![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MIDN |
Gene summary for MIDN |
![]() |
Gene information | Species | Human | Gene symbol | MIDN | Gene ID | 90007 |
Gene name | midnolin | |
Gene Alias | Stx | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | Q504T8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90007 | MIDN | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.85e-19 | 1.02e+00 | -0.1808 |
90007 | MIDN | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-08 | 4.50e-01 | -0.0811 |
90007 | MIDN | HTA11_78_2000001011 | Human | Colorectum | AD | 2.05e-02 | 1.77e-01 | -0.1088 |
90007 | MIDN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.92e-18 | 4.83e-01 | -0.1954 |
90007 | MIDN | HTA11_411_2000001011 | Human | Colorectum | SER | 4.06e-04 | 9.65e-01 | -0.2602 |
90007 | MIDN | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.67e-08 | 1.06e+00 | -0.2196 |
90007 | MIDN | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-03 | 5.05e-01 | -0.1207 |
90007 | MIDN | HTA11_83_2000001011 | Human | Colorectum | SER | 1.86e-03 | 4.34e-01 | -0.1526 |
90007 | MIDN | HTA11_696_2000001011 | Human | Colorectum | AD | 1.27e-13 | 6.65e-01 | -0.1464 |
90007 | MIDN | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.64e-10 | 5.27e-01 | -0.059 |
90007 | MIDN | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.30e-03 | 5.03e-01 | -0.2061 |
90007 | MIDN | HTA11_866_3004761011 | Human | Colorectum | AD | 5.91e-03 | 2.01e-01 | 0.096 |
90007 | MIDN | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.91e-03 | 3.74e-01 | -0.0177 |
90007 | MIDN | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.85e-06 | 3.22e-01 | 0.0674 |
90007 | MIDN | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.90e-05 | 3.54e-01 | 0.294 |
90007 | MIDN | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.79e-02 | 1.85e-01 | 0.281 |
90007 | MIDN | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.55e-06 | 4.97e-01 | 0.3859 |
90007 | MIDN | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.56e-08 | 7.51e-01 | 0.2585 |
90007 | MIDN | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.26e-08 | 4.13e-01 | 0.3005 |
90007 | MIDN | A015-C-203 | Human | Colorectum | FAP | 4.78e-03 | -1.03e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005134812 | Liver | Cirrhotic | negative regulation of transferase activity | 93/4634 | 268/18723 | 1.55e-04 | 1.47e-03 | 93 |
GO:004426211 | Liver | Cirrhotic | cellular carbohydrate metabolic process | 97/4634 | 283/18723 | 1.89e-04 | 1.76e-03 | 97 |
GO:00109061 | Liver | Cirrhotic | regulation of glucose metabolic process | 47/4634 | 119/18723 | 2.61e-04 | 2.33e-03 | 47 |
GO:00106751 | Liver | Cirrhotic | regulation of cellular carbohydrate metabolic process | 54/4634 | 146/18723 | 6.53e-04 | 4.96e-03 | 54 |
GO:19049502 | Liver | Cirrhotic | negative regulation of establishment of protein localization | 49/4634 | 131/18723 | 8.50e-04 | 6.15e-03 | 49 |
GO:0051224 | Liver | Cirrhotic | negative regulation of protein transport | 47/4634 | 127/18723 | 1.39e-03 | 9.27e-03 | 47 |
GO:003367312 | Liver | Cirrhotic | negative regulation of kinase activity | 78/4634 | 237/18723 | 2.73e-03 | 1.59e-02 | 78 |
GO:00510514 | Liver | Cirrhotic | negative regulation of transport | 141/4634 | 470/18723 | 5.06e-03 | 2.62e-02 | 141 |
GO:00459121 | Liver | Cirrhotic | negative regulation of carbohydrate metabolic process | 20/4634 | 48/18723 | 7.37e-03 | 3.52e-02 | 20 |
GO:00106771 | Liver | Cirrhotic | negative regulation of cellular carbohydrate metabolic process | 18/4634 | 42/18723 | 7.64e-03 | 3.61e-02 | 18 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
GO:004593622 | Liver | HCC | negative regulation of phosphate metabolic process | 258/7958 | 441/18723 | 6.00e-12 | 2.60e-10 | 258 |
GO:004232622 | Liver | HCC | negative regulation of phosphorylation | 227/7958 | 385/18723 | 3.98e-11 | 1.52e-09 | 227 |
GO:000600621 | Liver | HCC | glucose metabolic process | 128/7958 | 196/18723 | 8.60e-11 | 3.06e-09 | 128 |
GO:005134822 | Liver | HCC | negative regulation of transferase activity | 166/7958 | 268/18723 | 8.97e-11 | 3.18e-09 | 166 |
GO:003367322 | Liver | HCC | negative regulation of kinase activity | 144/7958 | 237/18723 | 9.76e-09 | 2.45e-07 | 144 |
GO:006201222 | Liver | HCC | regulation of small molecule metabolic process | 190/7958 | 334/18723 | 6.77e-08 | 1.40e-06 | 190 |
GO:000610921 | Liver | HCC | regulation of carbohydrate metabolic process | 109/7958 | 178/18723 | 3.36e-07 | 5.78e-06 | 109 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIDN | SNV | Missense_Mutation | novel | c.587N>T | p.Ser196Phe | p.S196F | Q504T8 | protein_coding | deleterious(0.01) | benign(0) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
MIDN | SNV | Missense_Mutation | c.878N>T | p.Gln293Leu | p.Q293L | Q504T8 | protein_coding | deleterious(0) | benign(0.164) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
MIDN | SNV | Missense_Mutation | rs746153442 | c.946G>A | p.Ala316Thr | p.A316T | Q504T8 | protein_coding | deleterious(0) | benign(0.187) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MIDN | SNV | Missense_Mutation | rs766876307 | c.826G>A | p.Ala276Thr | p.A276T | Q504T8 | protein_coding | deleterious(0.02) | possibly_damaging(0.889) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
MIDN | SNV | Missense_Mutation | novel | c.282C>A | p.Ser94Arg | p.S94R | Q504T8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4682-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | camptosar | PD |
MIDN | SNV | Missense_Mutation | rs753884875 | c.992N>A | p.Arg331His | p.R331H | Q504T8 | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MIDN | SNV | Missense_Mutation | rs764769740 | c.1339N>A | p.Asp447Asn | p.D447N | Q504T8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MIDN | SNV | Missense_Mutation | c.162N>C | p.Glu54Asp | p.E54D | Q504T8 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MIDN | SNV | Missense_Mutation | rs138120774 | c.802G>A | p.Val268Ile | p.V268I | Q504T8 | protein_coding | tolerated(0.43) | benign(0.099) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
MIDN | deletion | Frame_Shift_Del | c.1297delN | p.Gly434AlafsTer91 | p.G434Afs*91 | Q504T8 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |