![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MIF |
Gene summary for MIF |
![]() |
Gene information | Species | Human | Gene symbol | MIF | Gene ID | 4282 |
Gene name | macrophage migration inhibitory factor | |
Gene Alias | GIF | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I4AY87 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4282 | MIF | GSM4909281 | Human | Breast | IDC | 1.08e-77 | 6.83e-01 | 0.21 |
4282 | MIF | GSM4909285 | Human | Breast | IDC | 3.07e-22 | -3.93e-01 | 0.21 |
4282 | MIF | GSM4909286 | Human | Breast | IDC | 8.78e-17 | 4.21e-01 | 0.1081 |
4282 | MIF | GSM4909287 | Human | Breast | IDC | 1.14e-64 | 6.20e-01 | 0.2057 |
4282 | MIF | GSM4909288 | Human | Breast | IDC | 1.58e-02 | -2.18e-01 | 0.0988 |
4282 | MIF | GSM4909289 | Human | Breast | IDC | 8.47e-24 | 6.06e-01 | 0.1064 |
4282 | MIF | GSM4909290 | Human | Breast | IDC | 6.70e-79 | 7.59e-01 | 0.2096 |
4282 | MIF | GSM4909291 | Human | Breast | IDC | 8.23e-96 | 9.02e-01 | 0.1753 |
4282 | MIF | GSM4909292 | Human | Breast | IDC | 1.56e-10 | 4.37e-01 | 0.1236 |
4282 | MIF | GSM4909293 | Human | Breast | IDC | 8.84e-15 | -2.18e-01 | 0.1581 |
4282 | MIF | GSM4909294 | Human | Breast | IDC | 5.48e-12 | 1.47e-01 | 0.2022 |
4282 | MIF | GSM4909296 | Human | Breast | IDC | 2.28e-100 | 7.95e-01 | 0.1524 |
4282 | MIF | GSM4909297 | Human | Breast | IDC | 4.42e-22 | 9.80e-02 | 0.1517 |
4282 | MIF | GSM4909298 | Human | Breast | IDC | 1.16e-07 | 3.32e-01 | 0.1551 |
4282 | MIF | GSM4909300 | Human | Breast | IDC | 1.08e-14 | 4.42e-01 | 0.0334 |
4282 | MIF | GSM4909301 | Human | Breast | IDC | 1.40e-12 | 3.11e-01 | 0.1577 |
4282 | MIF | GSM4909302 | Human | Breast | IDC | 1.21e-18 | 2.14e-01 | 0.1545 |
4282 | MIF | GSM4909305 | Human | Breast | IDC | 4.92e-06 | 2.89e-01 | 0.0436 |
4282 | MIF | GSM4909306 | Human | Breast | IDC | 4.10e-81 | 7.13e-01 | 0.1564 |
4282 | MIF | GSM4909307 | Human | Breast | IDC | 6.23e-27 | 4.11e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007066511 | Breast | DCIS | positive regulation of leukocyte proliferation | 21/1390 | 150/18723 | 3.62e-03 | 2.94e-02 | 21 |
GO:003276021 | Breast | DCIS | positive regulation of tumor necrosis factor production | 16/1390 | 103/18723 | 3.75e-03 | 3.02e-02 | 16 |
GO:000756921 | Breast | DCIS | cell aging | 19/1390 | 132/18723 | 4.03e-03 | 3.20e-02 | 19 |
GO:00022742 | Breast | DCIS | myeloid leukocyte activation | 28/1390 | 223/18723 | 4.37e-03 | 3.41e-02 | 28 |
GO:00706616 | Breast | DCIS | leukocyte proliferation | 37/1390 | 318/18723 | 4.39e-03 | 3.41e-02 | 37 |
GO:000663322 | Breast | DCIS | fatty acid biosynthetic process | 22/1390 | 163/18723 | 4.62e-03 | 3.52e-02 | 22 |
GO:00903422 | Breast | DCIS | regulation of cell aging | 11/1390 | 61/18723 | 4.84e-03 | 3.67e-02 | 11 |
GO:00466515 | Breast | DCIS | lymphocyte proliferation | 34/1390 | 288/18723 | 4.91e-03 | 3.70e-02 | 34 |
GO:00421162 | Breast | DCIS | macrophage activation | 16/1390 | 106/18723 | 4.99e-03 | 3.72e-02 | 16 |
GO:00321021 | Breast | DCIS | negative regulation of response to external stimulus | 46/1390 | 420/18723 | 5.19e-03 | 3.81e-02 | 46 |
GO:190355711 | Breast | DCIS | positive regulation of tumor necrosis factor superfamily cytokine production | 16/1390 | 107/18723 | 5.48e-03 | 4.00e-02 | 16 |
GO:00329434 | Breast | DCIS | mononuclear cell proliferation | 34/1390 | 291/18723 | 5.75e-03 | 4.14e-02 | 34 |
GO:00481452 | Breast | DCIS | regulation of fibroblast proliferation | 13/1390 | 80/18723 | 5.80e-03 | 4.17e-02 | 13 |
GO:00482462 | Breast | DCIS | macrophage chemotaxis | 8/1390 | 38/18723 | 5.94e-03 | 4.25e-02 | 8 |
GO:00481442 | Breast | DCIS | fibroblast proliferation | 13/1390 | 81/18723 | 6.45e-03 | 4.58e-02 | 13 |
GO:19055172 | Breast | DCIS | macrophage migration | 10/1390 | 55/18723 | 6.66e-03 | 4.62e-02 | 10 |
GO:009719310 | Cervix | CC | intrinsic apoptotic signaling pathway | 85/2311 | 288/18723 | 4.56e-15 | 6.46e-12 | 85 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:200124210 | Cervix | CC | regulation of intrinsic apoptotic signaling pathway | 52/2311 | 164/18723 | 5.06e-11 | 1.01e-08 | 52 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | DCIS |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | DCIS |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | DCIS |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Healthy |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Healthy |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | IDC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | IDC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Precancer |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Precancer |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | CC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | CC |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | CC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | Healthy |
Page: 1 2 3 4 5 6 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIF | SNV | Missense_Mutation | novel | c.266N>C | p.Arg89Pro | p.R89P | P14174 | protein_coding | tolerated(0.21) | benign(0.219) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | novel | c.95N>A | p.Gly32Asp | p.G32D | P14174 | protein_coding | tolerated(0.06) | benign(0.136) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | c.52N>T | p.Gly18Trp | p.G18W | P14174 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ANTI-MIF MONOCLONAL ANTIBODY | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | COR100140 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PPD | 393437 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | Anti-MIF antibodies | 22238348 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | TCMDC-124484 | CHEMBL524449 | 21719283 | |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ISO-1 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PMA | 3305746 |
Page: 1 |