Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/KIF3B_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/KIF3B_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIF3B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIF3B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KIF3B_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/KIF3B_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIF3B_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00009109 | Prostate | BPH | cytokinesis | 55/3107 | 173/18723 | 5.81e-07 | 1.15e-05 | 55 |
GO:00516508 | Prostate | BPH | establishment of vesicle localization | 49/3107 | 161/18723 | 9.12e-06 | 1.28e-04 | 49 |
GO:00109705 | Prostate | BPH | transport along microtubule | 47/3107 | 155/18723 | 1.53e-05 | 1.95e-04 | 47 |
GO:00457878 | Prostate | BPH | positive regulation of cell cycle | 81/3107 | 313/18723 | 1.76e-05 | 2.18e-04 | 81 |
GO:00516488 | Prostate | BPH | vesicle localization | 51/3107 | 177/18723 | 3.20e-05 | 3.61e-04 | 51 |
GO:00315033 | Prostate | BPH | protein-containing complex localization | 59/3107 | 220/18723 | 8.01e-05 | 7.66e-04 | 59 |
GO:19028505 | Prostate | BPH | microtubule cytoskeleton organization involved in mitosis | 43/3107 | 147/18723 | 8.78e-05 | 8.27e-04 | 43 |
GO:00070525 | Prostate | BPH | mitotic spindle organization | 36/3107 | 120/18723 | 1.83e-04 | 1.54e-03 | 36 |
GO:00080888 | Prostate | BPH | axo-dendritic transport | 25/3107 | 75/18723 | 2.94e-04 | 2.28e-03 | 25 |
GO:00903075 | Prostate | BPH | mitotic spindle assembly | 22/3107 | 65/18723 | 5.23e-04 | 3.68e-03 | 22 |
GO:00070516 | Prostate | BPH | spindle organization | 48/3107 | 184/18723 | 6.91e-04 | 4.60e-03 | 48 |
GO:00991112 | Prostate | BPH | microtubule-based transport | 49/3107 | 190/18723 | 8.05e-04 | 5.27e-03 | 49 |
GO:00723844 | Prostate | BPH | organelle transport along microtubule | 26/3107 | 85/18723 | 9.92e-04 | 6.24e-03 | 26 |
GO:00900687 | Prostate | BPH | positive regulation of cell cycle process | 58/3107 | 236/18723 | 1.03e-03 | 6.46e-03 | 58 |
GO:00995183 | Prostate | BPH | vesicle cytoskeletal trafficking | 23/3107 | 73/18723 | 1.22e-03 | 7.41e-03 | 23 |
GO:01400144 | Prostate | BPH | mitotic nuclear division | 67/3107 | 287/18723 | 1.87e-03 | 1.07e-02 | 67 |
GO:00989302 | Prostate | BPH | axonal transport | 20/3107 | 64/18723 | 2.75e-03 | 1.46e-02 | 20 |
GO:00512254 | Prostate | BPH | spindle assembly | 31/3107 | 117/18723 | 4.39e-03 | 2.16e-02 | 31 |
GO:00324651 | Prostate | BPH | regulation of cytokinesis | 25/3107 | 92/18723 | 7.02e-03 | 3.14e-02 | 25 |
GO:00513023 | Prostate | BPH | regulation of cell division | 42/3107 | 177/18723 | 8.93e-03 | 3.82e-02 | 42 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF3B | SNV | Missense_Mutation | | c.1484N>T | p.Lys495Ile | p.K495I | O15066 | protein_coding | deleterious(0) | possibly_damaging(0.514) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIF3B | SNV | Missense_Mutation | | c.1579T>C | p.Tyr527His | p.Y527H | O15066 | protein_coding | tolerated(0.07) | probably_damaging(0.947) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
KIF3B | SNV | Missense_Mutation | novel | c.122N>G | p.Val41Gly | p.V41G | O15066 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KIF3B | SNV | Missense_Mutation | novel | c.1367A>G | p.Glu456Gly | p.E456G | O15066 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIF3B | insertion | Nonsense_Mutation | novel | c.2191_2192insATCATT | p.Gly731delinsAspHisTer | p.G731delinsDH* | O15066 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
KIF3B | insertion | In_Frame_Ins | novel | c.2192_2193insGAAACTACATCCTAT | p.Gly731_Thr732insLysLeuHisProIle | p.G731_T732insKLHPI | O15066 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
KIF3B | SNV | Missense_Mutation | novel | c.952N>A | p.Gly318Arg | p.G318R | O15066 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KIF3B | SNV | Missense_Mutation | | c.646N>G | p.His216Asp | p.H216D | O15066 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
KIF3B | SNV | Missense_Mutation | novel | c.1231N>T | p.Asp411Tyr | p.D411Y | O15066 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KIF3B | SNV | Missense_Mutation | novel | c.2186N>T | p.Ser729Phe | p.S729F | O15066 | protein_coding | deleterious(0.04) | benign(0.133) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |