZE24T | Human | Esophagus | ESCC | 9.57e-15 | 3.78e-01 | 0.0596 |
64223 | MLST8 | LZE21T | Human | Esophagus | ESCC | 2.25e-05 | 2.39e-01 | 0.0655 |
64223 | MLST8 | LZE6T | Human | Esophagus | ESCC | 3.92e-03 | 1.52e-01 | 0.0845 |
64223 | MLST8 | P1T-E | Human | Esophagus | ESCC | 1.87e-17 | 5.73e-01 | 0.0875 |
64223 | MLST8 | P2T-E | Human | Esophagus | ESCC | 6.02e-67 | 1.20e+00 | 0.1177 |
64223 | MLST8 | P4T-E | Human | Esophagus | ESCC | 2.32e-51 | 1.16e+00 | 0.1323 |
64223 | MLST8 | P5T-E | Human | Esophagus | ESCC | 4.80e-25 | 4.72e-01 | 0.1327 |
64223 | MLST8 | P8T-E | Human | Esophagus | ESCC | 1.62e-28 | 5.13e-01 | 0.0889 |
64223 | MLST8 | P9T-E | Human | Esophagus | ESCC | 1.70e-16 | 2.90e-01 | 0.1131 |
64223 | MLST8 | P10T-E | Human | Esophagus | ESCC | 9.54e-33 | 5.09e-01 | 0.116 |
64223 | MLST8 | P11T-E | Human | Esophagus | ESCC | 7.46e-16 | 6.43e-01 | 0.1426 |
64223 | MLST8 | P12T-E | Human | Esophagus | ESCC | 5.38e-43 | 9.07e-01 | 0.1122 |
64223 | MLST8 | P15T-E | Human | Esophagus | ESCC | 7.32e-29 | 6.03e-01 | 0.1149 |
64223 | MLST8 | P16T-E | Human | Esophagus | ESCC | 3.26e-26 | 4.97e-01 | 0.1153 |
64223 | MLST8 | P17T-E | Human | Esophagus | ESCC | 9.88e-20 | 6.98e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008064110 | Skin | cSCC | regulation of actin polymerization or depolymerization | 71/4864 | 188/18723 | 2.38e-04 | 1.95e-03 | 71 |
GO:007190024 | Skin | cSCC | regulation of protein serine/threonine kinase activity | 123/4864 | 359/18723 | 2.70e-04 | 2.17e-03 | 123 |
GO:0030832110 | Skin | cSCC | regulation of actin filament length | 71/4864 | 189/18723 | 2.86e-04 | 2.28e-03 | 71 |
GO:003004124 | Skin | cSCC | actin filament polymerization | 68/4864 | 191/18723 | 1.98e-03 | 1.18e-02 | 68 |
GO:003083325 | Skin | cSCC | regulation of actin filament polymerization | 62/4864 | 172/18723 | 2.18e-03 | 1.29e-02 | 62 |
GO:003367425 | Skin | cSCC | positive regulation of kinase activity | 148/4864 | 467/18723 | 3.00e-03 | 1.66e-02 | 148 |
GO:004586025 | Skin | cSCC | positive regulation of protein kinase activity | 123/4864 | 386/18723 | 5.23e-03 | 2.64e-02 | 123 |
GO:003083820 | Skin | cSCC | positive regulation of actin filament polymerization | 37/4864 | 99/18723 | 8.14e-03 | 3.77e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa041362 | Esophagus | ESCC | Autophagy - other | 23/4205 | 32/8465 | 8.99e-03 | 2.14e-02 | 1.09e-02 | 23 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0413611 | Esophagus | ESCC | Autophagy - other | 23/4205 | 32/8465 | 8.99e-03 | 2.14e-02 | 1.09e-02 | 23 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0471414 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0471415 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MLST8 | SNV | Missense_Mutation | novel | c.706N>A | p.Ala236Thr | p.A236T | Q9BVC4 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MLST8 | insertion | Frame_Shift_Ins | novel | c.421_422insGCTGCATCTGTTACCGCCCTGAGGAGCAC | p.Ala141GlyfsTer27 | p.A141Gfs*27 | Q9BVC4 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
MLST8 | SNV | Missense_Mutation | c.161N>A | p.Arg54His | p.R54H | Q9BVC4 | protein_coding | deleterious(0) | possibly_damaging(0.772) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MLST8 | SNV | Missense_Mutation | c.258N>T | p.Lys86Asn | p.K86N | Q9BVC4 | protein_coding | tolerated(0.22) | possibly_damaging(0.772) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MLST8 | SNV | Missense_Mutation | novel | c.556N>A | p.Ala186Thr | p.A186T | Q9BVC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.625) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MLST8 | SNV | Missense_Mutation | novel | c.46N>A | p.Ala16Thr | p.A16T | Q9BVC4 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MLST8 | SNV | Missense_Mutation | c.258G>T | p.Lys86Asn | p.K86N | Q9BVC4 | protein_coding | tolerated(0.22) | possibly_damaging(0.772) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MLST8 | SNV | Missense_Mutation | novel | c.691G>A | p.Asp231Asn | p.D231N | Q9BVC4 | protein_coding | deleterious(0.02) | possibly_damaging(0.895) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MLST8 | SNV | Missense_Mutation | rs774913271 | c.661N>T | p.Arg221Cys | p.R221C | Q9BVC4 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MLST8 | SNV | Missense_Mutation | c.743G>T | p.Arg248Met | p.R248M | Q9BVC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64223 | MLST8 | KINASE | inhibitor | AZD8055 | AZD-8055 | |
64223 | MLST8 | KINASE | inhibitor | MLN0128 | SAPANISERTIB | |
64223 | MLST8 | KINASE | inhibitor | OSI-027 | OSI-027 |
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