Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LAMB2

Gene summary for LAMB2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LAMB2

Gene ID

3913

Gene namelaminin subunit beta 2
Gene AliasLAMS
Cytomap3p21.31
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

A0A024R319


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3913LAMB2S43HumanLiverCirrhotic5.59e-053.31e-01-0.0187
3913LAMB2HCC1_MengHumanLiverHCC2.18e-443.50e-020.0246
3913LAMB2HCC2_MengHumanLiverHCC6.46e-14-1.60e-020.0107
3913LAMB2cirrhotic2HumanLiverCirrhotic1.74e-132.56e-010.0201
3913LAMB2cirrhotic3HumanLiverCirrhotic1.16e-092.49e-010.0215
3913LAMB2HCC1HumanLiverHCC5.52e-043.75e+000.5336
3913LAMB2HCC2HumanLiverHCC1.51e-083.52e+000.5341
3913LAMB2Pt13.bHumanLiverHCC4.34e-051.14e-010.0251
3913LAMB2Pt14.bHumanLiverHCC2.72e-032.76e-010.018
3913LAMB2S014HumanLiverHCC1.47e-064.29e-010.2254
3913LAMB2S015HumanLiverHCC2.63e-086.80e-010.2375
3913LAMB2S016HumanLiverHCC1.58e-074.37e-010.2243
3913LAMB2S027HumanLiverHCC2.99e-108.22e-010.2446
3913LAMB2S028HumanLiverHCC2.00e-188.76e-010.2503
3913LAMB2S029HumanLiverHCC7.15e-249.42e-010.2581
3913LAMB2C21HumanOral cavityOSCC2.79e-039.93e-020.2678
3913LAMB2C30HumanOral cavityOSCC3.19e-054.85e-010.3055
3913LAMB2C46HumanOral cavityOSCC1.74e-041.54e-010.1673
3913LAMB2C08HumanOral cavityOSCC1.75e-027.90e-020.1919
3913LAMB2C09HumanOral cavityOSCC1.32e-064.06e-010.1431
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:007200113ProstateTumorrenal system development75/3246302/187235.74e-044.13e-0375
GO:004858814ProstateTumordevelopmental cell growth60/3246234/187238.41e-045.66e-0360
GO:007171111ProstateTumorbasement membrane organization13/324631/187231.14e-037.27e-0313
GO:004206312ProstateTumorgliogenesis73/3246301/187231.35e-038.46e-0373
GO:006056014ProstateTumordevelopmental growth involved in morphogenesis59/3246234/187231.43e-038.84e-0359
GO:007200913ProstateTumornephron epithelium development31/3246109/187232.70e-031.48e-0231
GO:000165612ProstateTumormetanephros development25/324685/187234.12e-032.08e-0225
GO:00100014ProstateTumorglial cell differentiation55/3246225/187234.13e-032.08e-0255
GO:00140371ProstateTumorSchwann cell differentiation14/324640/187235.52e-032.61e-0214
GO:007200613ProstateTumornephron development37/3246142/187235.73e-032.67e-0237
GO:004867514ProstateTumoraxon extension32/3246120/187236.77e-033.09e-0232
GO:199013814ProstateTumorneuron projection extension43/3246172/187236.83e-033.10e-0243
GO:00016541ProstateTumoreye development82/3246371/187231.02e-024.27e-0282
GO:003585012ProstateTumorepithelial cell differentiation involved in kidney development15/324647/187231.07e-024.45e-0215
GO:0016049112ThyroidPTCcell growth225/5968482/187234.75e-122.07e-10225
GO:0031589111ThyroidPTCcell-substrate adhesion169/5968363/187232.73e-097.57e-08169
GO:006156419ThyroidPTCaxon development199/5968467/187235.27e-078.53e-06199
GO:000182215ThyroidPTCkidney development133/5968293/187237.57e-071.18e-05133
GO:000165517ThyroidPTCurogenital system development149/5968338/187231.41e-062.01e-05149
GO:007200114ThyroidPTCrenal system development135/5968302/187231.76e-062.43e-05135
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0451021LiverCirrhoticFocal adhesion93/2530203/84659.27e-071.10e-056.80e-0693
hsa05165LiverCirrhoticHuman papillomavirus infection124/2530331/84651.55e-037.83e-034.83e-03124
hsa0514512LiverCirrhoticToxoplasmosis47/2530112/84654.16e-031.63e-021.00e-0247
hsa0451031LiverCirrhoticFocal adhesion93/2530203/84659.27e-071.10e-056.80e-0693
hsa051651LiverCirrhoticHuman papillomavirus infection124/2530331/84651.55e-037.83e-034.83e-03124
hsa0514513LiverCirrhoticToxoplasmosis47/2530112/84654.16e-031.63e-021.00e-0247
hsa0451041LiverHCCFocal adhesion125/4020203/84653.12e-051.88e-041.04e-04125
hsa051652LiverHCCHuman papillomavirus infection188/4020331/84653.34e-041.49e-038.29e-04188
hsa0514521LiverHCCToxoplasmosis70/4020112/84659.25e-043.52e-031.96e-0370
hsa052224LiverHCCSmall cell lung cancer57/402092/84653.54e-031.12e-026.22e-0357
hsa0451051LiverHCCFocal adhesion125/4020203/84653.12e-051.88e-041.04e-04125
hsa051653LiverHCCHuman papillomavirus infection188/4020331/84653.34e-041.49e-038.29e-04188
hsa0514531LiverHCCToxoplasmosis70/4020112/84659.25e-043.52e-031.96e-0370
hsa0522211LiverHCCSmall cell lung cancer57/402092/84653.54e-031.12e-026.22e-0357
hsa051659Oral cavityOSCCHuman papillomavirus infection200/3704331/84653.83e-104.93e-092.51e-09200
hsa0451019Oral cavityOSCCFocal adhesion128/3704203/84651.71e-081.63e-078.31e-08128
hsa052228Oral cavityOSCCSmall cell lung cancer66/370492/84654.43e-083.38e-071.72e-0766
hsa0514520Oral cavityOSCCToxoplasmosis75/3704112/84655.28e-073.16e-061.61e-0675
hsa041516Oral cavityOSCCPI3K-Akt signaling pathway185/3704354/84656.26e-041.86e-039.49e-04185
hsa051468Oral cavityOSCCAmoebiasis59/3704102/84652.78e-037.17e-033.65e-0359
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
LAMB2ITGA1_ITGB1LAMB2_ITGA1_ITGB1LAMININBreastADJ
LAMB2ITGA2_ITGB1LAMB2_ITGA2_ITGB1LAMININBreastADJ
LAMB2CD44LAMB2_CD44LAMININBreastADJ
LAMB2ITGA1_ITGB1LAMB2_ITGA1_ITGB1LAMININBreastDCIS
LAMB2ITGA2_ITGB1LAMB2_ITGA2_ITGB1LAMININBreastDCIS
LAMB2ITGA6_ITGB1LAMB2_ITGA6_ITGB1LAMININBreastDCIS
LAMB2ITGA7_ITGB1LAMB2_ITGA7_ITGB1LAMININBreastDCIS
LAMB2ITGA6_ITGB4LAMB2_ITGA6_ITGB4LAMININBreastDCIS
LAMB2CD44LAMB2_CD44LAMININBreastDCIS
LAMB2DAG1LAMB2_DAG1LAMININBreastDCIS
LAMB2ITGA1_ITGB1LAMB2_ITGA1_ITGB1LAMININBreastHealthy
LAMB2ITGA2_ITGB1LAMB2_ITGA2_ITGB1LAMININBreastHealthy
LAMB2ITGA6_ITGB1LAMB2_ITGA6_ITGB1LAMININBreastHealthy
LAMB2ITGA7_ITGB1LAMB2_ITGA7_ITGB1LAMININBreastHealthy
LAMB2ITGAV_ITGB8LAMB2_ITGAV_ITGB8LAMININBreastHealthy
LAMB2CD44LAMB2_CD44LAMININBreastHealthy
LAMB2ITGA1_ITGB1LAMB2_ITGA1_ITGB1LAMININBreastIDC
LAMB2ITGA6_ITGB1LAMB2_ITGA6_ITGB1LAMININBreastIDC
LAMB2CD44LAMB2_CD44LAMININBreastIDC
LAMB2ITGA1_ITGB1LAMB2_ITGA1_ITGB1LAMININBreastPrecancer
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
LAMB2SNVMissense_Mutationc.5393N>Tp.Gln1798Leup.Q1798LP55268protein_codingdeleterious(0)probably_damaging(0.991)TCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
LAMB2SNVMissense_Mutationrs762984990c.3442N>Tp.Arg1148Cysp.R1148CP55268protein_codingdeleterious(0.01)possibly_damaging(0.524)TCGA-AC-A3W6-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
LAMB2SNVMissense_Mutationc.1000C>Tp.Arg334Cysp.R334CP55268protein_codingdeleterious(0)possibly_damaging(0.837)TCGA-D8-A1X5-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapytamoxiphenSD
LAMB2SNVMissense_Mutationc.931N>Gp.Ile311Valp.I311VP55268protein_codingtolerated(1)benign(0)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
LAMB2SNVMissense_Mutationrs777003946c.1264N>Tp.Arg422Cysp.R422CP55268protein_codingdeleterious(0.03)possibly_damaging(0.576)TCGA-E2-A14Q-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
LAMB2SNVMissense_Mutationc.4868N>Ap.Gly1623Aspp.G1623DP55268protein_codingtolerated(0.44)possibly_damaging(0.738)TCGA-E2-A14Y-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinSD
LAMB2SNVMissense_Mutationc.2260N>Ap.Leu754Metp.L754MP55268protein_codingtolerated(0.46)benign(0.09)TCGA-E9-A1R4-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilSD
LAMB2SNVMissense_Mutationc.3107N>Gp.His1036Argp.H1036RP55268protein_codingtolerated(1)benign(0)TCGA-EW-A1IZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
LAMB2SNVMissense_Mutationc.311N>Gp.His104Argp.H104RP55268protein_codingtolerated(0.37)benign(0.02)TCGA-GM-A2DD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilCR
LAMB2insertionNonsense_Mutationnovelc.5165_5166insGTAGTATGTTTGAATCTTCTGATATCTCCTp.Gln1722_Gly1723insTerp.Q1722_G1723ins*P55268protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
3913LAMB2DRUGGABLE GENOMECHEMBL2095222OCRIPLASMIN
3913LAMB2DRUGGABLE GENOMECHEMBL2095222OCRIPLASMIN
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